Protein Alignment ltl and Rtn4rl2

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_852045.1
• Gene: Rtn4rl2 / 311169
• RGDID: 727797
• Length: 420
• Species: Rattus norvegicus
• Alignment Length: 344
• Identity: 83/344 - (24%)
• Similarity: 146/344 - (42%)
• Gaps: 80/344 - (23%)

  Fly    20 PEISP-----CTCETGKAWNHVELSCEKLESFNAVVDSL---ANKLNADTNIDLKITHSQLDDLE 76
            |.::|     |||.:...    .:||: ..:|::|..||   ..:|....|:
  Rat    25 PPVTPSCPMLCTCYSSPP----TVSCQ-ANNFSSVPLSLPPSTQRLFLQNNL------------- 71

  Fly    77 MRSFTDMNF--NLYKLRMQWNSLKSLPEVPFRGLSNVTYLSIGDNDLDEIPKHALSHMPSLLTLD 139
            :||.....|  ||..|.:..|:|.::....||.|..:..|.:|||      :|
  Rat    72 IRSLRPGTFGPNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDN------RH------------ 118

  Fly   140 IGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPKSLLILHLGRNQLESLNGSL-HDLHN 203
                 :|:::.:.|:|::|:.:                      |||.|.||.||.|:: ..|.:
  Rat   119 -----LRSLEPDTFQGLERLQS----------------------LHLYRCQLSSLPGNIFRGLVS 156

  Fly   204 LESLFINANNITSLDDEL-PDGGQLRLLMAHNNRLERLPANM-AGMHSLETVHIHCNQLRSFDRV 266
            |:.|::..|::..|.|:| .|...|..|..|.|||..|..:: .|:.||:.:.:|.|:|:...|.
  Rat   157 LQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRA 221

  Fly   267 LRNAVN-LSEVMADNNELEYLAQDEFASCSKVETLQMGCNHIKSLNSSLLPILK-LKNANFSFND 329
            ..:.:: |:.:...||.|..|..:..|....:|.|::..|. .:.:....|:.. .:.|..|.:|
  Rat   222 AFHGLSRLTILYLFNNSLASLPGEALADLPALEFLRLNANP-WACDCRARPLWAWFQRARVSSSD 285

  Fly   330 IEEFSMAELHGLRSLKTLQ 348
            :...:..|..| |.|:||:
  Rat   286 VTCATPPERQG-RDLRTLR 303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	70/291 (24%)
		leucine-rich repeat	65..86	CDD:275380	3/22 (14%)
		leucine-rich repeat	87..110	CDD:275380	7/22 (32%)
		leucine-rich repeat	111..134	CDD:275380	5/22 (23%)
		leucine-rich repeat	135..158	CDD:275380	3/22 (14%)
		leucine-rich repeat	159..180	CDD:275380	0/20 (0%)
		leucine-rich repeat	181..203	CDD:275380	10/22 (45%)
		leucine-rich repeat	204..226	CDD:275380	7/22 (32%)
		leucine-rich repeat	227..249	CDD:275380	8/22 (36%)
		leucine-rich repeat	250..272	CDD:275380	5/21 (24%)
		leucine-rich repeat	273..296	CDD:275380	6/22 (27%)
		leucine-rich repeat	297..315	CDD:275380	3/17 (18%)
		leucine-rich repeat	320..335	CDD:275378	3/14 (21%)
		leucine-rich repeat	344..366	CDD:275380	3/5 (60%)
		leucine-rich repeat	367..391	CDD:275380
		leucine-rich repeat	392..415	CDD:275380
		leucine-rich repeat	416..439	CDD:275380
		leucine-rich repeat	440..462	CDD:275380
		leucine-rich repeat	463..483	CDD:275380
Rtn4rl2	NP_852045.1	LRR	<55..>261	CDD:443914	63/263 (24%)
		LRR 1	61..82		5/33 (15%)
		leucine-rich repeat	62..83	CDD:275380	5/33 (15%)
		LRR 2	83..104		6/20 (30%)
		leucine-rich repeat	84..107	CDD:275380	7/22 (32%)
		LRR 3	107..129		7/44 (16%)
		leucine-rich repeat	108..132	CDD:275380	8/46 (17%)
		LRR 4	132..153		10/42 (24%)
		leucine-rich repeat	133..156	CDD:275380	10/44 (23%)
		LRR 5	156..177		6/20 (30%)
		leucine-rich repeat	157..180	CDD:275380	7/22 (32%)
		LRR 6	180..201		7/20 (35%)
		leucine-rich repeat	181..204	CDD:275380	8/22 (36%)
		LRR 7	204..225		6/20 (30%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		LRR 8	228..249		5/20 (25%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRRCT	261..311	CDD:214507	11/45 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	286..390		6/19 (32%)
		PHA03247	289..>369	CDD:223021	6/16 (38%)
		Important for interaction with MAG. /evidence=ECO:0000269|PubMed:19420245	315..327