DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ltl and kek5

DIOPT Version :9

Sequence 1:	NP_001261524.1	Gene:	ltl / 38845	FlyBaseID:	FBgn0268063	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster

Alignment Length:	986	Identity:	173/986 - (17%)
Similarity:	327/986 - (33%)	Gaps:	328/986 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 CTCETGKAWNHVELSCE-KLESFNAVVDSLANKLNADTNIDLKITHSQLDDLEMRSFTDMNF-NL 87
            |.|:    ||..:.|.: |.::...:...::|::..     |...|:|:.:|....|..... |:
  Fly    46 CHCQ----WNSGKKSADCKNKALTKIPQDMSNEMQV-----LDFAHNQIPELRREEFLLAGLPNV 101

  Fly    88 YK------------------------LRMQWNSLKSLPEVPFRGLSNVTYLSIGDNDLDEIPKHA 128
            :|                        |.:..|.::.|....|.||..:..:.|.:|:::.:|.|.
  Fly   102 HKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVLPNHL 166

  Fly   129 LSHMPSLLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPKSLLILHLGRNQLES 193
            ..::..|..::....::|.||...|.|...::.:.|..|.::.|.:.:|.....::||      |
  Fly   167 FVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHL------S 225

  Fly   194 LNGSLH----DLHNLESLFINANNITSLDD-------------ELPDG---------GQLRLLMA 232
            |.|:..    :|.:.....|:....|...|             |:|..         |.:|..:.
  Fly   226 LQGNAWNCSCELQDFRDFAISKRLYTPPTDCQEPPQLRGKLWSEVPSENFACRPRILGSVRSFIE 290

  Fly   233 HNNRLERLPANMAGMHSLETVHIHCNQ-LRSFD---RVLRNAVNLSE------------------ 275
            .|:....||..:.|........::..: |:.:|   |||.:...:.|
  Fly   291 ANHDNISLPCRIVGSPRPNVTWVYNKRPLQQYDPRVRVLTSVEQMPEQPSQVLTSELRIVGVRAS 355

  Fly   276 ------VMADNN------ELEYLAQDEFA-SCSKVETLQMGCNHIKSLN-------------SSL 314
                  .:|||.      |.:.|...::| :.|..:.:.||.....:::             ::|
  Fly   356 DKGAYTCVADNRGGRAEAEFQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQTNMFLIICLIITTL 420

  Fly   315 LPILKLKNANFSFNDIEEFSMAELHGLRSLKTLQLSSNRIQRLLPDPRGVQELMLVNLDLDNNRI 379
            |.:|                      |.::.||.....||:....|...:....|::..:|...
  Fly   421 LLLL----------------------LVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSKMDKTH- 462

  Fly   380 DSLNGALAGLGNLRILNLAGNRLEHLQVGDFDGMIRLDILDLTGNQLAELKPLE----MTLLPS- 439
               ||::                       .:|.:   |:::..:.|.|:.|:|    .|.:.|
  Fly   463 ---NGSM-----------------------LEGSV---IMEMQKSLLNEVNPVEKPPRRTDIESV 498

  Fly   440 ------LKILKVAYNNITKLEQDFKGLPVLCQANLTNNQ--ISTISSELVTNTRCKNHNVPGKLE 496
                  |:|.|...::...:            ||.:.::  :|...|:..|..|.::..|.
  Fly   499 DGGDDVLEIKKTLLDDTVYV------------ANHSRDEEAVSVAMSDTTTTPRSRHTYVD---- 547

  Fly   497 IHLDDNPIMCDVGLNELCRLMAVQEARIRGRSQCFENDQEVCTVLP--MLYNVNLPIMVTNLKLT 559
                      |...|.|...:....||:...|...::.|   :.:|  ::|.:..|..:|:
  Fly   548 ----------DAYANSLPPDLLAFPARVPPTSPSMQSSQ---SNIPDQVIYGIRSPPSLTS---- 595

  Fly   560 GREVPKPMVRVIVPSLIKANNELLPPL--IATLGNP-----VLIST------------------- 598
                  |:...:.|..|.....:..|.  ..||.:|     .||:|
  Fly   596 ------PVYTHMTPHGIYGTKTMTAPHNGFMTLQHPKSRNLALIATTNSSRQHQHHHQLQQQQQH 654

