Protein Alignment ltl and Igfals

DIOPT Version :9

• Sequence 1: NP_001261524.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_001351825.1
• Gene: Igfals / 16005
• MGIID: 107973
• Length: 638
• Species: Mus musculus
• Alignment Length: 603
• Identity: 159/603 - (26%)
• Similarity: 252/603 - (41%)
• Gaps: 93/603 - (15%)

  Fly    15 QCSVRPEISPCTCETGKAWNHVELSCEKLESFNAVVDSL----------ANKLNAD--------T 61
            ||.|     .|||......:.:.:.|.. .:...:.||:          .|.|::.        :
Mouse    75 QCPV-----TCTCSYDDYTDELSVFCSS-RNLTQLPDSIPVSTRALWLDGNNLSSIPSAAFQNLS 133

  Fly    62 NID-LKITHSQLDDLEMRSFTDMNFNLYKLRMQWNSLKSLPEVPFRGLSNVTYLSIGDNDLDEIP 125
            ::| |.:..|.|..||.::...:. |||.|.::.|.|:||....||...::..||:|:|.|..:.
Mouse   134 SLDFLNLQGSWLRSLEPQALLGLQ-NLYHLHLERNLLRSLAAGLFRHTPSLASLSLGNNLLGRLE 197

  Fly   126 KHALSHMPSLLTLDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPKSLLI------- 183
            :.....:..|..|::|...:..:....|:|:..:..|:|..|.:|.|.     .:||.
Mouse   198 EGLFRGLSHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQ-----PALLCGLGELRE 257

  Fly   184 LHLGRNQLESL--NGSLHDLHNLESLFINANNITSLDDELPDGGQ-LRLLMAHNNR----LERLP 241
            |.|.||.|.|:  |..:| |..|:.|:::.|.||::......|.: ||.|...:||    ||...
Mouse   258 LDLSRNALRSVKANVFIH-LPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRVAGLLEDTF 321

  Fly   242 ANMAGMHSLETVHIHCNQLRSFDRVLRNAVNLSEVMADNNELEYLAQDEFASCSKVETLQMGCNH 306
            ..:.|:|.|...|.....||  .|..::...|.|:...:|.:..|.:..|....::|.|.:..|.
Mouse   322 PGLLGLHVLRLAHNAITSLR--PRTFKDLHFLEELQLGHNRIRQLGEKTFEGLGQLEVLTLNDNQ 384

  Fly   307 IKSLN-SSLLPILKLKNANFSFNDIEEFSMAELHGLRSLKTLQLSSNRIQRL-LPDPRGVQELML 369
            |..:. .:...:..:...|.|.|.:.........||..|.:|.|..:.:.|: |....|:..|.
Mouse   385 IHEVKVGAFFGLFNVAVMNLSGNCLRSLPEHVFQGLGRLHSLHLEHSCLGRIRLHTFAGLSGLR- 448

  Fly   370 VNLDLDNNRIDSL-NGALAGLGNLRILNLAGNRLEHLQVGDFDGMIRLDILDLTGNQLAELK--- 430
             .|.|.:|.|.|: ..:||||..|..|:|..|:|.||....|.|:.:|:.|.|:.|||..|.
Mouse   449 -RLFLRDNSISSIEEQSLAGLSELLELDLTANQLTHLPRQLFQGLGQLEYLLLSNNQLTMLSEDV 512

  Fly   431 --PLEMTLLPSLKILKVAYNNI-TKLEQDFKGLPVLCQANLTNNQISTISSELVTNTRCKNHNVP 492
              ||:....     |.:::|.: |..|..|..|..|...||.||.:.|...:            |
Mouse   513 LGPLQRAFW-----LDLSHNRLETPAEGLFSSLGRLRYLNLRNNSLQTFVPQ------------P 560

  Fly   493 GKLEIHLDDNPIMCDVGLNELCRLMAVQEARIRGR---SQCFEND-QEVCTVLPMLYNVNL---- 549
            |...:.||.||..|...|..| |..|:|...:..|   :.|..:| |.|.|     || |:
Mouse   561 GLERLWLDANPWDCSCPLKAL-RDFALQNPGVVPRFVQTVCEGDDCQPVYT-----YN-NITCAG 618

  Fly   550 PIMVTNLKLTGREVPKPM 567
            |..|:.|.|  |::.:.:
Mouse   619 PANVSGLDL--RDISETL 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380	5/20 (25%)
		LRR_8	86..145	CDD:290566	18/58 (31%)
		leucine-rich repeat	87..110	CDD:275380	9/22 (41%)
		leucine-rich repeat	111..134	CDD:275380	5/22 (23%)
		leucine-rich repeat	135..158	CDD:275380	5/22 (23%)
		LRR_8	158..214	CDD:290566	19/64 (30%)
		leucine-rich repeat	159..180	CDD:275380	5/20 (25%)
		leucine-rich repeat	181..203	CDD:275380	11/30 (37%)
		leucine-rich repeat	204..226	CDD:275380	6/21 (29%)
		LRR_RI	226..451	CDD:238064	64/238 (27%)
		leucine-rich repeat	227..249	CDD:275380	8/25 (32%)
		leucine-rich repeat	250..272	CDD:275380	5/21 (24%)
		leucine-rich repeat	273..296	CDD:275380	5/22 (23%)
		leucine-rich repeat	297..315	CDD:275380	4/18 (22%)
		LRR_8	319..402	CDD:290566	25/84 (30%)
		leucine-rich repeat	320..335	CDD:275378	3/14 (21%)
		leucine-rich repeat	344..366	CDD:275380	6/22 (27%)
		leucine-rich repeat	367..391	CDD:275380	10/24 (42%)
		LRR_8	369..426	CDD:290566	22/57 (39%)
		leucine-rich repeat	392..415	CDD:275380	9/22 (41%)
		leucine-rich repeat	416..439	CDD:275380	9/27 (33%)
		LRR_8	438..>479	CDD:290566	12/41 (29%)
		leucine-rich repeat	440..462	CDD:275380	6/22 (27%)
		leucine-rich repeat	463..483	CDD:275380	6/19 (32%)
Igfals	NP_001351825.1	LRRNT	75..113	CDD:214470	9/43 (21%)
		leucine-rich repeat	92..110	CDD:275380	3/18 (17%)
		PLN00113	96..>558	CDD:331614	126/478 (26%)
		leucine-rich repeat	114..134	CDD:275380	2/19 (11%)
		leucine-rich repeat	135..158	CDD:275380	6/23 (26%)
		leucine-rich repeat	159..182	CDD:275380	9/22 (41%)
		leucine-rich repeat	183..206	CDD:275380	5/22 (23%)
		leucine-rich repeat	207..230	CDD:275380	5/22 (23%)
		leucine-rich repeat	231..254	CDD:275380	7/27 (26%)
		leucine-rich repeat	255..278	CDD:275380	9/23 (39%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	6/24 (25%)
		leucine-rich repeat	351..374	CDD:275380	5/22 (23%)
		leucine-rich repeat	375..396	CDD:275380	4/20 (20%)
		leucine-rich repeat	423..446	CDD:275380	6/22 (27%)
		leucine-rich repeat	447..470	CDD:275380	10/24 (42%)
		leucine-rich repeat	471..494	CDD:275380	9/22 (41%)
		leucine-rich repeat	495..516	CDD:275380	7/20 (35%)
		leucine-rich repeat	519..542	CDD:275380	6/27 (22%)
		leucine-rich repeat	543..561	CDD:275380	6/29 (21%)
		TPKR_C2	570..613	CDD:326558	16/49 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910