Protein Alignment ltl and Elfn1

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_780731.1
• Gene: Elfn1 / 243312
• MGIID: 2442479
• Length: 828
• Species: Mus musculus
• Alignment Length: 531
• Identity: 117/531 - (22%)
• Similarity: 187/531 - (35%)
• Gaps: 139/531 - (26%)

  Fly   369 LVNLDLDNNRIDSLN-GALAGLGNLRILNLAGNRLEHLQVGDFDGMIRLDILDLTGNQLAELKPL 432
            :|:|.|:.|||.|:. .:|:..|||..|||..|.:.:::.|.|.|...|.:|.|..|:|..|...
Mouse    62 IVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEG 126

  Fly   433 EMTLLPSLKILKVAYNNI-TKLEQDFKGLPVLCQANLTNNQISTISSELVTNTRCKNHNVPGKLE 496
            .:..|..|:.|.:..|.| ..:...|...|.:...:|:.|:|..:.|.......        ||.
Mouse   127 MLRGLSKLEYLYLQANLIEVVMASAFWECPNIVNIDLSMNRIQQLGSGTFAGLT--------KLS 183

  Fly   497 I-HLDDNPIMCDVGLNELCRLMA--VQEARIRGRSQC-----------------------FENDQ 535
            : .:..||..|...|....|.:|  ....:...|.||                       ....|
Mouse   184 VCEIYSNPFYCSCELLGFLRWLAAFTNATQTHDRVQCESPPVYAGYFLLGQGRHGHQRSILSKLQ 248

  Fly   536 EVCTVLPMLYNVNLPIMVTNLKLTGREVPKPMVRVIVPSLIKANNELLPPLIATLGNPVLISTDL 600
            .|||.......|..|             |:|     ||...:..:...||
Mouse   249 SVCTEGSYTAEVLGP-------------PRP-----VPGRSQPGHSPPPP--------------- 280

  Fly   601 VNPVISPLP------------PPLLLATTTPP-----PPLPLPVESEVEKNEST--TANPVPTN- 645
             .|..|.:|            .||::.||..|     |.:.:   .::.:|.:|  ...|.|.|
Mouse   281 -PPEPSDMPCADDECFSGDGTTPLVILTTLVPQTEARPSMKV---KQLTQNSATIMVQLPSPFNR 341

  Fly   646 -YTQETTTTTSTTTTTTTTETSSQVAPIEIITTTAPTTTTTSTTT-PKPNETLPVIVELQDPNPP 708
             ||.|....:.:.|.:..|:...::....:.|.|..|....||:: ...|.|...|...:.|:||
Mouse   342 MYTLEQYNNSKSFTVSKLTQPQEEIRLTNLYTLTNYTYCVVSTSSGTHHNHTCLTICLPKPPSPP 406

  Fly   709 DTTVNQTALVPPV------------VLDPLQQDLERERERERERELERDLDHEAVA-------KT 754
            ....:.:.....:            ||..:...|.:.|.:|.:.:       :|||       ||
Mouse   407 GPVPSPSTATHYIMTILGCLFGMVLVLGAVYYCLRKRRRQEEKHK-------KAVAAAAGSLKKT 464

  Fly   755 EYETVEYIPN--------LVQPP-VGSDALTPPP--SKANALEEDSESVHSNSVHAEYPHAAQS- 807
            ..| ::|.|.        |.|.| :|.:|:|..|  ..|.:..|..:.|.|    :|.|.|.:.
Mouse   465 IIE-LKYGPEIEAPGLAPLTQGPLLGPEAVTRIPYLPAATSDVEQYKLVES----SETPKATKGN 524

  Fly   808 -LQIPEEPPEE 817
             :::....|:|
Mouse   525 YIEVRTGEPQE 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	34/108 (31%)
		leucine-rich repeat	65..86	CDD:275380
		leucine-rich repeat	87..110	CDD:275380
		leucine-rich repeat	111..134	CDD:275380
		leucine-rich repeat	135..158	CDD:275380
		leucine-rich repeat	159..180	CDD:275380
		leucine-rich repeat	181..203	CDD:275380
		leucine-rich repeat	204..226	CDD:275380
		leucine-rich repeat	227..249	CDD:275380
		leucine-rich repeat	250..272	CDD:275380
		leucine-rich repeat	273..296	CDD:275380
		leucine-rich repeat	297..315	CDD:275380
		leucine-rich repeat	320..335	CDD:275378
		leucine-rich repeat	344..366	CDD:275380
		leucine-rich repeat	367..391	CDD:275380	8/22 (36%)
		leucine-rich repeat	392..415	CDD:275380	8/22 (36%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		leucine-rich repeat	440..462	CDD:275380	5/22 (23%)
		leucine-rich repeat	463..483	CDD:275380	4/19 (21%)
Elfn1	NP_780731.1	LRR	40..>190	CDD:443914	37/135 (27%)
		LRR 1	61..82		8/19 (42%)
		leucine-rich repeat	65..85	CDD:275378	7/19 (37%)
		LRR_8	85..144	CDD:404697	19/58 (33%)
		LRR 2	85..106		8/20 (40%)
		leucine-rich repeat	86..109	CDD:275378	8/22 (36%)
		LRR 3	109..130		6/20 (30%)
		leucine-rich repeat	110..133	CDD:275378	7/22 (32%)
		LRR 4	133..154		5/20 (25%)
		leucine-rich repeat	134..157	CDD:275378	5/22 (23%)
		LRR 5	157..178		4/20 (20%)
		leucine-rich repeat	158..171	CDD:275378	3/12 (25%)
		LRRCT	190..>228	CDD:214507	9/37 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..293		11/68 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	627..674
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	697..731