DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8539 and Agbl2

DIOPT Version :9

Sequence 1:	NP_001261520.1	Gene:	CG8539 / 38842	FlyBaseID:	FBgn0035791	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_848870.2	Gene:	Agbl2 / 271813	MGIID:	2443254	Length:	862	Species:	Mus musculus

Alignment Length:	424	Identity:	73/424 - (17%)
Similarity:	143/424 - (33%)	Gaps:	162/424 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SYDGIMQYLDELALS--HSNRVTLKDVARTYENRALKMAIITNGDGRP----GKRVIFLDAALHS 98
            :|..:..||..:|.:  .|....|:.:.|:.....:.:..|||....|    .|:.:.|.|.:|.
Mouse   362 TYTDLQCYLLSVANNPIQSQFCKLRALCRSLAGNTVYLLTITNPSRTPQEAAAKKAVVLSARVHP 426

  Fly    99 RE----WMTPAAALLTIHKLVVEFAENSDLLTD-YDWHIMPLANPDGYEYSRNTERYWRNTRTPN 158
            .|    |:     :......::..:.::.||.| :.:.::|:.||||....        |.|.
Mouse   427 GESNSSWI-----MNGFLDFILSNSPDAQLLRDIFVFKVIPMLNPDGVIVG--------NYRC-- 476

  Fly   159 GGNCFGTNLNRNFAVDWNVGFPELKD--PCDENYAGSSPFSEVEARTVRDIMHGLVESKRAVMYL 221
              :..|.:|||::..       .|||  ||              ....::::..|:|.:..::|.
Mouse   477 --SLAGRDLNRHYKT-------VLKDSFPC--------------IWYTKNMIKRLLEEREVLLYC 518

  Fly   222 SLHTANR--SVFYPWVYDTDPVSNQKEH----------------DEIG----RFVADRILQSTGT 264
            ..|..:|  ::|   :|...  ||.::|                |:..    .|...:..:.||.
Mouse   519 DFHGHSRKNNIF---LYGCH--SNNRKHWLHERVFPLMLSKNAPDKFSFDSCNFKVQKCKEGTGR 578

  Fly   265 FIKTWQYA---KYA--GTFGGTSMDYALLAGFPLSFVFEMSGTGRD-------------HV---- 307
            .: .|:..   .|.  .||||:::                 |:.||             ||
Mouse   579 VV-MWRMGIINSYTMESTFGGSTL-----------------GSKRDTHFTIEDLKSLGYHVCDTL 625

  Fly   308 -------EYKFFPPARDIRHLAEE-----------------SWTGI--------KAFAEKTIEKY 340
                   :.|:....::::.|.::                 :|:.|        .:.::.::...
Mouse   626 LDFCDPDQTKYTQCLQELKELLQQEINKKLNNFGQDMDLEGNWSDIPLSDIESSTSGSDSSLSDG 690

  Fly   341 PPSRVISY------------NPMVKLAENAATRN 362
            ||.|:::.            ||..|..:....||
Mouse   691 PPIRLLNIVADEPNQKTVLKNPKKKRLQTRKQRN 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8539	NP_001261520.1	M14_CP_A-B_like	38..335	CDD:199844	65/383 (17%)
Agbl2	NP_848870.2	Pepdidase_M14_N	231..358	CDD:375499
		M14_AGBL2-3_like	379..629	CDD:349478	57/310 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	669..692		1/22 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..728		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	750..836
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900