Protein Alignment ltl and atk

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: XP_320584.5
• Gene: atk / 1280722
• VectorBaseID: AGAMI1_013064
• Length: 1622
• Species: Anopheles gambiae
• Alignment Length: 1124
• Identity: 239/1124 - (21%)
• Similarity: 390/1124 - (34%)
• Gaps: 385/1124 - (34%)

  Fly     1 MTSLVYTVFH------LASLQCS----VRPEISPCTCETGKAWNHVELS-CEKLESFNAVVDSLA 54
            :|.:.:..||      |..|:.:    |.||.......:|....|::.: ..::|...:::|:|.
Mosquito   338 ITEIFHGAFHRTPSLKLVHLENNYLRRVHPESFLQASGSGVEMMHLQQNEIGRVEELRSLLDALP 402

  Fly    55 ---------NKLNA---------DTNIDLKITHSQLDDLEMRSFTDMNFNLYKLRMQWNSLKSLP 101
                     |||.|         .|...|.:..:::..:|..:|..|. .|.:||:|.|||....
Mosquito   403 MLRFLDLSHNKLEAIPFGALRGHGTLEQLYLNQNRIRMIERDAFMAMP-GLRELRLQNNSLHDQL 466

  Fly   102 EVPFRGLS-----NVTY-------------------LSIGDNDLDEIPKHALSHMPSLLTLDIGR 142
            .:||..|.     :::|                   |.|..|.|..|...|.:|.|.|.|::|..
Mosquito   467 PMPFWNLPGLKGIDISYNSFRRMDPNLLVGVPSLRRLDISGNTLSVIDAGAFTHTPMLETVNISF 531

  Fly   143 CKIRAVQQEDFR------------------------GIQRVT---NLI----------------- 163
            .::..:....||                        .::||.   |:|
Mosquito   532 NELSLIHSATFRDLNHMFELDAGNNKLQEFIPGLPVAVERVNLHGNMITQLPPPTTASQLWDLPN 596

  Fly   164 -----LVSNIITRLDRGSFPKS--LLILHLGRNQLESL-NGSLHDLHNLESLFINANNITSLDDE 220
                 :.:|.:|||.|..|..:  |.:|.|.||||:|: :|||..|..||.|.:..|.:.:|.:.
Mosquito   597 LRMLDISANQLTRLPRAVFKPTPQLRVLSLARNQLQSVDDGSLSGLSRLEILNLQDNRVLALHER 661

  Fly   221 -LPDGGQLRLLMAHNNRLERLPANMAGMHSLETVHIHCNQLRSFDRVLRNAVNLSEVMADNNELE 284
             ......||.|....||:|.|..|:...::|         |..||             |..|.:.
Mosquito   662 CFSPLENLRELNLQGNRIEVLVDNLLDSNAL---------LEQFD-------------ASRNSIV 704

  Fly   285 YLAQDEFASCSKVETLQMGCNHIKSLNSSLLPILKLKNANFSFNDIEEFSMAELHGLRSLKTLQL 349
            .::...|.:...::||.:..|.::.|..||..:.:|:..:.|||.:.|.|...|...|:|:.|::
Mosquito   705 EISPKAFRNSRSLQTLDLSSNQLRELPESLSGLAELRELDVSFNQLTELSPNVLVSWRNLEELKV 769

  Fly   350 SSNRIQRL-------LPDPRGVQELMLVNLDLDNNRIDSL-NGALAGLGNLRILNLAGNRLEHLQ 406
            |:|::.:|       ||        :|..|||.:|.:..| :|:|..|..|:.|.||.|:|..|:
Mosquito   770 SNNKVNQLHQGSLRNLP--------LLQYLDLSSNELTLLEHGSLRNLPELQELVLADNKLSELK 826

  Fly   407 VGDFDGM-----------------------------------------------IR-LDILDLTG 423
            ...|:.:                                               :| |::|||||
Mosquito   827 ERVFEDLPNLQAVHLQQNNLRYISPYSFFRSPSIVYLNLSANQFRSLDSVGLRSVRNLEVLDLTG 891

  Fly   424 NQLAELKPLEMTLLPSLKILKVAYNNITKLE-QDFKGLPVLCQANLTNNQISTISSELVTNTRCK 487
            |.:.::.|..:..|..|..||:..|.|..:: :.|..:|.|...::.|||:|.:...:..:.|.
Mosquito   892 NSIRKITPSPLRGLDWLVELKLDNNKICGIQGEPFATMPRLRVLSMRNNQMSRVPEPIFRSLRT- 955

