Protein Alignment ltl and Lgr6

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_001405234.1
• Gene: Lgr6 / 329252
• MGIID: 2441805
• Length: 1004
• Species: Mus musculus
• Alignment Length: 646
• Identity: 140/646 - (21%)
• Similarity: 229/646 - (35%)
• Gaps: 239/646 - (36%)

  Fly    23 SPCTCETGKAWNHVELSCEKLESFNAVVDSLANKLNAD-TNIDLKITHSQLD------DLEMRSF 80
            :||.|:.                     |.:  .|:|| :.:.|.:..:.||      ||.|.:.
Mouse    37 APCHCQE---------------------DGI--MLSADCSELGLSVVPADLDPLTAYLDLSMNNL 78

  Fly    81 TDMNFNLY-------KLRMQWNSLKSLPEVPFRGLSNVTYLSIGDNDLDEIPKHALSHMPSLLTL 138
            |::...|:       :||:..|.|..:|...|.||.::..|.:..|.|..||..||..:|||.:|
Mouse    79 TELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSL 143

  Fly   139 DIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLD---RGSFP---------------------- 178
            .:....|..|.:..|.|:..:.:|.|..|.:|.:.   ..:.|
Mouse   144 RLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNHIRHIPDYAFQN 208

  Fly   179 -KSLLILHLGRNQLESL-NGSLHDLHNLESLF--------------------------------- 208
             .||::|||..|:::.: ..|...|||||:|.
Mouse   209 LTSLVVLHLHNNRIQHVGTHSFEGLHNLETLVFFLFCSPERFLGEPAGEGRCGGGGAAARMKGGR 273

  Fly   209 ----INANNITSLDDELPDGGQLRLLMAHNNRLERLPAN-MAGMHSLETVHIHCNQLRSFDRVLR 268
                :|.|.:......:...|:|:.|..|||.::.:|.. ..|...|:|:|.:
Mouse   274 NDRDLNYNELQEFPLAIRTLGRLQELGFHNNNIKAIPEKAFMGSPLLQTIHFY------------ 326

  Fly   269 NAVNLSEVMADNNELEYLAQDEFASCSKVETLQMGCNHIKSLNSSLLPILKLKNANFSFNDIEEF 333
                       :|.::::.:..|...||:.||        |||.:              .||:||
Mouse   327 -----------DNPIQFVGRSAFQYLSKLHTL--------SLNGA--------------TDIQEF 358

  Fly   334 SMAELHGLRSLKTLQLSSNRIQRLLPDPRGVQELMLVNLDLDNNRIDSLNGALAGLGNLRILNLA 398
              .:|.|..||:.|.|:...| ||||.                       |....|..||||.|:
Mouse   359 --PDLKGTTSLEILTLTRAGI-RLLPP-----------------------GVCQQLPRLRILELS 397

  Fly   399 GNRLEHLQVGDFDGMIRLDILDLTGNQLAELKPLEMTLLPSLKILKVAYNNITKLEQD-FKGLPV 462
            .|::|.|.  ......:|:.:.|..|::.|:.....:.|.||:.|.:::|.|..:..: |..|..
Mouse   398 HNQIEELP--SLHRCQKLEEIGLRHNRIKEIGADTFSQLGSLQALDLSWNAIRAIHPEAFSTLRS 460

  Fly   463 LCQANLTNNQISTISSELVTNTRCKNHNVPGKLEIHLDDNPIMCDVGLNELCRLMAVQEARIRGR 527
            |.:.:||:||::|:                          |:   .||..|..|      :::|.
Mouse   461 LVKLDLTDNQLTTL--------------------------PL---AGLGGLMHL------KLKGN 490

  Fly   528 ---SQCFENDQEVCTVLPMLYNVNLP---------IMVTNLKLTGR-----------EVPK 565
               ||.|..|.     .|.|..:.:|         |..:..|.:|:           |.||
Mouse   491 LALSQAFSKDS-----FPKLRILEVPYAYQCCAYGICASFFKTSGQWQAEDFHPEEEEAPK 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	113/489 (23%)
		leucine-rich repeat	65..86	CDD:275380	7/26 (27%)
		leucine-rich repeat	87..110	CDD:275380	9/29 (31%)
		leucine-rich repeat	111..134	CDD:275380	7/22 (32%)
		leucine-rich repeat	135..158	CDD:275380	6/22 (27%)
		leucine-rich repeat	159..180	CDD:275380	5/46 (11%)
		leucine-rich repeat	181..203	CDD:275380	7/22 (32%)
		leucine-rich repeat	204..226	CDD:275380	5/58 (9%)
		leucine-rich repeat	227..249	CDD:275380	7/22 (32%)
		leucine-rich repeat	250..272	CDD:275380	3/21 (14%)
		leucine-rich repeat	273..296	CDD:275380	2/22 (9%)
		leucine-rich repeat	297..315	CDD:275380	5/17 (29%)
		leucine-rich repeat	320..335	CDD:275378	4/14 (29%)
		leucine-rich repeat	344..366	CDD:275380	8/21 (38%)
		leucine-rich repeat	367..391	CDD:275380	2/23 (9%)
		leucine-rich repeat	392..415	CDD:275380	8/22 (36%)
		leucine-rich repeat	416..439	CDD:275380	5/22 (23%)
		leucine-rich repeat	440..462	CDD:275380	6/22 (27%)
		leucine-rich repeat	463..483	CDD:275380	6/19 (32%)
Lgr6	NP_001405234.1	LRR	<51..350	CDD:443914	70/329 (21%)
		leucine-rich repeat	70..91	CDD:275380	5/20 (25%)
		leucine-rich repeat	92..115	CDD:275380	8/22 (36%)
		leucine-rich repeat	116..139	CDD:275380	7/22 (32%)
		leucine-rich repeat	140..163	CDD:275380	6/22 (27%)
		leucine-rich repeat	164..187	CDD:275380	4/22 (18%)
		leucine-rich repeat	188..211	CDD:275380	0/22 (0%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		leucine-rich repeat	236..295	CDD:275380	5/58 (9%)
		LRR	277..>508	CDD:443914	77/343 (22%)
		leucine-rich repeat	296..319	CDD:275380	7/22 (32%)
		leucine-rich repeat	320..341	CDD:275380	5/43 (12%)
		leucine-rich repeat	344..385	CDD:275380	21/88 (24%)
		leucine-rich repeat	391..412	CDD:275380	8/22 (36%)
		leucine-rich repeat	413..436	CDD:275380	5/22 (23%)
		leucine-rich repeat	437..458	CDD:275380	5/20 (25%)
		leucine-rich repeat	461..481	CDD:275380	9/48 (19%)
		7tmA_LGR6	599..875	CDD:320484
		TM helix 1	600..626	CDD:320484
		TM helix 2	634..659	CDD:320484
		TM helix 3	679..709	CDD:320484
		TM helix 4	721..743	CDD:320484
		TM helix 5	765..794	CDD:320484
		TM helix 6	803..833	CDD:320484
		TM helix 7	843..868	CDD:320484