DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ltl and Mfhas1

DIOPT Version :9

Sequence 1:	NP_001261524.1	Gene:	ltl / 38845	FlyBaseID:	FBgn0268063	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	XP_006253286.1	Gene:	Mfhas1 / 306508	RGDID:	1308812	Length:	1048	Species:	Rattus norvegicus

Alignment Length:	391	Identity:	104/391 - (26%)
Similarity:	172/391 - (43%)	Gaps:	46/391 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 NSLKSLPEVPF----RGLSNVTYLSIGDNDLDEIPKHALSHMPSLLTLDIGRCKIRAVQQEDFRG 155
            :||:| |:.|.    ..:.::..|::|:|.|:::|:...|.:.||..|.:.|.:...:.......
  Rat    42 DSLES-PDAPQLVLPANIGDIEVLNLGNNGLEDVPEGLGSALGSLRVLVLRRNRFARLPPAVAEL 105

  Fly   156 IQRVTNLILVSNIITRL--DRGSFPKSLLILHLGRNQLESLNGSLHDLHNLESLFINANNITSLD 218
            ...:|.|.:..|.:|.|  :..|..:.|..|:|..|||.:|...|..|.:||.|.::.|.:..|.
  Rat   106 GHHLTELDVSHNRLTILGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLP 170

  Fly   219 DELPDGGQLRLLMAHNNRLERLPANMAGMHSLETVHIHCNQLRSFDRVLRNAVNLSEVMADNNEL 283
            |.......||.|...:|:|...|..:..:.:||.:.:..|:||.....:.....|..:.....||
  Rat   171 DSFSCLNHLRTLDVDHNQLTAFPQQLLQLAALEELDVSSNRLRGLPEDISALRALKILWLSGAEL 235

  Fly   284 EYLAQDEFASCSKVETLQMGCNHIKSLNSSLLPILKLKNANFSFNDIEEFSMAELHGLRSLKTLQ 348
            ..|... |...:.:|:|.:..|.:::|......:.:||..|.|.|..|||..|
  Rat   236 GTLPSG-FCELASLESLMLDNNGLQALPDEFSRLQRLKMLNLSSNLFEEFPAA------------ 287

  Fly   349 LSSNRIQRLLPDPRGVQELMLVNLDLDNNRIDSLNGALAGLGNLRILNLAGNRLEHLQVGDFDGM 413
                    ||| ..|::||.     |..|::.|:...:||||.|..|.|..||:.:|.    |.:
  Rat   288 --------LLP-LAGLEELY-----LSRNQLTSVPSLIAGLGRLLTLWLDNNRIRYLP----DSI 334

  Fly   414 IRLDILD---LTGNQLAELKPLEMTLLPSLKILKVAYNNITK--LEQDFKGLPVLC--QANLTNN 471
            :.|..|:   |.|||:|.| |.....|..:.:.|:..|.:.:  .|...||:|.:.  |..|.::
  Rat   335 VELTGLEELVLQGNQIAVL-PDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHS 398

  Fly   472 Q 472
            |
  Rat   399 Q 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380
		LRR_8	86..145	CDD:290566	15/53 (28%)
		leucine-rich repeat	87..110	CDD:275380	5/18 (28%)
		leucine-rich repeat	111..134	CDD:275380	6/22 (27%)
		leucine-rich repeat	135..158	CDD:275380	3/22 (14%)
		LRR_8	158..214	CDD:290566	19/57 (33%)
		leucine-rich repeat	159..180	CDD:275380	6/22 (27%)
		leucine-rich repeat	181..203	CDD:275380	9/21 (43%)
		leucine-rich repeat	204..226	CDD:275380	6/21 (29%)
		LRR_RI	226..451	CDD:238064	61/227 (27%)
		leucine-rich repeat	227..249	CDD:275380	6/21 (29%)
		leucine-rich repeat	250..272	CDD:275380	5/21 (24%)
		leucine-rich repeat	273..296	CDD:275380	5/22 (23%)
		leucine-rich repeat	297..315	CDD:275380	4/17 (24%)
		LRR_8	319..402	CDD:290566	26/82 (32%)
		leucine-rich repeat	320..335	CDD:275378	8/14 (57%)
		leucine-rich repeat	344..366	CDD:275380	4/21 (19%)
		leucine-rich repeat	367..391	CDD:275380	7/23 (30%)
		LRR_8	369..426	CDD:290566	19/59 (32%)
		leucine-rich repeat	392..415	CDD:275380	7/22 (32%)
		leucine-rich repeat	416..439	CDD:275380	10/25 (40%)
		LRR_8	438..>479	CDD:290566	9/39 (23%)
		leucine-rich repeat	440..462	CDD:275380	5/23 (22%)
		leucine-rich repeat	463..483	CDD:275380	3/12 (25%)
Mfhas1	XP_006253286.1	LRR	42..338	CDD:227223	85/327 (26%)
		leucine-rich repeat	61..84	CDD:275380	6/22 (27%)
		leucine-rich repeat	85..108	CDD:275380	3/22 (14%)
		leucine-rich repeat	109..132	CDD:275380	6/22 (27%)
		leucine-rich repeat	133..155	CDD:275380	9/21 (43%)
		leucine-rich repeat	156..178	CDD:275380	6/21 (29%)
		leucine-rich repeat	179..224	CDD:275380	11/44 (25%)
		leucine-rich repeat	225..247	CDD:275380	5/22 (23%)
		leucine-rich repeat	248..270	CDD:275380	4/21 (19%)
		leucine-rich repeat	271..293	CDD:275380	12/42 (29%)
		leucine-rich repeat	294..316	CDD:275380	8/26 (31%)
		leucine-rich repeat	317..339	CDD:275380	8/25 (32%)
		leucine-rich repeat	340..360	CDD:275380	8/20 (40%)
		P-loop_NTPase	405..>548	CDD:422963
		COR	656..902	CDD:406489
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000