Protein Alignment ltl and si:dkey-182i3.11

DIOPT Version :9

• Sequence 1: NP_001261524.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: XP_021322095.1
• Gene: si:dkey-182i3.11 / 100334238
• ZFINID: ZDB-GENE-121214-258
• Length: 710
• Species: Danio rerio
• Alignment Length: 673
• Identity: 166/673 - (24%)
• Similarity: 269/673 - (39%)
• Gaps: 140/673 - (20%)

  Fly    25 CTC---ETGKAWN--------------HVELSCEKL-----ESFN--AVVDSLANKLNADTNIDL 65
            |:|   :....||              |...:..|:     |:|:  .|:|...|..|...|.:.
Zfish    59 CSCVDVDIVTCWNTNLLEFPPLPNGTKHFYATRNKIQALPNETFHELRVLDLTKNVFNLSLNTNW 123

  Fly    66 K----ITHSQLDDLEMRSFTDMNF----NLYKLRMQWNSLKSLPEVPFRGLSN------------ 110
            :    :||..|....:|:.|...|    ||..|.:..|::||||::...||.|
Zfish   124 QSVRGLTHLHLGGNRLRALTPRQFEGLLNLQVLDLSNNAIKSLPQMFLYGLINLQTLNLNINQIL 188

  Fly   111 ------------VTYLSIGDNDLDEIPKHALSHMPSLLTLDIGRCKIRAVQQEDFRG-------- 155
                        :|.|.:.||.:|.|..:...:...|..|.:.:.|:::|....|:|
Zfish   189 SLSYGVLEGPLALTDLQLRDNMIDMIEMNVFENCTYLAKLYLSKNKLKSVGNGSFKGATGLNHLD 253

  Fly   156 ----------------IQRVTNLILVSNIITRLDRGSFPKSLLILH--LGRNQLESL-NGSLHDL 201
                            ...:|:|.|..|.||.:....|.:.|.:.|  |..|.|.|: |||...|
Zfish   254 LGLNGLAGIPTIVLQETSNLTSLYLQKNDITSIPDNVFSEILSLKHLDLSYNGLVSISNGSFRSL 318

  Fly   202 HNLESLFINANNITSLDDEL-PDGGQLRLLMAHNNRLERLPANMAGMHSLETVHIHCNQLRSFDR 265
            ..|..|.::.|.:.:|...: .|.|:|..|..::|:|..||.||
Zfish   319 SQLVYLDLSFNQLQTLTQHVFEDLGKLENLNLYHNKLTSLPNNM--------------------- 362

  Fly   266 VLRNAVNLSEVMADNNELEYLAQDEFASCSKVETLQMGCNHIKSLNSSLLPILK-LKNANFSFND 329
             .:|...|.|:..|:|.:..:..|.|...|.::.||:..|||..|:|.....|: ||..:.|.||
Zfish   363 -FKNLTMLKELQLDSNNISVIPPDLFHPLSALKDLQLDNNHISKLHSHTFKKLRQLKQLDISSND 426

  Fly   330 IEEFSMAELHGLRSLKTLQLSSNRIQRLLPDPRGVQEL-MLVNLDLDNNRIDSL-NGALAGLGNL 392
            :.:......|  ::||.|.|.:|.|..:  .....:.| .|.:|.|.:|.:..| ...|..|..|
Zfish   427 LTKIPNHLFH--KNLKELNLENNHISFI--SKFSFKNLHRLQSLKLSHNNLSKLYRELLTNLTRL 487

  Fly   393 RILNLAGNRLEHLQVGDFDGMIRLDILDLTGNQLAELKPLEMTLLPSLKILKVAYNNITKLEQD- 456
            |.|.|..|::|.:.||.|.|:..|.:|||:.|::..:.|.....|.:||.|.:::|.:..|.:|
Zfish   488 RELLLNENQIETIPVGFFKGLENLRVLDLSNNKMHFILPDAFNDLSALKDLDLSFNFLHNLPEDI 552

  Fly   457 FKGLPVLCQANLTNNQISTISSELVTNTRCKNHNVPGKLEIHLDDNPIMCDVGLNELCRLMAVQE 521
            |..|..|.:.:|.||::..:.|.|.:       .:.|..|:|||.|.|            ..:..
Zfish   553 FASLRNLTKLHLQNNKLRYLPSRLFS-------ALVGLEELHLDRNYI------------QRIHP 598

