Protein Alignment ltl and Lingo1

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: XP_006511149.1
• Gene: Lingo1 / 235402
• MGIID: 1915522
• Length: 647
• Species: Mus musculus
• Alignment Length: 417
• Identity: 97/417 - (23%)
• Similarity: 171/417 - (41%)
• Gaps: 112/417 - (26%)

  Fly   138 LDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPKSLLILHLGRNQLESLNGSLHDLH 202
            ||:|:.:|:.:.|::|.....:..|.|..||::.::.|:|
Mouse   103 LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAF------------------------- 142

  Fly   203 NLESLFINANNITSLDDELPDGGQLRLLMAHNNRLERLPANM-AGMHSLETVHIHCNQL-RSFDR 265
                     ||:.:          ||.|...:|||:.:|..: .|:.:|..:.|..|:: ...|.
Mouse   143 ---------NNLFN----------LRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDY 188

  Fly   266 VLRNAVNLSEVMADNNELEYLAQDEFASCSKVETLQMGCNHIKSLNSSLLP------ILKLKNAN 324
            :.::..||..:...:|:|.|::...|:..:.:|.|.:...::.|:.:..|.      :|:|::.|
Mouse   189 MFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLN 253

  Fly   325 FSFNDIEEFSMAELHGLRSLKTLQLSS-NRIQRLLPDPRGVQELMLVNLDLDNNRIDSLN----- 383
              .|.|.::|...|:   .||.|::|. ..:..:.|:       .|..|:|.:..|...|
Mouse   254 --INAIRDYSFKRLY---RLKVLEISHWPYLDTMTPN-------CLYGLNLTSLSITHCNLTAVP 306

  Fly   384 -GALAGLGNLRILNLAGNRLEHLQVGDFDGMIRLDILDLTGNQLAELKPLEMTLLPSLKILKVAY 447
             .|:..|..||.|||:.|.:..::......::||..:.|.|.|||.::|..
Mouse   307 YLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVVEPYA-------------- 357

  Fly   448 NNITKLEQDFKGLPVLCQANLTNNQISTISSELVTNTRCKNHNVPGKLE-IHLDDNPIMCDVGLN 511
                     |:||..|...|::.||::|:.....       |:| |.|| :.||.||:.||
Mouse   358 ---------FRGLNYLRVLNVSGNQLTTLEESAF-------HSV-GNLETLILDSNPLACD---- 401

  Fly   512 ELCRLMAVQEARIRGRSQCFENDQEVC 538
              |||:.|...|.|..   |...|..|
Mouse   402 --CRLLWVFRRRWRLN---FNRQQPTC 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	76/352 (22%)
		leucine-rich repeat	65..86	CDD:275380
		leucine-rich repeat	87..110	CDD:275380
		leucine-rich repeat	111..134	CDD:275380
		leucine-rich repeat	135..158	CDD:275380	6/19 (32%)
		leucine-rich repeat	159..180	CDD:275380	6/20 (30%)
		leucine-rich repeat	181..203	CDD:275380	0/21 (0%)
		leucine-rich repeat	204..226	CDD:275380	2/21 (10%)
		leucine-rich repeat	227..249	CDD:275380	8/22 (36%)
		leucine-rich repeat	250..272	CDD:275380	4/22 (18%)
		leucine-rich repeat	273..296	CDD:275380	5/22 (23%)
		leucine-rich repeat	297..315	CDD:275380	3/17 (18%)
		leucine-rich repeat	320..335	CDD:275378	4/14 (29%)
		leucine-rich repeat	344..366	CDD:275380	5/22 (23%)
		leucine-rich repeat	367..391	CDD:275380	7/29 (24%)
		leucine-rich repeat	392..415	CDD:275380	6/22 (27%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		leucine-rich repeat	440..462	CDD:275380	3/21 (14%)
		leucine-rich repeat	463..483	CDD:275380	5/19 (26%)
Lingo1	XP_006511149.1	LRR	98..>398	CDD:443914	85/381 (22%)
		leucine-rich repeat	100..123	CDD:275380	6/19 (32%)
		leucine-rich repeat	124..147	CDD:275380	8/56 (14%)
		leucine-rich repeat	148..171	CDD:275380	8/22 (36%)
		leucine-rich repeat	172..219	CDD:275380	10/46 (22%)
		leucine-rich repeat	220..243	CDD:275380	4/22 (18%)
		leucine-rich repeat	244..291	CDD:275380	13/58 (22%)
		leucine-rich repeat	292..315	CDD:275380	5/22 (23%)
		leucine-rich repeat	316..339	CDD:275380	6/22 (27%)
		leucine-rich repeat	340..363	CDD:275380	10/45 (22%)
		leucine-rich repeat	364..384	CDD:275380	5/26 (19%)
		PCC	368..>448	CDD:188093	24/73 (33%)
		IgI_Lingo-1	450..541	CDD:409561
		Ig strand A	450..453	CDD:409561
		Ig strand A'	458..462	CDD:409561
		Ig strand B	468..477	CDD:409561
		Ig strand C	482..487	CDD:409561
		Ig strand C'	490..492	CDD:409561
		Ig strand D	501..504	CDD:409561
		Ig strand E	507..514	CDD:409561
		Ig strand F	520..528	CDD:409561
		Ig strand G	531..541	CDD:409561