Protein Alignment ltl and Chadl

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: XP_006520805.1
• Gene: Chadl / 214685
• MGIID: 3036284
• Length: 759
• Species: Mus musculus
• Alignment Length: 718
• Identity: 158/718 - (22%)
• Similarity: 243/718 - (33%)
• Gaps: 232/718 - (32%)

  Fly     1 MTSLVYTVFHLASLQCSVRPEISPCTCETGKAWNHVELSCEKLESFNAVVDSLANKLNADTNIDL 65
            |..|....:|:|:.:|       |.||....:..||....:.|......:..|..:|:...|| |
Mouse    28 MVLLQSPAWHVAAQRC-------PQTCVCDNSRRHVTCRHQNLTEVPNTIPELTQRLDLQGNI-L 84

  Fly    66 KITHSQLDDLEMRSFTDMNFNLYKLRMQWNSLKSLPEVPFRGLSNVTYLSIGDNDLDEIPKHALS 130
            |:       |...:|.|:. :|..|.::...::.:.|..||||..:..|::..|.|..:|:.||.
Mouse    85 KV-------LPAAAFQDLP-HLTHLDLRNCQVEMVAEGAFRGLGRLLLLNLASNRLSTLPQEALD 141

  Fly   131 HMPSLLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSF------------------ 177
            .:.||..|::....:..::...|..:..:|.|.|..|.:..|...:|
Mouse   142 GLGSLRRLELEGNMLEELRPGTFGALGSLTTLNLAHNALVYLPAMAFQGLLRTRWLQLSHNALSV 206

  Fly   178 --PKSL--------LILHLGRNQLESLNG-SLHDLHNLESLFINANNITSLDDE----LP----- 222
              |::|        |.||  .|:|::|.| :|....:|..|.:..|.:|...:|    ||
Mouse   207 LAPEALAGLPALRRLSLH--HNELQALPGAALSQARSLARLELGHNPLTYTGEEDGLALPGLREL 269

  Fly   223 --DGGQLRLL----MAHNNRLERL-----------PANMAGMHSLETVHIHCNQL---------- 260
              |.|.|:.|    .||..||..|           |..:.|  .|..:.:..|.|
Mouse   270 ALDHGSLQALGPRAFAHCPRLHTLDLRGNQLTTLPPLQVPG--QLRRLRLQGNPLWCACHARPLL 332

  Fly   261 --------RSFDRVLRNAVNL-SEVM------------------ADNNELE-------------- 284
                    || |...|....| .|.:                  .|.:|.|
Mouse   333 EWLVRARVRS-DGACRGPRRLRGEALDTLRPSDLRCPGDAAAGDGDGDEDEDRPAGPRAPPLRSP 396

  Fly   285 ---------------YLAQDEFASC-------------SKVETLQMGCNHIKSLNSSLLPIL--- 318
                           .:|:...::|             :..:.|.:..||..|:..:..|.|
Mouse   397 HGEAAWATPCPPACACVAETRHSTCDGRGLQAVPRGFPNDTQLLDLRRNHFPSVPRAAFPGLRHL 461

  Fly   319 ----------------------KLKNANFSFNDIEEFSMAELHGLRSLKTLQLSSNRIQRL---- 357
                                  :|.....|.|.:...|.|.|.|..:|..|.|..||..|:
Mouse   462 VSLHLQHCGVAELEPGALAGLDRLLYLYLSHNQLSGLSAAALEGAPNLGYLYLEHNRFLRIPGTA 526

  Fly   358 ---LPDPRGVQELMLVNLDLDNNRIDSL-NGALAGLGNLRILNLAGNRLEHLQVGDFDGMIRLDI 418
               ||        .||:|.|.:|.:|.| .|.|||...||.|.|:||.:..:..|.......|:.
Mouse   527 LRALP--------TLVSLHLQDNAVDRLAPGDLAGARALRCLYLSGNHITQVSPGALGPARELEK 583