  Fly   599 ------------DLVNPVISPLPPPLLLATTTPPPPLPL---PVESEVEKNESTTANPVPTNYTQ 648
                        ...:|          ||||:|..|.|:   |....|.|....|....|
  Fly   655 HHHHQQQQQQQQQQQHP----------LATTSPFLPAPVVYSPATGVVMKQGYMTIPRKP----- 704

  Fly   649 ETTTTTSTTTTTTTTETSSQVAPIEIITTTAPTTTTTST----------------TTPKPNETLP 697
             ...:.:.:|:......|.|::..:..|:..|:.|.|:|                ||...|.||.
  Fly   705 -RAPSWAPSTSGAAGHGSIQLSEFQSPTSPNPSETGTATTAELQAEPVYDNLGLRTTAGGNSTLN 768

  Fly   698 VI------------VELQD---PNPPDTTVNQTALVPPVVLDPL------QQDLERERERERERE 741
            :.            ..::|   |..|..|...:|.....:.:|:      ||.|:::::::::|
  Fly   769 LTKIAGSQGGAGQQYSMRDRPLPATPSLTSVSSATNASKIYEPIHELIQQQQQLQQQQQQQQQR- 832

  Fly   742 LERDLDHEAVAKTEYETVEYIP--NLVQPPVGSDALTPPPSKANALEEDSESVHSNSVHAEYPHA 804
             ...:|.|.:.....:.:..:|  ::....:|..|...|.|.|..    |.|..|:|  .:.|.|
  Fly   833 -LGSMDTEPLYGVRQQGITILPGSSISGAGLGHAAYLSPGSGAAV----SPSHASSS--GDSPKA 890

  Fly   805 AQSLQIPEEPP 815
            |   :||..||
  Fly   891 A---KIPPRPP 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380	5/21 (24%)
		LRR_8	86..145	CDD:290566	13/82 (16%)
		leucine-rich repeat	87..110	CDD:275380	7/46 (15%)
		leucine-rich repeat	111..134	CDD:275380	4/22 (18%)
		leucine-rich repeat	135..158	CDD:275380	6/22 (27%)
		LRR_8	158..214	CDD:290566	11/59 (19%)
		leucine-rich repeat	159..180	CDD:275380	4/20 (20%)
		leucine-rich repeat	181..203	CDD:275380	6/25 (24%)
		leucine-rich repeat	204..226	CDD:275380	5/43 (12%)
		LRR_RI	226..451	CDD:238064	44/283 (16%)
		leucine-rich repeat	227..249	CDD:275380	5/21 (24%)
		leucine-rich repeat	250..272	CDD:275380	5/25 (20%)
		leucine-rich repeat	273..296	CDD:275380	7/53 (13%)
		leucine-rich repeat	297..315	CDD:275380	2/30 (7%)
		LRR_8	319..402	CDD:290566	10/82 (12%)
		leucine-rich repeat	320..335	CDD:275378	0/14 (0%)
		leucine-rich repeat	344..366	CDD:275380	5/21 (24%)
		leucine-rich repeat	367..391	CDD:275380	4/23 (17%)
		LRR_8	369..426	CDD:290566	6/56 (11%)
		leucine-rich repeat	392..415	CDD:275380	1/22 (5%)
		leucine-rich repeat	416..439	CDD:275380	6/26 (23%)
		LRR_8	438..>479	CDD:290566	7/49 (14%)
		leucine-rich repeat	440..462	CDD:275380	3/21 (14%)
		leucine-rich repeat	463..483	CDD:275380	4/21 (19%)
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	15/88 (17%)
		leucine-rich repeat	76..100	CDD:275380	5/28 (18%)
		LRR_8	99..159	CDD:290566	10/59 (17%)
		leucine-rich repeat	101..124	CDD:275380	1/22 (5%)
		LRR	122..145	CDD:197688	4/22 (18%)
		leucine-rich repeat	125..148	CDD:275380	6/22 (27%)
		LRR_8	148..207	CDD:290566	12/58 (21%)
		leucine-rich repeat	149..172	CDD:275380	4/22 (18%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR_8	197..>229	CDD:290566	8/37 (22%)
		leucine-rich repeat	197..220	CDD:275380	4/22 (18%)
		LRRCT	229..277	CDD:214507	6/47 (13%)
		Ig	296..376	CDD:143165	13/79 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453741
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930