DRSC/TRiP Functional Genomics Resources

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Protein Alignment ltl and LINGO2

DIOPT Version :10

Sequence 1:NP_729265.1 Gene:ltl / 38845 FlyBaseID:FBgn0268063 Length:817 Species:Drosophila melanogaster
Sequence 2:NP_689783.1 Gene:LINGO2 / 158038 HGNCID:21207 Length:606 Species:Homo sapiens


Alignment Length:482 Identity:101/482 - (20%)
Similarity:186/482 - (38%) Gaps:142/482 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 LDIGRCKIRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPKSLLILHLGRNQLESLNGSLHDLH 202
            ||:.:.::::|..|:|.....:..:.|..|||..::.|:|                     ::|.
Human    62 LDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAF---------------------NNLF 105

  Fly   203 NLESLFINANNITSLDDELPDGGQLRLLMAHNNRLERLPANM-AGMHSLETVHIHCNQL-RSFDR 265
            ||.||.:.                       .|||:.:|..: .|:.:|..:.|..|:: ...|.
Human   106 NLRSLRLK-----------------------GNRLKLVPLGVFTGLSNLTKLDISENKIVILLDY 147

  Fly   266 VLRNAVNLSEVMADNNELEYLAQDEFASCSKVETLQM-GCN----------HIKSLNSSLLPILK 319
            :.::..||..:...:|:|.|::...|:....:|.|.: .||          |::||.|     |.
Human   148 MFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLIS-----LH 207

  Fly   320 LKNANFSFNDIEEFSMAELHGLRSLKTLQLSSNRIQRLLPDPRGVQELMLVNLDLDNNRIDSLNG 384
            ||:.|  .|::..::...|.   .||.|::....:..::| ...:..|.|.:|.:.|..:.::..
Human   208 LKHLN--INNMPVYAFKRLF---HLKHLEIDYWPLLDMMP-ANSLYGLNLTSLSVTNTNLSTVPF 266

  Fly   385 -ALAGLGNLRILNLAGNRLEHLQVGDFDGMIRLDILDLTGNQLAELKPLEMTLLPSLKILKVAYN 448
             |...|..|..|||:.|.:..::.|.|..:|||..|.:.|.||..::|                 
Human   267 LAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEP----------------- 314

  Fly   449 NITKLEQDFKGLPVLCQANLTNNQISTISSELVTNTRCKNHNVPGKLEI-HLDDNPIMCDVGLNE 512
                  ..|:||..|...|::.|.:.|:...:.::        |..||: .:::||:.||     
Human   315 ------HSFQGLRFLRVLNVSQNLLETLEENVFSS--------PRALEVLSINNNPLACD----- 360

  Fly   513 LCRLMAVQEARIRGRSQCFENDQEVC----------------TVLPMLYNVNLPIMVTNLKL--- 558
             |||:.:.:   |..:..|...|.:|                |.|...:....| .:...||   
Human   361 -CRLLWILQ---RQPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTCKKP-KIREKKLQHL 420

  Fly   559 ---TGREV---------PKPMVRVIVP 573
               .|:.|         |:|::..:.|
Human   421 LVDEGQTVQLECSADGDPQPVISWVTP 447

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ltlNP_729265.1 LRR 65..476 CDD:443914 76/351 (22%)
leucine-rich repeat 65..86 CDD:275380
leucine-rich repeat 87..110 CDD:275380
leucine-rich repeat 111..134 CDD:275380
leucine-rich repeat 135..158 CDD:275380 5/19 (26%)
leucine-rich repeat 159..180 CDD:275380 6/20 (30%)
leucine-rich repeat 181..203 CDD:275380 1/21 (5%)
leucine-rich repeat 204..226 CDD:275380 3/21 (14%)
leucine-rich repeat 227..249 CDD:275380 5/22 (23%)
leucine-rich repeat 250..272 CDD:275380 4/22 (18%)
leucine-rich repeat 273..296 CDD:275380 5/22 (23%)
leucine-rich repeat 297..315 CDD:275380 8/28 (29%)
leucine-rich repeat 320..335 CDD:275378 4/14 (29%)
leucine-rich repeat 344..366 CDD:275380 4/21 (19%)
leucine-rich repeat 367..391 CDD:275380 6/24 (25%)
leucine-rich repeat 392..415 CDD:275380 7/22 (32%)
leucine-rich repeat 416..439 CDD:275380 6/22 (27%)
leucine-rich repeat 440..462 CDD:275380 3/21 (14%)
leucine-rich repeat 463..483 CDD:275380 4/19 (21%)
LINGO2NP_689783.1 LRRNT 27..60 CDD:214470
leucine-rich repeat 39..57 CDD:275380
LRR 48..>340 CDD:443914 77/355 (22%)
LRR 1 58..79 5/16 (31%)
leucine-rich repeat 59..82 CDD:275380 5/19 (26%)
LRR 2 82..103 6/41 (15%)
leucine-rich repeat 83..106 CDD:275380 7/43 (16%)
LRR 3 106..127 8/43 (19%)
leucine-rich repeat 107..130 CDD:275380 8/45 (18%)
LRR 4 130..151 4/20 (20%)
leucine-rich repeat 131..154 CDD:275380 4/22 (18%)
LRR 5 154..175 6/20 (30%)
leucine-rich repeat 155..178 CDD:275380 5/22 (23%)
LRR 6 178..199 4/20 (20%)
leucine-rich repeat 179..202 CDD:275380 5/22 (23%)
LRR 7 202..223 8/27 (30%)
leucine-rich repeat 203..250 CDD:275380 12/57 (21%)
LRR 8 226..247 4/21 (19%)
LRR 9 250..271 4/20 (20%)
leucine-rich repeat 251..274 CDD:275380 5/22 (23%)
LRR 10 274..295 7/20 (35%)
leucine-rich repeat 275..298 CDD:275380 7/22 (32%)
LRR 11 298..319 8/43 (19%)
leucine-rich repeat 299..322 CDD:275380 9/45 (20%)
LRR 12 322..343 4/20 (20%)
leucine-rich repeat 323..343 CDD:275380 4/19 (21%)
LRRCT 355..408 CDD:214507 13/61 (21%)
Ig 411..500 CDD:472250 7/37 (19%)
Ig strand B 428..432 CDD:409353 1/3 (33%)
Ig strand C 441..445 CDD:409353 0/3 (0%)
Ig strand E 466..470 CDD:409353
Ig strand F 480..485 CDD:409353
Ig strand G 493..496 CDD:409353
Blue background indicates that the domain is not in the aligned region.

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