DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ltl and CG16974

DIOPT Version :9

Sequence 1:	NP_001261524.1	Gene:	ltl / 38845	FlyBaseID:	FBgn0268063	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster

Alignment Length:	705	Identity:	157/705 - (22%)
Similarity:	285/705 - (40%)	Gaps:	106/705 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLVYTVFHLASLQCSVRPEISPCTCETGKAW--------NHVELSCEKLESFNAVVDSLAN--KL 57
            ||:...|||..:..:|..::.....:.| .|        ..||:...:|.|... ||...|  ||
  Fly    66 SLLGYKFHLPFVGHAVDSDLDDSDSDEG-LWLDAADAGSESVEVEEHELPSVGH-VDPTGNVFKL 128

  Fly    58 NADTNIDLKITHSQLDDLEMRSFTDMNFNLYKLRM----QWNSLKSLPEVPFRGLSNVTYLSIGD 118
            |.: ::||:..:.:|  |..|| :.:|:|...|..    :.|.|| ||:     |.::...|...
  Fly   129 NCE-HVDLRRVNQEL--LSQRS-SHINYNQLMLAHVPADRSNPLK-LPQ-----LESLREFSWQS 183

  Fly   119 NDL-DEIPKHALSHMPS----LLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGS-- 176
            ::| ||......:..|.    :..|::...::..:.......::||..|.:..|   ||...|
  Fly   184 SELKDETLMELFTRQPRSFEYMERLNLAENRLECLHWAIPLAVRRVKVLEMSGN---RLSNCSLL 245

  Fly   177 ---FPKSLLILHLGRNQLESL-NGSLHDLHNLESLFINANNITSLDDELPDGG-QLRLLMAHNNR 236
               :.|.|..|||.|::|..| ...|.:|..|..|.::.|.:|.|..::..|. :|..|....||
  Fly   246 NLQYMKQLQELHLDRSELTYLPQRFLGELSELRMLNLSQNLLTELPRDIFVGALKLERLYLSGNR 310

  Fly   237 LERLPANM-AGMHSLETVHIHCNQLRSF-DRVLRNAVNLSEVMADNNELEYLAQDEFASCSKVET 299
            |..||..: .....|:.:.:..|:|.|| |........|.::....|:|:.:.:....|..::..
  Fly   311 LSVLPFMLFQTAADLQVLDLSDNRLLSFPDNFFARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQ 375

  Fly   300 LQMGCNHIKSLN----SSLLPILKLKNANFSFNDIEEFSMAELHGLRSLKTLQLSSNRIQRLLPD 360
            |.:..|.:..::    .||..:|.|   |.|.|::...|......|.:|:.|.||.|:.::|
  Fly   376 LDLSQNSLSVIDRKAFESLDHLLAL---NVSGNNLTLLSSIIFQSLHALRQLDLSRNQFKQL--- 434

  Fly   361 PRGV--QELMLVNLDLDNNRIDSLNGALA----GLGNLRILNLAGNRLEHLQVGDFDGMIRLDIL 419
            |.|:  ::..||.|.:|...|:..:..::    .|.:.::|    :||.:|.|
  Fly   435 PSGLFQRQRSLVLLRIDETPIEQFSNWISRYDESLVDPQVL----HRLRYLSV------------ 483

  Fly   420 DLTGNQLAELKPLEMTLL---PSLKILKVAYNNITKLEQDFKGLPVLCQANLTNNQISTISSELV 481
                .|..:|..|..||.   |:::.|.:|.|.:.:|.....||..|.:.::..|.:.::...:.
  Fly   484 ----QQNRKLTYLPATLFANTPNIRELLLAENGLLQLPTQISGLSRLQRLSVRGNSLGSLPENIK 544