  Fly   419 LDLTGNQLAELKPLEMTLLPSLKILKVAYN----------------------NITKLEQ----DF 457
            |.|..|:|.|:....:..||:||.|:::.|                      |.:.|||    .|
Mouse   584 LHLDRNRLREVPTGALEGLPALKELQLSGNPLRALPDGAFQPVGRSLQQLFLNSSDLEQISPRAF 648

  Fly   458 KGL-PVLCQANLTNNQISTISSELVTNTRCKNHNVPGKLEIHLDDNPIMCDVGLNELCRLMAVQE 521
            .|| ..|....|..||:.::.:.|         .:.|...:.|..||..||..|..|.|.:....
Mouse   649 SGLGKGLRSLYLHKNQLQSLPAPL---------GLSGLELVDLSGNPFHCDCQLLPLHRWLTGLN 704

  Fly   522 ARI 524
            .|:
Mouse   705 LRV 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	132/604 (22%)
		leucine-rich repeat	65..86	CDD:275380	5/20 (25%)
		leucine-rich repeat	87..110	CDD:275380	7/22 (32%)
		leucine-rich repeat	111..134	CDD:275380	6/22 (27%)
		leucine-rich repeat	135..158	CDD:275380	3/22 (14%)
		leucine-rich repeat	159..180	CDD:275380	7/40 (18%)
		leucine-rich repeat	181..203	CDD:275380	9/30 (30%)
		leucine-rich repeat	204..226	CDD:275380	8/32 (25%)
		leucine-rich repeat	227..249	CDD:275380	9/36 (25%)
		leucine-rich repeat	250..272	CDD:275380	7/39 (18%)
		leucine-rich repeat	273..296	CDD:275380	7/83 (8%)
		leucine-rich repeat	297..315	CDD:275380	4/17 (24%)
		leucine-rich repeat	320..335	CDD:275378	3/14 (21%)
		leucine-rich repeat	344..366	CDD:275380	8/28 (29%)
		leucine-rich repeat	367..391	CDD:275380	11/24 (46%)
		leucine-rich repeat	392..415	CDD:275380	7/22 (32%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		leucine-rich repeat	440..462	CDD:275380	11/48 (23%)
		leucine-rich repeat	463..483	CDD:275380	5/19 (26%)
Chadl	XP_006520805.1	LRRNT	43..75	CDD:214470	8/38 (21%)
		leucine-rich repeat	54..72	CDD:275380	3/17 (18%)
		LRR	67..>322	CDD:443914	62/267 (23%)
		leucine-rich repeat	74..97	CDD:275380	8/31 (26%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		leucine-rich repeat	122..145	CDD:275380	6/22 (27%)
		leucine-rich repeat	146..169	CDD:275380	3/22 (14%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	2/22 (9%)
		leucine-rich repeat	218..241	CDD:275380	8/24 (33%)
		leucine-rich repeat	242..265	CDD:275380	6/22 (27%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	312..351	CDD:275380	7/39 (18%)
		LRRNT	405..439	CDD:214470	2/33 (6%)
		leucine-rich repeat	437..460	CDD:275380	6/22 (27%)
		LRR	<455..>687	CDD:443914	62/248 (25%)
		leucine-rich repeat	461..484	CDD:275380	0/22 (0%)
		leucine-rich repeat	485..508	CDD:275380	7/22 (32%)
		leucine-rich repeat	509..532	CDD:275380	8/30 (27%)
		leucine-rich repeat	533..556	CDD:275380	11/22 (50%)
		leucine-rich repeat	557..580	CDD:275380	7/22 (32%)
		leucine-rich repeat	581..604	CDD:275380	7/22 (32%)
		leucine-rich repeat	605..629	CDD:275380	4/23 (17%)
		leucine-rich repeat	630..653	CDD:275380	7/22 (32%)
		leucine-rich repeat	655..677	CDD:275380	5/30 (17%)
		LRRCT	685..733	CDD:214507	8/23 (35%)