DRSC/TRiP Functional Genomics Resources

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Protein Alignment ltl and IGFALS

DIOPT Version :9

Sequence 1:NP_001261524.1 Gene:ltl / 38845 FlyBaseID:FBgn0268063 Length:817 Species:Drosophila melanogaster
Sequence 2:NP_001139478.1 Gene:IGFALS / 3483 HGNCID:5468 Length:643 Species:Homo sapiens


Alignment Length:464 Identity:130/464 - (28%)
Similarity:204/464 - (43%) Gaps:57/464 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 DDLEMRSFTDMNFNLYKL--------RMQW---NSLKSLPEVPFRGLSNVTYLSIGDNDLDEIPK 126
            ||.:..|....:.||.:|        :..|   |:|.|:|...|:.||::.:|::....|..:..
Human    89 DDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEP 153

  Fly   127 HALSHMPSLLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPKSLLILHLGRNQL 191
            .||..:.:|..|.:.|.::|::....|.....:.:|.|.:|.::||:.|.|              
Human   154 QALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLF-------------- 204

  Fly   192 ESLNGSLHDLHNLESLFINANNITSLDDELPDG-GQLRLLMAHNNRLERL-PANMAGMHSLETVH 254
            |.| |||.||:      :..|::..|.|....| |.||.|:...|||..| ||..:|:..|..:.
Human   205 EGL-GSLWDLN------LGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELD 262

  Fly   255 IHCNQLRSFD-RVLRNAVNLSEVMADNNELEYLAQDEFASCSKVETLQMGCNHIKSLNSSLLP-I 317
            :..|.||:.. .|......|.::..|.|.:..:|...|.....:..|.:..|.:..|.....| :
Human   263 LSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGL 327

  Fly   318 LKLKNANFSFNDIEEFSMAELHGLRSLKTLQLSSNRIQRLLPDPRGVQEL-MLVNLDLDNNRIDS 381
            |.|:....|.|.|..........|..|:.|||..|||::|.  .|..:.| .|..|.||:|::..
Human   328 LGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA--ERSFEGLGQLEVLTLDHNQLQE 390

  Fly   382 LN-GALAGLGNLRILNLAGNRLEHLQVGDFDGMIRLDILDLTGNQLAELKPLEMTLLPSLKILKV 445
            :. ||..||.|:.::||:||.|.:|....|.|:.:|..|.|.|:.|..::|...|.|..|:.|.:
Human   391 VKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFL 455

  Fly   446 AYNNITKL-EQDFKGLPVLCQANLTNNQISTISSELVTNTRCKNHNVPGKLEIHLDDNPIMCDVG 509
            ..|.:..: ||...||..|.:.:||:||::.:...|....        ||||..|        :.
Human   456 KDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL--------GKLEYLL--------LS 504

  Fly   510 LNELCRLMA 518
            .|.|..|.|
Human   505 RNRLAELPA 513

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ltlNP_001261524.1 leucine-rich repeat 65..86 CDD:275380 3/12 (25%)
LRR_8 86..145 CDD:290566 18/69 (26%)
leucine-rich repeat 87..110 CDD:275380 9/33 (27%)
leucine-rich repeat 111..134 CDD:275380 4/22 (18%)
leucine-rich repeat 135..158 CDD:275380 5/22 (23%)
LRR_8 158..214 CDD:290566 15/55 (27%)
leucine-rich repeat 159..180 CDD:275380 7/20 (35%)
leucine-rich repeat 181..203 CDD:275380 7/21 (33%)
leucine-rich repeat 204..226 CDD:275380 4/22 (18%)
LRR_RI 226..451 CDD:238064 69/229 (30%)
leucine-rich repeat 227..249 CDD:275380 10/22 (45%)
leucine-rich repeat 250..272 CDD:275380 5/22 (23%)
leucine-rich repeat 273..296 CDD:275380 5/22 (23%)
leucine-rich repeat 297..315 CDD:275380 3/17 (18%)
LRR_8 319..402 CDD:290566 29/84 (35%)
leucine-rich repeat 320..335 CDD:275378 4/14 (29%)
leucine-rich repeat 344..366 CDD:275380 9/21 (43%)
leucine-rich repeat 367..391 CDD:275380 10/25 (40%)
LRR_8 369..426 CDD:290566 22/57 (39%)
leucine-rich repeat 392..415 CDD:275380 8/22 (36%)
leucine-rich repeat 416..439 CDD:275380 8/22 (36%)
LRR_8 438..>479 CDD:290566 12/41 (29%)
leucine-rich repeat 440..462 CDD:275380 7/22 (32%)
leucine-rich repeat 463..483 CDD:275380 6/19 (32%)
IGFALSNP_001139478.1 LRRNT 78..116 CDD:214470 6/26 (23%)
leucine-rich repeat 95..113 CDD:275380 4/17 (24%)
leucine-rich repeat 114..137 CDD:275380 7/22 (32%)
leucine-rich repeat 138..161 CDD:275380 4/22 (18%)
LRR_8 141..196 CDD:290566 12/54 (22%)
leucine-rich repeat 162..185 CDD:275380 5/22 (23%)
LRR_8 184..244 CDD:290566 23/80 (29%)
leucine-rich repeat 186..209 CDD:275380 9/37 (24%)
leucine-rich repeat 210..233 CDD:275380 7/28 (25%)
leucine-rich repeat 234..257 CDD:275380 10/22 (45%)
LRR_8 257..316 CDD:290566 12/58 (21%)
leucine-rich repeat 258..281 CDD:275380 5/22 (23%)
leucine-rich repeat 282..305 CDD:275380 5/22 (23%)
leucine-rich repeat 306..324 CDD:275380 3/17 (18%)
LRR_8 336..388 CDD:290566 19/53 (36%)
leucine-rich repeat 354..377 CDD:275380 10/24 (42%)
LRR_8 377..433 CDD:290566 21/55 (38%)
leucine-rich repeat 378..401 CDD:275380 9/22 (41%)
leucine-rich repeat 402..423 CDD:275380 7/20 (35%)
LRR_8 425..484 CDD:290566 19/58 (33%)
leucine-rich repeat 426..447 CDD:275380 7/20 (35%)
leucine-rich repeat 450..473 CDD:275380 7/22 (32%)
leucine-rich repeat 474..497 CDD:275380 6/30 (20%)
LRR_8 476..532 CDD:290566 14/54 (26%)
leucine-rich repeat 498..519 CDD:275380 7/24 (29%)
leucine-rich repeat 522..543 CDD:275380
LRR_8 524..575 CDD:290566
leucine-rich repeat 546..565 CDD:275380
TPKR_C2 574..618 CDD:301599
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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