  Fly   488 NHNVPGKLEIHLDDNPIMCDVGLNELCRLMAVQEAR-IRGRSQCFENDQEVCTVLPMLYNVNLPI 551
              |:   ..:.:|.||:.|...:  |..:..:||:| :....:|.:.        .||.::.|
Mosquito   956 --NI---AILDVDGNPLDCSCDM--LWYMAWLQESRSLYPGPRCRDG--------KMLLDMRL-- 1003

  Fly   552 MVTNLKLTGREVPK------PMVR----VIVPSLI------KANNEL----LPPLIATLGNP--- 593
            ..|:.:...|..|.      |:..    |.|.:|.      ..|.||    .||..|  |:|
Mosquito  1004 SRTDCQSGARTAPSGHQGDHPLTNDHGDVFVRALDYDECAGSENYELPPGPTPPFHA--GSPSPG 1066

  Fly   594 --------------VLISTDLVN------------------------------------------ 602
                          .|..|.|.|
Mosquito  1067 DSDYFYDQYVDYPNALNDTRLANGQRFNNTTPFAQDPQQDRRNYTTNFVDFNNNKFNQFQRPPGG 1131

  Fly   603 -PVISPLPP-------PLLLATTTPPPPLPL---------------------------------P 626
             |.:.||||       |... ...|.|.|.:                                 |
Mosquito  1132 APPLPPLPPGGQDSGSPFTF-FGLPIPSLNIGKMFGGAAGRNANNRASGGSRAKGRVQVYKQGEP 1195

  Fly   627 VESEV-----EKNESTTANPVPTNYTQETTTTTSTTTT--TTTTETSSQVAP-IEI----ITTTA 679
            .:|.:     .|.|||.....||:...:....|:....  ....:||.:..| :::    .|...
Mosquito  1196 EQSTIYRADGGKTESTVTLKAPTDPLDKNAGATNENNLFYRPFFQTSYRQPPSVDVQQGGFTPML 1260

  Fly   680 PTTTTTSTTTPKPNETLPVIVELQDPNPP---DTTVNQTALVPPVVLDP---LQQDLERERERER 738
            |  ......||..:.||.||.:.....||   .|..|:..   |:|.:|   |||:
Mosquito  1261 P--GAVGGFTPITDPTLKVINQNYTHEPPGKWPTEFNERV---PLVTEPTRYLQQN--------- 1311

  Fly   739 ERELERDLDHEAVAKTEYETVEYIPNLV--QPPVGSDALTPP---PSKANALEEDSESVHSNSVH 798
                    ..||..|..:.:..|..:.:  ..|...|.:..|   |.:.:..|:.|.:..|||..
Mosquito  1312 --------KFEATIKPSHNSAPYFVDGITHHIPGKQDVVASPPMVPKRPDVSEKLSSAGGSNSTG 1368

  Fly   799 AEYPHAAQSLQIPEEPPEE 817
            :..||:    ::.||..||
Mosquito  1369 SGVPHS----EMEEEDEEE 1383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	130/544 (24%)
		leucine-rich repeat	65..86	CDD:275380	4/20 (20%)
		leucine-rich repeat	87..110	CDD:275380	10/27 (37%)
		leucine-rich repeat	111..134	CDD:275380	8/41 (20%)
		leucine-rich repeat	135..158	CDD:275380	5/46 (11%)
		leucine-rich repeat	159..180	CDD:275380	9/45 (20%)
		leucine-rich repeat	181..203	CDD:275380	12/22 (55%)
		leucine-rich repeat	204..226	CDD:275380	5/22 (23%)
		leucine-rich repeat	227..249	CDD:275380	8/21 (38%)
		leucine-rich repeat	250..272	CDD:275380	4/21 (19%)
		leucine-rich repeat	273..296	CDD:275380	3/22 (14%)
		leucine-rich repeat	297..315	CDD:275380	5/17 (29%)
		leucine-rich repeat	320..335	CDD:275378	5/14 (36%)
		leucine-rich repeat	344..366	CDD:275380	7/28 (25%)
		leucine-rich repeat	367..391	CDD:275380	9/24 (38%)
		leucine-rich repeat	392..415	CDD:275380	8/69 (12%)
		leucine-rich repeat	416..439	CDD:275380	9/22 (41%)
		leucine-rich repeat	440..462	CDD:275380	6/22 (27%)
		leucine-rich repeat	463..483	CDD:275380	5/19 (26%)
atk	XP_320584.5	None