Protein Alignment ltl and CG4950

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_648855.2
• Gene: CG4950 / 39783
• FlyBaseID: FBgn0036587
• Length: 574
• Species: Drosophila melanogaster
• Alignment Length: 560
• Identity: 125/560 - (22%)
• Similarity: 212/560 - (37%)
• Gaps: 144/560 - (25%)

  Fly    22 ISPCTCETGKAWNHVELSCEKLESFNAVVDSLANKLNADTN------IDLKITHSQLDDLEMRSF 80
            ||.|....|    .:.|.|::.:|...:          |.|      ....:||||
  Fly    18 ISSCDGSGG----DIPLRCDEYDSMGYM----------DVNEAFCTVTGFTVTHSQ--------- 59

  Fly    81 TDMNFNLYKLRMQWNSLKSLPEVPFRGLSNVTYLSIGDNDLDEIPKHALSHMPSLLTLDIGRCKI 145
                 |:.        :|::|..     :.|.::...::.|..:|.|.....|.|.|||:....|
  Fly    60 -----NVV--------IKNIPPG-----NMVKFMKFYESTLLYMPFHLFETFPYLKTLDVSNTNI 106

  Fly   146 RAVQQEDFRGIQRVTNLILVSNIITRLDRGSF--PKSLLILHLGRNQLESLN-GSLHDLHNLESL 207
            ..:.:..|.....:|.|.|..|.:|.:....|  ...|:.|.|..|::.||: .:...||.:..:
  Fly   107 LELTRNAFSAASNLTYLNLAYNNLTSIQTSVFIGANVLMRLDLSYNEISSLSVNAFCGLHTISQI 171

  Fly   208 FINANNITSLDDELPDGGQLRLLMAHNNRLERLPANMAGMHSLETVHIHCNQLRSFD-RVLRNAV 271
            ::..|.:..|.::         :...|..||:             |....|.|.|.. .|.||..
  Fly   172 YLTGNLLKELHND---------IFKDNEYLEK-------------VSFEGNLLTSIQPEVFRNMR 214

  Fly   272 NLSEVMADNNELEYLAQDEFASCSKVETLQMGCNHIKS-------------LNSSLLPILKLKNA 323
            .:.||...||.|.::..|.||..:.:|.|.:..|.:|:             |:::.|..|.:...
  Fly   215 RIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELKNFQLTEKNIVHQLHLDNNYLTNLTINAT 279

  Fly   324 NF---SFNDIEEFSMAELHGLRSLKTLQLSSNRIQRLLPDPRGVQELM-LVNLDLDNNRIDSLN- 383
            .|   |.|.|.|..   ||....::||.||:|::..:    ..:..:. ::.||:.:|.|..||
  Fly   280 RFVRASHNQISELF---LHQSLHIETLDLSANKLSSI----SNITNITHMLYLDVSDNPIGPLNI 337

  Fly   384 GALAGLGNLRILNLAGNRLEHLQVGDFDGMIRLDILDLTGNQLAELKPLEMTL--LPSLKILKVA 446
            ...:.|..||.|||.|..:..|:.|.|.....|:.|||:.|.|..|. |:|.:  |.:||...:.
  Fly   338 STFSQLKRLRGLNLRGTGIRELKFGMFSKQKYLEELDLSFNNLTILN-LDMFVPYLTNLKKFLID 401

  Fly   447 YNNITKLEQD---FKGLPVLCQANLTNNQIS-----------TISSELVTNTRCKNHNVPGKLEI 497
            .|.:|:|:.:   .:..|.|.:..::.|:.:           ::...:|.|.         :.:.
  Fly   402 GNGLTELQGNRTFSEAFPQLQKLGVSRNRFNCSYLHHLLIPPSLPESVVLNI---------EPDT 457

  Fly   498 HLDDNPIMCDVGLNELCRLMAVQEARIRGRSQCFENDQEV 537
            :||:.|.:.||                    .|....|||
  Fly   458 NLDETPHIRDV--------------------SCISQSQEV 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	105/448 (23%)
		leucine-rich repeat	65..86	CDD:275380	4/20 (20%)
		leucine-rich repeat	87..110	CDD:275380	2/22 (9%)
		leucine-rich repeat	111..134	CDD:275380	4/22 (18%)
		leucine-rich repeat	135..158	CDD:275380	6/22 (27%)
		leucine-rich repeat	159..180	CDD:275380	6/22 (27%)
		leucine-rich repeat	181..203	CDD:275380	7/22 (32%)
		leucine-rich repeat	204..226	CDD:275380	2/21 (10%)
		leucine-rich repeat	227..249	CDD:275380	3/21 (14%)
		leucine-rich repeat	250..272	CDD:275380	7/22 (32%)
		leucine-rich repeat	273..296	CDD:275380	8/22 (36%)
		leucine-rich repeat	297..315	CDD:275380	5/30 (17%)
		leucine-rich repeat	320..335	CDD:275378	5/17 (29%)
		leucine-rich repeat	344..366	CDD:275380	5/21 (24%)
		leucine-rich repeat	367..391	CDD:275380	7/25 (28%)
		leucine-rich repeat	392..415	CDD:275380	9/22 (41%)
		leucine-rich repeat	416..439	CDD:275380	10/24 (42%)
		leucine-rich repeat	440..462	CDD:275380	5/24 (21%)
		leucine-rich repeat	463..483	CDD:275380	3/30 (10%)
CG4950	NP_648855.2	LRR	96..411	CDD:443914	90/344 (26%)
		leucine-rich repeat	96..119	CDD:275380	6/22 (27%)
		leucine-rich repeat	120..143	CDD:275380	6/22 (27%)
		leucine-rich repeat	144..167	CDD:275380	7/22 (32%)
		leucine-rich repeat	168..191	CDD:275380	3/31 (10%)
		leucine-rich repeat	192..215	CDD:275380	9/35 (26%)
		leucine-rich repeat	216..239	CDD:275380	8/22 (36%)
		leucine-rich repeat	240..299	CDD:275380	14/61 (23%)
		leucine-rich repeat	300..321	CDD:275380	5/24 (21%)
		leucine-rich repeat	322..345	CDD:275380	7/22 (32%)
		leucine-rich repeat	346..365	CDD:275380	8/18 (44%)
		leucine-rich repeat	370..394	CDD:275380	10/24 (42%)
		leucine-rich repeat	395..420	CDD:275380	5/24 (21%)