DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ltl and rdo

DIOPT Version :9

Sequence 1:	NP_001261524.1	Gene:	ltl / 38845	FlyBaseID:	FBgn0268063	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster

Alignment Length:	827	Identity:	177/827 - (21%)
Similarity:	296/827 - (35%)	Gaps:	212/827 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 CTCETGKAWNHVELSCEKLESFNAV-----VDSLANKLNADTNIDLKITHSQLDDL----EMRSF 80
            |.|           |.:.|:.:.|:     ::||.:....|.::.:.|.....:.:    .:|.|
  Fly    28 CQC-----------SMDDLDRYQAICTKGGLNSLLSPNELDVDVKVIIIRGPRNSITIGPALRQF 81

  Fly    81 TDMNFNLYKLRMQWNSLKSLPEVPFRGLSNVTYLSIGDNDLDEIPKHALSHMPSLLTLDIGRCKI 145
            ..:..    ||:..::|.::....|.||..:..|.:..|::..|.::......:||.||:.:.|:
  Fly    82 MKLEI----LRITDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNFRGQDNLLELDLSKNKV 142

  Fly   146 RAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPKSLLILHLGRNQLESLNGS-LHDLHNLESLFI 209
            ..:....||.:..:..|.|..|.|..|.:.:|      ..|.|.:...|:|: |.||.
  Fly   143 LRMASSTFRHLTDLRRLNLADNSIVELVQRNF------FMLSRLKYLDLSGNPLQDLQ------- 194

  Fly   210 NANNITSLDDELPDGGQLRLLMAHNNRLERLPANMAG-MHSLETVHIHCNQLRSFDR-VLRNAVN 272
                    .|...|..:|::|...|.:|:::...|.. :..|..:.:..|:.:..|: ..|:...
  Fly   195 --------PDVFRDVPELKVLKCRNCQLKKINPQMYNLLPLLSELDLGRNEFKFLDKDEFRDVKR 251

  Fly   273 LSEVMADNNELEYLAQDEFASCSKVETLQMGCNHI-KSLNSSLLPILKLKNANFSFNDIEEFSMA 336
            |::|:.|.|:|..:....|.....:..|.:..|.: |..|.|.|.:..|...:.|:|.:......
  Fly   252 LTKVLLDGNQLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQ 316

  Fly   337 ELHGLRSLKTLQLSSNRIQRLLPDPRGVQE--------LMLVNLDLDNNRIDSLNG-ALAGLG-- 390
            .:..|.:|.||.:|.|    :|.|.|.::|        ..|....|....|..|.. |:|.:|
  Fly   317 SIRSLSNLLTLNISGN----VLMDLREMRETFEPLIYYFFLTCSKLFFQLIPQLTHLAIADMGTM 377

  Fly   391 ---------NLRILNLAGNRLEHLQVGDFDGMIRLDILDLTGNQLAELKPLEMTLLPSLKILKVA 446
                     .||.||::||.|.:..:...|....|:.|||:.|||..:.  |.|:|....|..|.
  Fly   378 PVGLLHPFKQLRYLNISGNSLNNTALEVIDPCRELEFLDLSRNQLHGIS--EDTVLRIQGIRNVR 440

  Fly   447 YNN----------------ITKLEQDFKGLPV------LCQANLTNNQIS------TISSELVTN 483
            .:|                :.:|:..:...|:      |..|.:.|..|:      |..::...|
  Fly   441 LDNNPLICDECHMGKLINVVRQLQWKWDTYPICFLPKSLRGAEINNLDINGLHTCLTFITDEEQN 505

  Fly   484 TRCKNHNVPGKLEIHLDDNPIMCDVGLNELCRLMAV-------------------------QEAR 523
            ....::|.   ||          ..|||.|..|..:                         :|..
  Fly   506 AASTSYNF---LE----------HGGLNTLAILGGIIFVLIAVIILSLVACFSKNRARYYTREDH 557

