Protein Alignment ltl and vasnb

DIOPT Version :10

• Sequence 1: NP_729265.1
• Gene: ltl / 38845
• FlyBaseID: FBgn0268063
• Length: 817
• Species: Drosophila melanogaster
• Sequence 2: NP_001104232.1
• Gene: vasnb / 100004428
• ZFINID: ZDB-GENE-110714-1
• Length: 668
• Species: Danio rerio
• Alignment Length: 767
• Identity: 160/767 - (20%)
• Similarity: 241/767 - (31%)
• Gaps: 294/767 - (38%)

  Fly    86 NLYKLRMQWNSLKSLPEVPFRGLSNVTYLSIGDNDLDEIPKHALSHMPSLLTLDIGRCKIRAVQQ 150
            |||..:   |.::||.:..|..|.::..|.:..|.|.|:|.|....:.||..||:...:|..:.:
Zfish    58 NLYVFK---NGIESLSQEDFVHLGSLEMLDLSQNQLTELPDHVFEPLSSLNNLDLSANQIVHISK 119

  Fly   151 EDFRGIQRVTNLILVSNIITRLDRGSFPKSLLILHLGRNQLESLNGSLHDLHNLESLFINANNIT 215
            ..|.|::.:..|.|.||:|..:...:|                  ..||:|  ||
Zfish   120 YSFAGLELLERLYLYSNLIESIHPAAF------------------DGLHEL--LE---------- 154

  Fly   216 SLDDELPDGGQLRLLMAHNNRLERLPANMAGMHSLETVHIHCNQLRSFDRVLRNAVNLSEVMADN 280
                          |....|:|:.|||       |:..|:....|| |:.:         .....
Zfish   155 --------------LKLQGNKLKILPA-------LKMPHLLLLDLR-FNSI---------PSPGP 188

  Fly   281 NELEYLAQDEFASCSKVETLQMGCNHIKSLNSSLLPILKLKNANFSFNDIEEFSMAELHGLRSLK 345
            |:|:         ..|:|:|::|...:.:||..||.         ||.::.|
Zfish   189 NDLQ---------TPKLESLKLGGLGLSTLNEELLG---------SFKNLHE------------- 222

  Fly   346 TLQLSSNRIQRLLPDPRGVQELMLVNLDLDNNRIDSLNGALAGLGNLRILNLAGNRLEHLQVGDF 410
                                      ||:.||::.:....|.....|..|.||||.:..|...||
Zfish   223 --------------------------LDISNNQLTAFPVVLREAKGLVSLVLAGNPMGPLNWEDF 261

  Fly   411 DGMIRLDILDLTGNQLAELKPLEMTLLPSLKILKVAYNNITKLEQDFKGLPVLCQANLT------ 469
            :.:..|..||::...|..|......|||.||.|.||.|            |..|..||.
Zfish   262 EKLTELHELDISNLSLQGLPETLAQLLPHLKRLTVAEN------------PFNCLCNLAWFPSWL 314

  Fly   470 -NNQISTISSELVTNTRCKNHNVP---GKLEIHLDDNPIMCDVGLNELCRLMAVQEARIRGRSQC 530
             ..||....:|   .|||  |..|   ||:...|......|.:......|::.
Zfish   315 RTKQIQLGRTE---ETRC--HFPPLNSGKVLERLGHREFGCPITTTITTRMVK------------ 362

  Fly   531 FENDQEVCTVLPMLYNVNLPIMVTNLKLTGREVPKPMVRVIVPSLIKANNELLPPLIATLGNPVL 595
                   .|.:|                     |.|...  |||...|   :|||  ....||
Zfish   363 -------STAVP---------------------PAPFTS--VPSTTHA---ILPP--KPSNNP-- 390

  Fly   596 ISTDLVNPVISPLPPPLLLATTTPPPPLPLPVESEVEKNESTTANP------VPTNYT------- 647
             |||:               ...|.||.|           ||:.:|      .|:|..
Zfish   391 -STDI---------------DYDPAPPTP-----------STSIDPDLRSTFCPSNICLNGGTCW 428

  Fly   648 ------QETTTTTSTTTTTTTTETSSQVAPIEIITTTAPTTTTTSTTTPKPNETLPVIVELQDPN 706
                  .|......|:.|....|....:.|.||  |:.|.......|:...:..|...:::: ||
Zfish   429 LDNEGHVECICVPGTSGTYCEKEEDPLLFPTEI--TSEPEIIAKKVTSSSIHLDLRRYIDMR-PN 490

  Fly   707 PPDTTVNQTALVPPVVLDPLQQDLERERERERERELERDLDHEAVAKTEYETVEYIPNLVQPPVG 771
                       :..|.|  ..::|..:.:|.::..:....|            |||...:||...
Zfish   491 -----------IRGVKL--TYRNLSGQDKRPKQLSVPHYYD------------EYILRGLQPNST 530

  Fly   772 SDALTPPPSKA---NALEEDSESVHSNSVHAEYPHAAQSLQIP------EEP 814
            ......|..:|   |.:..::::|              |||||      |:|
Zfish   531 YSVCASPLGEAGNVNRVCTEAQTV--------------SLQIPPTGARLEDP 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ltl	NP_729265.1	LRR	65..476	CDD:443914	90/396 (23%)
		leucine-rich repeat	65..86	CDD:275380	160/767 (21%)
		leucine-rich repeat	87..110	CDD:275380	7/22 (32%)
		leucine-rich repeat	111..134	CDD:275380	6/22 (27%)
		leucine-rich repeat	135..158	CDD:275380	6/22 (27%)
		leucine-rich repeat	159..180	CDD:275380	6/20 (30%)
		leucine-rich repeat	181..203	CDD:275380	3/21 (14%)
		leucine-rich repeat	204..226	CDD:275380	2/21 (10%)
		leucine-rich repeat	227..249	CDD:275380	6/21 (29%)
		leucine-rich repeat	250..272	CDD:275380	5/21 (24%)
		leucine-rich repeat	273..296	CDD:275380	2/22 (9%)
		leucine-rich repeat	297..315	CDD:275380	5/17 (29%)
		leucine-rich repeat	320..335	CDD:275378	3/14 (21%)
		leucine-rich repeat	344..366	CDD:275380	0/21 (0%)
		leucine-rich repeat	367..391	CDD:275380	5/23 (22%)
		leucine-rich repeat	392..415	CDD:275380	9/22 (41%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		leucine-rich repeat	440..462	CDD:275380	6/21 (29%)
		leucine-rich repeat	463..483	CDD:275380	6/26 (23%)
vasnb	NP_001104232.1	leucine-rich repeat	56..79	CDD:275380	8/23 (35%)
		LRR	<72..358	CDD:443914	94/420 (22%)
		leucine-rich repeat	80..103	CDD:275380	6/22 (27%)
		leucine-rich repeat	104..151	CDD:275380	13/64 (20%)
		leucine-rich repeat	152..172	CDD:275380	10/52 (19%)
		leucine-rich repeat	173..195	CDD:275380	5/40 (13%)
		leucine-rich repeat	196..219	CDD:275380	9/31 (29%)
		leucine-rich repeat	220..242	CDD:275380	6/60 (10%)
		leucine-rich repeat	243..266	CDD:275380	9/22 (41%)
		leucine-rich repeat	267..290	CDD:275380	7/22 (32%)
		EGF_CA	417..449	CDD:238011	5/31 (16%)
		FN3	463..534	CDD:473895	15/96 (16%)