  Fly   482 TNTRCKNHNVPGKLEIHLDDNPIMCDVGLNELCRLMAVQEARIR---GRSQCFENDQEVCTVLPM 543
            ...:....|:.|        |...||..:..|...:|.....:|   .::|...|.....|.|..
  Fly   545 ELRQLHYLNILG--------NEYQCDCSMYWLTAWLANTSTSLRHQMPQAQNHSNGSTNQTPLDS 601

  Fly   544 LYNVNLPIMVTNLKLTGREVPKPMVRVI------VPSLIKANNELLPPLIATLGNPVLISTDLVN 602
            ..:::..|.....:...|   ..|:||:      ||::::.:...:..|::|......||...|.
  Fly   602 YESIDHQIDALKCQYGYR---GDMLRVLSKLNCSVPTVVQFSEPKMHKLLSTAKLECQISGSPVP 663

  Fly   603 PVISPLPPPLLLATTTPPPPLPLPVESEVEKNESTTANPVPT----NYTQETTTT 653
            .:|...|...:|.....|...|:.::|:.:.::..:|..:..    :|.|....|
  Fly   664 DIIWVTPRNKILRHHADPDKRPIIIDSKEDAHQPPSAQELAALMDESYIQSLNWT 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380	6/20 (30%)
		LRR_8	86..145	CDD:290566	14/67 (21%)
		leucine-rich repeat	87..110	CDD:275380	7/26 (27%)
		leucine-rich repeat	111..134	CDD:275380	4/23 (17%)
		leucine-rich repeat	135..158	CDD:275380	1/22 (5%)
		LRR_8	158..214	CDD:290566	20/61 (33%)
		leucine-rich repeat	159..180	CDD:275380	6/25 (24%)
		leucine-rich repeat	181..203	CDD:275380	9/22 (41%)
		leucine-rich repeat	204..226	CDD:275380	6/22 (27%)
		LRR_RI	226..451	CDD:238064	56/239 (23%)
		leucine-rich repeat	227..249	CDD:275380	7/22 (32%)
		leucine-rich repeat	250..272	CDD:275380	6/22 (27%)
		leucine-rich repeat	273..296	CDD:275380	4/22 (18%)
		leucine-rich repeat	297..315	CDD:275380	3/21 (14%)
		LRR_8	319..402	CDD:290566	21/88 (24%)
		leucine-rich repeat	320..335	CDD:275378	4/14 (29%)
		leucine-rich repeat	344..366	CDD:275380	8/23 (35%)
		leucine-rich repeat	367..391	CDD:275380	6/27 (22%)
		LRR_8	369..426	CDD:290566	11/60 (18%)
		leucine-rich repeat	392..415	CDD:275380	5/22 (23%)
		leucine-rich repeat	416..439	CDD:275380	5/25 (20%)
		LRR_8	438..>479	CDD:290566	9/40 (23%)
		leucine-rich repeat	440..462	CDD:275380	6/21 (29%)
		leucine-rich repeat	463..483	CDD:275380	2/19 (11%)
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	1/21 (5%)
		leucine-rich repeat	229..252	CDD:275380	6/25 (24%)
		LRR_RI	<246..433	CDD:238064	49/189 (26%)
		LRR_8	251..311	CDD:290566	19/59 (32%)
		leucine-rich repeat	253..276	CDD:275380	9/22 (41%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		LRR_8	325..383	CDD:290566	12/57 (21%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		leucine-rich repeat	349..372	CDD:275380	4/22 (18%)
		LRR_RI	351..>557	CDD:238064	49/239 (21%)
		LRR_8	371..431	CDD:290566	16/62 (26%)
		leucine-rich repeat	373..396	CDD:275380	4/22 (18%)
		leucine-rich repeat	397..420	CDD:275380	7/25 (28%)
		leucine-rich repeat	421..444	CDD:275380	8/25 (32%)
		LRR_8	477..536	CDD:290566	18/74 (24%)
		leucine-rich repeat	478..502	CDD:275380	8/39 (21%)
		leucine-rich repeat	503..526	CDD:275380	6/22 (27%)
		Ig	<714..761	CDD:299845	1/5 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453818
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930