Protein Alignment ltl and Elfn1

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_001099383.1
• Gene: Elfn1 / 288512
• RGDID: 1308787
• Length: 829
• Species: Rattus norvegicus
• Alignment Length: 531
• Identity: 120/531 - (22%)
• Similarity: 185/531 - (34%)
• Gaps: 140/531 - (26%)

  Fly   369 LVNLDLDNNRIDSLN-GALAGLGNLRILNLAGNRLEHLQVGDFDGMIRLDILDLTGNQLAELKPL 432
            :|:|.|:.|||.|:. .:|:..|||..|||..|.:.:::.|.|.|...|.:|.|..|:|..|...
  Rat    62 IVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEG 126

  Fly   433 EMTLLPSLKILKVAYNNI-TKLEQDFKGLPVLCQANLTNNQISTISSELVTNTRCKNHNVPGKLE 496
            .:..|..|:.|.:..|.| ..:...|...|.:...:|:.|:|..:.|.......        ||.
  Rat   127 MLRGLSKLEYLYLQANLIEVVMASAFWECPNIVNIDLSMNRIQQLGSGTFAGLT--------KLS 183

  Fly   497 I-HLDDNPIMCDVGLNELCRLMA--VQEARIRGRSQC-----------------------FENDQ 535
            : .:..||..|...|....|.:|  ....:...|.||                       ....|
  Rat   184 VCEIYSNPFYCSCELLGFLRWLAAFTNATQTHDRVQCESPPVYAGYFLLGQGRHGHQRSILSKLQ 248

  Fly   536 EVCTVLPMLYNVNLPIMVTNLKLTGREVPKPMVRVIVPSLIKANNELLPPLIATLGNPVLISTDL 600
            .|||.......|..|             |:|     ||...:..:...||
  Rat   249 SVCTEGSYTAEVLGP-------------PRP-----VPGRSQPGHSPPPP--------------- 280

  Fly   601 VNPVISPLP------------PPLLLATTTPP-----PPLPLPVESEVEKNEST--TANPVPTN- 645
             .|..|.:|            .||::.||..|     |.:.:   .::.:|.:|  ...|.|.|
  Rat   281 -PPEPSDMPCADDECFSGDGTTPLVVLTTLVPQTEARPSMKV---KQLTQNSATIMVQLPSPFNR 341

  Fly   646 -YTQETTTTTSTTTTTTTTETSSQVAPIEIITTTAPTTTTTSTTT-PKPNETLPVIVELQDPNPP 708
             ||.|....:.:.|.:..|:...::....:.|.|..|....||:: ...|.|...|...:.|:||
  Rat   342 MYTLEQYNNSKSFTVSKLTQPQEEIRLTNLYTLTNYTYCVVSTSSGTHHNHTCLTICLPKPPSPP 406

  Fly   709 DTTVNQTALVPPV------------VLDPLQQDLERERERERERELERDLDHEAVA-------KT 754
            ....:.:.....:            ||..:...|.:.|.:|.:.:       :|||       ||
  Rat   407 GPVPSPSTATHYIMTILGCLFGMVLVLGAVYYCLRKRRRQEEKHK-------KAVAAAAGSLKKT 464

  Fly   755 EYETVEYIPN--------LVQPP-VGSDALTPPP--SKANALEEDSESVHSNSVHAEYPHAAQSL 808
            ..| ::|.|.        |.|.| :|.:|:|..|  ..|.:..|..:.|.|    .|.|.|.:..
  Rat   465 IIE-LKYGPEIEAPGLAPLTQGPLLGPEAVTRIPYLPAATSDVEQYKLVES----GETPKATKGN 524

  Fly   809 QI---PEEPPE 816
            .|   ..||||
  Rat   525 YIEVRTGEPPE 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	34/108 (31%)
		leucine-rich repeat	65..86	CDD:275380
		leucine-rich repeat	87..110	CDD:275380
		leucine-rich repeat	111..134	CDD:275380
		leucine-rich repeat	135..158	CDD:275380
		leucine-rich repeat	159..180	CDD:275380
		leucine-rich repeat	181..203	CDD:275380
		leucine-rich repeat	204..226	CDD:275380
		leucine-rich repeat	227..249	CDD:275380
		leucine-rich repeat	250..272	CDD:275380
		leucine-rich repeat	273..296	CDD:275380
		leucine-rich repeat	297..315	CDD:275380
		leucine-rich repeat	320..335	CDD:275378
		leucine-rich repeat	344..366	CDD:275380
		leucine-rich repeat	367..391	CDD:275380	8/22 (36%)
		leucine-rich repeat	392..415	CDD:275380	8/22 (36%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		leucine-rich repeat	440..462	CDD:275380	5/22 (23%)
		leucine-rich repeat	463..483	CDD:275380	4/19 (21%)
Elfn1	NP_001099383.1	LRR	40..>190	CDD:443914	37/135 (27%)
		leucine-rich repeat	65..85	CDD:275378	7/19 (37%)
		LRR_8	85..144	CDD:404697	19/58 (33%)
		leucine-rich repeat	86..109	CDD:275378	8/22 (36%)
		leucine-rich repeat	110..133	CDD:275378	7/22 (32%)
		leucine-rich repeat	134..157	CDD:275378	5/22 (23%)
		leucine-rich repeat	158..171	CDD:275378	3/12 (25%)
		LRRCT	190..>228	CDD:214507	9/37 (24%)