  Fly   522 ARIRGRSQCFENDQEVCTVLPMLYNVNLPI-MVTNLKLTGREVPKPMVRVIVPSLIKANNELL-- 583
            .:..|..:..|.|.:...:..|.....:|: .:..:.|.|.......|.::..|....||..|
Zfish   599 TQFEGLVKLHELDMKSNQLRSMEDGTLMPLRKLKRIHLDGNPWDCSTVVILYISQWFNNNTQLVK 663

  Fly   584 -PPLIAT---LGNPVLISTDLVN 602
             .|:.::   |.||.|..:.|:|
Zfish   664 TTPMCSSGQNLSNPALFPSSLLN 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380	6/28 (21%)
		LRR_8	86..145	CDD:290566	19/82 (23%)
		leucine-rich repeat	87..110	CDD:275380	9/22 (41%)
		leucine-rich repeat	111..134	CDD:275380	6/22 (27%)
		leucine-rich repeat	135..158	CDD:275380	6/46 (13%)
		LRR_8	158..214	CDD:290566	20/58 (34%)
		leucine-rich repeat	159..180	CDD:275380	7/20 (35%)
		leucine-rich repeat	181..203	CDD:275380	10/24 (42%)
		leucine-rich repeat	204..226	CDD:275380	5/22 (23%)
		LRR_RI	226..451	CDD:238064	65/227 (29%)
		leucine-rich repeat	227..249	CDD:275380	8/21 (38%)
		leucine-rich repeat	250..272	CDD:275380	1/21 (5%)
		leucine-rich repeat	273..296	CDD:275380	6/22 (27%)
		leucine-rich repeat	297..315	CDD:275380	7/17 (41%)
		LRR_8	319..402	CDD:290566	25/85 (29%)
		leucine-rich repeat	320..335	CDD:275378	5/14 (36%)
		leucine-rich repeat	344..366	CDD:275380	6/21 (29%)
		leucine-rich repeat	367..391	CDD:275380	8/25 (32%)
		LRR_8	369..426	CDD:290566	22/57 (39%)
		leucine-rich repeat	392..415	CDD:275380	10/22 (45%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		LRR_8	438..>479	CDD:290566	12/41 (29%)
		leucine-rich repeat	440..462	CDD:275380	8/22 (36%)
		leucine-rich repeat	463..483	CDD:275380	6/19 (32%)
si:dkey-182i3.11	XP_021322095.1	PLN00113	97..>617	CDD:331614	144/564 (26%)
		leucine-rich repeat	129..152	CDD:275380	6/22 (27%)
		leucine-rich repeat	153..176	CDD:275380	9/22 (41%)
		leucine-rich repeat	177..200	CDD:275380	0/22 (0%)
		leucine-rich repeat	201..224	CDD:275380	6/22 (27%)
		leucine-rich repeat	225..248	CDD:275380	6/22 (27%)
		leucine-rich repeat	249..272	CDD:275380	0/22 (0%)
		leucine-rich repeat	273..296	CDD:275380	7/22 (32%)
		leucine-rich repeat	297..320	CDD:275380	9/22 (41%)
		leucine-rich repeat	321..344	CDD:275380	5/22 (23%)
		leucine-rich repeat	345..368	CDD:275380	9/44 (20%)
		leucine-rich repeat	369..392	CDD:275380	6/22 (27%)
		leucine-rich repeat	393..438	CDD:275380	14/46 (30%)
		leucine-rich repeat	417..436	CDD:275380	5/18 (28%)
		leucine-rich repeat	439..462	CDD:275380	7/24 (29%)
		leucine-rich repeat	463..486	CDD:275380	7/22 (32%)
		leucine-rich repeat	487..510	CDD:275380	10/22 (45%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		leucine-rich repeat	535..558	CDD:275380	8/22 (36%)
		leucine-rich repeat	559..582	CDD:275380	6/29 (21%)
		leucine-rich repeat	583..606	CDD:275380	7/34 (21%)
		leucine-rich repeat	607..628	CDD:275380	3/20 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910