  Fly   524 IRG-RSQCFENDQEVCTVLPMLYNVNLPIMVTNLKLTGREVPKPMVRVIVPSLIKANNELLPPLI 587
            :.| .|:|.|.:.| .|.:..|.|.:.|...|.|.|.        .....|:..|.|.:.|....
  Fly   558 LNGSESKCLEKNLE-ATTITTLGNGSSPTTTTTLTLA--------TSPAAPNGPKTNGQGLSLSP 613

  Fly   588 ATLGNPVL-ISTDL---VN---PV---------ISPLPPPLLLATTTPPPPLPLPVESEVEKNES 636
            |....||. ||.|.   :|   ||         :.|.|||       ||...|.|....:..:.|
  Fly   614 ANGSTPVHGISDDKGKEINFTFPVDDRVCTIDELMPSPPP-------PPQQHPHPNMGSLMYSVS 671

  Fly   637 TTANPVPTNYTQETTTTTSTTTTTTTTETSSQVAPIEIITTTAPTTTTTSTTTPKPNETLPVIVE 701
            .:.|         :.||.:......|           :|...||:.::..|.||.|.|.:.|:
  Fly   672 HSPN---------SATTLAAVAAAAT-----------VIPPGAPSHSSMPTPTPTPAEAVVVV-- 714

  Fly   702 LQDPNPPDTTVNQTALVPPVVLDPLQQDLERERERERERELERDLDH 748
                            :||..|.|.|...:.:......||:::.|.|
  Fly   715 ----------------LPPPPLPPQQHHHQMDGSLASLREVQQQLVH 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380	3/24 (13%)
		LRR_8	86..145	CDD:290566	13/58 (22%)
		leucine-rich repeat	87..110	CDD:275380	6/22 (27%)
		leucine-rich repeat	111..134	CDD:275380	3/22 (14%)
		leucine-rich repeat	135..158	CDD:275380	7/22 (32%)
		LRR_8	158..214	CDD:290566	13/56 (23%)
		leucine-rich repeat	159..180	CDD:275380	6/20 (30%)
		leucine-rich repeat	181..203	CDD:275380	7/22 (32%)
		leucine-rich repeat	204..226	CDD:275380	2/21 (10%)
		LRR_RI	226..451	CDD:238064	62/263 (24%)
		leucine-rich repeat	227..249	CDD:275380	5/22 (23%)
		leucine-rich repeat	250..272	CDD:275380	4/22 (18%)
		leucine-rich repeat	273..296	CDD:275380	6/22 (27%)
		leucine-rich repeat	297..315	CDD:275380	5/18 (28%)
		LRR_8	319..402	CDD:290566	26/102 (25%)
		leucine-rich repeat	320..335	CDD:275378	3/14 (21%)
		leucine-rich repeat	344..366	CDD:275380	8/21 (38%)
		leucine-rich repeat	367..391	CDD:275380	7/35 (20%)
		LRR_8	369..426	CDD:290566	20/68 (29%)
		leucine-rich repeat	392..415	CDD:275380	8/22 (36%)
		leucine-rich repeat	416..439	CDD:275380	10/22 (45%)
		LRR_8	438..>479	CDD:290566	10/68 (15%)
		leucine-rich repeat	440..462	CDD:275380	4/37 (11%)
		leucine-rich repeat	463..483	CDD:275380	5/25 (20%)
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	6/26 (23%)
		leucine-rich repeat	108..131	CDD:275380	3/22 (14%)
		LRR_8	131..190	CDD:290566	17/64 (27%)
		leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		LRR_RI	151..422	CDD:238064	70/295 (24%)
		leucine-rich repeat	156..179	CDD:275380	7/28 (25%)
		LRR_8	178..262	CDD:290566	21/98 (21%)
		leucine-rich repeat	180..203	CDD:275380	7/37 (19%)
		leucine-rich repeat	204..251	CDD:275380	9/46 (20%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
		LRR_8	274..334	CDD:290566	15/63 (24%)
		leucine-rich repeat	276..299	CDD:275380	6/22 (27%)
		LRR_4	298..342	CDD:289563	12/47 (26%)
		leucine-rich repeat	300..323	CDD:275380	4/22 (18%)
		leucine-rich repeat	388..411	CDD:275380	8/22 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453828
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930