Protein Alignment ltl and elfn1b

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: XP_001920383.1
• Gene: elfn1b / 100144401
• ZFINID: ZDB-GENE-080327-21
• Length: 814
• Species: Danio rerio
• Alignment Length: 812
• Identity: 166/812 - (20%)
• Similarity: 288/812 - (35%)
• Gaps: 256/812 - (31%)

  Fly    83 MNFNLYKLRMQWNSLKSLPEVPFRGLS---NVTYLSIGDNDLDEIPKHALSHMPSLLTLDIGRCK 144
            :|..:..||:..|.::|   :.|..||   |:|||::..||:..|...|.|...:|..|.||..|
Zfish    75 INSTIVDLRLNENKIRS---IHFSSLSRFGNLTYLNLTKNDISYIEDGAFSAQFNLQVLQIGFNK 136

  Fly   145 IRAVQQEDFRGIQRVTNLILVSNIITRLDRGSFPKSLLI--LHLGRNQLESLNG-SLHDLHNLES 206
            :|.:.:...||:.|:..|.|.:|:|..:...:|.:...|  :.|..|:::.|:| :...|..|.:
Zfish   137 MRNLTEGMLRGLGRLQYLYLQANLIETVTANAFWECPAIENIDLSMNRIQQLDGATFRGLSKLTT 201

  Fly   207 LFINANNITSLDDELPDGGQLRLLMAHNNRL-ERL----PANMAGMHSLETVHIHCNQLRSFDRV 266
            ..:.||..:...:.|   |.||.|:|..||. ||:    ||..:|...|       :|.....|
Zfish   202 CELYANPFSCSCELL---GFLRWLVAFPNRTSERMACDTPAGFSGYSLL-------SQNPRMPR- 255

  Fly   267 LRNAVN-LSEVMADNNELEYL--AQD--------EFASCS---------KVETLQMGCNHIKSLN 311
            .|||.: ||.|..|:|...||  :.|        :.:.|.         ..||:.:....   |:
Zfish   256 YRNAFHALSSVCTDDNVTPYLHGSPDGGIPTRLPDLSPCGLDDCSSGTFPEETISISPTF---LD 317

  Fly   312 SSLLPILKLKNANFSFNDIEEFSMAELHGLRSLKTLQLSSNRIQRLLPDP-RGVQELMLVNLDLD 375
            |...||:|||               |:....::.|:|         :|:| |.:..|:|.|
Zfish   318 SDARPIMKLK---------------EVTHTSAVITIQ---------IPNPFRKMYILVLYN---- 354

  Fly   376 NNRIDSLNGALAGLGNLRILNLAGNRLEHLQVGDFDGMIRLDILDLTGNQLAELKPLEMTLLPSL 440
                   |.....:.||:                              :|..|::      |.:|
Zfish   355 -------NSFFTDIQNLK------------------------------SQREEIE------LQNL 376

  Fly   441 KILKVAYNNITKLEQDFKGLPVLCQANLTNNQISTISSELVTNTRCKNHNVPGKLEIHLDDNPIM 505
            |    ::.|.|           .|.|::.|:
Zfish   377 K----SHTNYT-----------YCVASIRNS---------------------------------- 392

  Fly   506 CDVGLNELCRLMAVQEARIRGRSQCFENDQE----VCTVLPMLYN--VNLPIMVTNL-KLTGREV 563
              :..|..|..::.....::.|   ..||..    :.|:|..|:.  :.|.::|..| |...::.
Zfish   393 --LRFNHTCLTISTGPRTLQER---VVNDSTATHYIMTILGCLFGMLIVLGVVVHCLRKRKKQDE 452

  Fly   564 PKPMVRVIVPSLIKANNELLPPLIATLGNPVLISTDLVNPVISPLPPPLLLA---TTTPPPPLPL 625
            ||.      ..|.|....|:         .:...|:|....||.|....:|:   |....|.||.
Zfish   453 PKS------KKLEKMKRNLI---------EMKYGTELEQGTISQLSQKQILSAGETVQRMPYLPA 502

  Fly   626 PVESEVEKNESTTANPVPT--NYTQ-----------ETTTTTSTTTTTTTTETSSQVAPIEII-- 675
            ..:::..|.:..:..|..|  ||.:           |.:...|.|:..:..|.|:....::.:
Zfish   503 ASDTDQYKMQEISGTPKTTKGNYMEVRSEQPERSIRECSVPPSETSQGSVAEISTIAKEVDKVNQ 567

  Fly   676 ------------TTTAPTTTTTSTTTPKPNETLPVIVELQDPNPPDTTVNQTALVPPVVLDPLQQ 728
                        :|:..|..:.:.:|.:|.  |.:|.|    :||    .::..:.||.......
Zfish   568 IINNCIDALKSDSTSFQTAKSGAVSTAEPQ--LVLISE----HPP----GKSGFLSPVYKGGYHH 622

  Fly   729 DLERERERERERE-----------LERDLDHEAVAKTEYETVEYIPNLVQPPVGSDALTPPPSKA 782
            .|:|....:..::           ..|....|...::|.:.:|    ...|...|..:|..|:.|
Zfish   623 PLQRHHSMDAPQKRASTSSSGSLRSPRSFRSEGAYRSESKYIE----KASPQDESGIITVTPAAA 683

  Fly   783 NALEEDSESVHSNSVHA-EYP---HAAQSLQI 810
             .|..::|.:...|.|. .||   |..:|:::
Zfish   684 -ILRAEAERIRQYSEHRHSYPGPHHIEESIEV 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	99/424 (23%)
		leucine-rich repeat	65..86	CDD:275380	1/2 (50%)
		leucine-rich repeat	87..110	CDD:275380	7/25 (28%)
		leucine-rich repeat	111..134	CDD:275380	8/22 (36%)
		leucine-rich repeat	135..158	CDD:275380	8/22 (36%)
		leucine-rich repeat	159..180	CDD:275380	5/20 (25%)
		leucine-rich repeat	181..203	CDD:275380	6/24 (25%)
		leucine-rich repeat	204..226	CDD:275380	4/21 (19%)
		leucine-rich repeat	227..249	CDD:275380	11/26 (42%)
		leucine-rich repeat	250..272	CDD:275380	6/21 (29%)
		leucine-rich repeat	273..296	CDD:275380	9/41 (22%)
		leucine-rich repeat	297..315	CDD:275380	4/17 (24%)
		leucine-rich repeat	320..335	CDD:275378	2/14 (14%)
		leucine-rich repeat	344..366	CDD:275380	5/22 (23%)
		leucine-rich repeat	367..391	CDD:275380	4/23 (17%)
		leucine-rich repeat	392..415	CDD:275380	1/22 (5%)
		leucine-rich repeat	416..439	CDD:275380	3/22 (14%)
		leucine-rich repeat	440..462	CDD:275380	4/21 (19%)
		leucine-rich repeat	463..483	CDD:275380	3/19 (16%)
elfn1b	XP_001920383.1	LRR	<68..>210	CDD:443914	40/137 (29%)
		leucine-rich repeat	82..102	CDD:275378	7/22 (32%)
		leucine-rich repeat	103..126	CDD:275378	8/22 (36%)
		leucine-rich repeat	127..150	CDD:275378	8/22 (36%)
		leucine-rich repeat	151..174	CDD:275378	5/22 (23%)
		leucine-rich repeat	175..188	CDD:275378	3/12 (25%)
		PCC	179..>247	CDD:188093	21/70 (30%)