Protein Alignment ltl and ELFN2

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_443138.2
• Gene: ELFN2 / 114794
• HGNCID: 29396
• Length: 820
• Species: Homo sapiens
• Alignment Length: 655
• Identity: 130/655 - (19%)
• Similarity: 215/655 - (32%)
• Gaps: 222/655 - (33%)

  Fly   223 DGGQLRLLMAHNNR--LERLPANMAGMHSLETVH---IHCNQLRSFDRVLRNAV----NLSEVMA 278
            |.|.:.|.:...|:  .|.:|     .|...|||   ::.|:|::   ||.:::    ||:::..
Human    30 DKGYVWLAICSQNQPPYETIP-----QHINSTVHDLRLNENKLKA---VLYSSLNRFGNLTDLNL 86

  Fly   279 DNNELEYLAQDEFASCSKVETLQMGCNHIKSLNSSLLPILKLKNANFSFNDIEEFSMAELHGLRS 343
            ..||:.|:....|...|.::.||:|.|.:.:|...:                       |.|:..
Human    87 TKNEISYIEDGAFLGQSSLQVLQLGYNKLSNLTEGM-----------------------LRGMSR 128

  Fly   344 LKTLQLSSNRIQRLLPDPRGVQEL-MLVNLDLDNNRIDSLNGA-LAGLGNLRILNLAGNRLEHLQ 406
            |:.|.:..|.|:  :..|....|. .|:::||.:||:..|:|| .|.|.:|.:..||||...
Human   129 LQFLFVQHNLIE--VVTPTAFSECPSLISIDLSSNRLSRLDGATFASLASLMVCELAGNPFN--- 188

  Fly   407 VGDFDGMIRLDILDLTGNQLAELKPLEMTLLPSLKILKVAYNNITK--------LEQDFKGLPVL 463
                                     .|..|...|..| |.:||:||        ..::|.|.|:
Human   189 -------------------------CECDLFGFLAWL-VVFNNVTKNYDRLQCESPREFAGYPL- 226

  Fly   464 CQANLTNNQISTISSELVTNTRCKNHNVPGKLEIHLDDNPIMCDVGLNELCRLMAVQEARIRGRS 528
                |......::::..|...:|:|.::|.:...|  ..|...|.             .|....:
Human   227 ----LVPRPYHSLNAITVLQAKCRNGSLPARPVSH--PTPYSTDA-------------QREPDEN 272

  Fly   529 QCFENDQEVCTVLPMLYNVNLPIMVTNLKLTGREVPKPMVRVIVPS-------LIKANNELLPPL 586
            ..| |..|:.:|.|...:.........:||.........:.||:|.       |::.||.....
Human   273 SGF-NPDEILSVEPPASSTTDASAGPAIKLHHVTFTSATLVVIIPHPYSKMYILVQYNNSYFSD- 335

  Fly   587 IATLGNPVLISTDLVNPVISPLPPPLLLATTTPPPPLPLPVESEVEKNESTTANPVPTNYTQETT 651
            :.||.|                                        |.|..|.:.:.. :|:.|.
Human   336 VMTLKN----------------------------------------KKEIVTLDKLRA-HTEYTF 359

  Fly   652 TTTSTTTT-----TTTTETSSQVAPIEIITTTAPTTTTTS------------------------- 686
            ..||...:     |..|.|:....|.::    ||:|:||:
Human   360 CVTSLRNSRRFNHTCLTFTTRDPVPGDL----APSTSTTTHYIMTILGCLFGMVIVLGAVYYCLR 420

  Fly   687 -----TTTPKPNETLPVIVELQ-----DP-----------NPPDTTVNQTALVPPVVLDPLQQDL 730
                 ....|.......|:|::     |.           .||...|::.|.:|.::.:.|
Human   421 KRRMQEEKQKSVNVKKTILEMRYGADVDAGSIVHAAQKLGEPPVLPVSRMASIPSMIGEKL---- 481

  Fly   731 ERERERERERELERDLDHEAVAKTEYETVEYIPNLVQPPVGSDALTPPPSKANALEEDSESVHSN 795
                  ...:.||..||...|| |:...:|     |:...|.|.|..|......||....|....
Human   482 ------PTAKGLEAGLDTPKVA-TKGNYIE-----VRTGAGGDGLARPEDDLPDLENGQGSAAEI 534

  Fly   796 SVHAE 800
            |..|:
Human   535 STIAK 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	62/271 (23%)
		leucine-rich repeat	65..86	CDD:275380
		leucine-rich repeat	87..110	CDD:275380
		leucine-rich repeat	111..134	CDD:275380
		leucine-rich repeat	135..158	CDD:275380
		leucine-rich repeat	159..180	CDD:275380
		leucine-rich repeat	181..203	CDD:275380
		leucine-rich repeat	204..226	CDD:275380	1/2 (50%)
		leucine-rich repeat	227..249	CDD:275380	4/23 (17%)
		leucine-rich repeat	250..272	CDD:275380	7/28 (25%)
		leucine-rich repeat	273..296	CDD:275380	5/22 (23%)
		leucine-rich repeat	297..315	CDD:275380	5/17 (29%)
		leucine-rich repeat	320..335	CDD:275378	0/14 (0%)
		leucine-rich repeat	344..366	CDD:275380	5/21 (24%)
		leucine-rich repeat	367..391	CDD:275380	10/25 (40%)
		leucine-rich repeat	392..415	CDD:275380	5/22 (23%)
		leucine-rich repeat	416..439	CDD:275380	2/22 (9%)
		leucine-rich repeat	440..462	CDD:275380	9/29 (31%)
		leucine-rich repeat	463..483	CDD:275380	2/19 (11%)
ELFN2	NP_443138.2	LRR 1	56..77		7/23 (30%)
		LRR	<60..>205	CDD:443914	44/201 (22%)
		leucine-rich repeat	60..80	CDD:275378	4/22 (18%)
		LRR 2	80..101		6/20 (30%)
		leucine-rich repeat	81..104	CDD:275378	5/22 (23%)
		LRR 3	104..125		6/43 (14%)
		leucine-rich repeat	105..128	CDD:275378	7/45 (16%)
		LRR 4	128..149		5/22 (23%)
		leucine-rich repeat	129..152	CDD:275378	6/24 (25%)
		LRR 5	152..173		8/20 (40%)
		leucine-rich repeat	153..166	CDD:275378	5/12 (42%)
		leucine-rich repeat	177..189	CDD:275378	5/39 (13%)
		leucine-rich repeat	200..226	CDD:275380	8/26 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..294		10/59 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	508..527		6/18 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	589..612
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..677