Protein Alignment ltl and Lrrtm4

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_001128215.1
• Gene: Lrrtm4 / 243499
• MGIID: 2389180
• Length: 591
• Species: Mus musculus
• Alignment Length: 442
• Identity: 100/442 - (22%)
• Similarity: 170/442 - (38%)
• Gaps: 139/442 - (31%)

  Fly    76 EMRSFTDMNFNL----YKLRMQWNSLKSLPEVPFRGLSNVTYLSIGDNDLDEIPKHALSHMPSLL 136
            |..:|.|:..|:    ..|.:::||::.|....|.||:.:.:|.:..|
Mouse    49 ESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHN----------------- 96

  Fly   137 TLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPKSLLILHLGRNQLESLNGSLHDL 201
                   .|.:|.::.|:||:|:..|||.||.||            .||         |.:.|.:
Mouse    97 -------YISSVDEDAFQGIRRLKELILSSNKIT------------YLH---------NKTFHPV 133

  Fly   202 HNLESLFINANNITSLDDELPDGGQLRLLMAHNNRLERLPANMAGMHSLETVHIHCNQLRSFD-R 265
            .||.:|.::.|.:.:|..|                      ...|:..|..:|:..|.|::.. |
Mouse   134 PNLRNLDLSYNKLQTLQSE----------------------QFKGLRKLIILHLRSNSLKTVPIR 176

  Fly   266 VLRNAVNLSEVMADNNELEYLAQDEFASCSKVETLQMGCNHIKSLN-SSLLPILKLKNANFSFND 329
            |                        |..|..::.|.:|.|.::||: ::...:||||..:...|.
Mouse   177 V------------------------FQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQ 217

  Fly   330 IEEFSMAELHGLRSLKTLQLSSNRIQRLLPDPRGVQELM------LVNLDLDNNRIDSLN-GALA 387
            ..:.:.|....|.:|:::.|..|||       |.|.:.:      |..|||..|.|.::. |...
Mouse   218 FSKINFAHFPRLFNLRSIYLQWNRI-------RSVSQGLTWTWSSLHTLDLSGNDIQAIEPGTFK 275

  Fly   388 GLGNLRILNLAGNRLEHLQVGDFDGMIRLDILDLTGNQLAELKPLEMTLLPSLKILKVAYNNITK 452
            .|.||:.|||..|:|.::.....:..|.|..:.|:||    :.....::.|....||
Mouse   276 CLPNLQKLNLDSNKLTNVSQETVNAWISLISITLSGN----MWECSRSICPLFYWLK-------- 328

  Fly   453 LEQDFKG---LPVLC------QANLTNNQIST--ISSEL-VTNTRCKNHNVP 492
               :|||   ..::|      |....::.:.|  |.|:: |.||. ::|..|
Mouse   329 ---NFKGNKESTMICAGPKHIQGEKVSDAVETYNICSDVQVVNTE-RSHLAP 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	93/423 (22%)
		leucine-rich repeat	65..86	CDD:275380	3/9 (33%)
		leucine-rich repeat	87..110	CDD:275380	7/26 (27%)
		leucine-rich repeat	111..134	CDD:275380	2/22 (9%)
		leucine-rich repeat	135..158	CDD:275380	5/22 (23%)
		leucine-rich repeat	159..180	CDD:275380	7/20 (35%)
		leucine-rich repeat	181..203	CDD:275380	4/21 (19%)
		leucine-rich repeat	204..226	CDD:275380	5/21 (24%)
		leucine-rich repeat	227..249	CDD:275380	1/21 (5%)
		leucine-rich repeat	250..272	CDD:275380	6/22 (27%)
		leucine-rich repeat	273..296	CDD:275380	2/22 (9%)
		leucine-rich repeat	297..315	CDD:275380	5/18 (28%)
		leucine-rich repeat	320..335	CDD:275378	3/14 (21%)
		leucine-rich repeat	344..366	CDD:275380	7/21 (33%)
		leucine-rich repeat	367..391	CDD:275380	8/30 (27%)
		leucine-rich repeat	392..415	CDD:275380	6/22 (27%)
		leucine-rich repeat	416..439	CDD:275380	4/22 (18%)
		leucine-rich repeat	440..462	CDD:275380	5/24 (21%)
		leucine-rich repeat	463..483	CDD:275380	6/28 (21%)
Lrrtm4	NP_001128215.1	leucine-rich repeat	44..62	CDD:275380	4/12 (33%)
		leucine-rich repeat	65..87	CDD:275380	7/21 (33%)
		LRR	67..>312	CDD:443914	78/342 (23%)
		leucine-rich repeat	88..111	CDD:275380	7/46 (15%)
		leucine-rich repeat	112..135	CDD:275380	11/43 (26%)
		leucine-rich repeat	136..159	CDD:275380	6/44 (14%)
		leucine-rich repeat	160..183	CDD:275380	8/46 (17%)
		leucine-rich repeat	184..207	CDD:275380	5/22 (23%)
		leucine-rich repeat	208..231	CDD:275380	5/22 (23%)
		leucine-rich repeat	232..255	CDD:275380	7/29 (24%)
		leucine-rich repeat	256..279	CDD:275380	8/22 (36%)
		leucine-rich repeat	304..316	CDD:275378	4/15 (27%)