DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d8 and ERG5

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_013728.1	Gene:	ERG5 / 855029	SGDID:	S000004617	Length:	538	Species:	Saccharomyces cerevisiae

Alignment Length:	542	Identity:	130/542 - (23%)
Similarity:	223/542 - (41%)	Gaps:	108/542 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLVVLLFGAGWIIHLGQADRRRKVANLPGPICP--PLIGAMQLMLRLNPKTFIKVGREYVLKF-- 65
            |:.:||.   |    .|...:.|..::.||...  |:||  ..:..|:||.     .||..|:
Yeast    52 LICILLV---W----DQVAYQIKKGSIAGPKFKFWPIIG--PFLESLDPKF-----EEYKAKWAS 102

  Fly    66 GHLQRVWIFNRLLIMSGDAELNEQLLSSQEHL---VKHPVYKVLG--QWLGNGLLLSDGKVWHQR 125
            |.|..|.||::.::::...:|..::|.|.:.:   |.....|:|.  .|     :..|||.....
Yeast   103 GPLSCVSIFHKFVVIASTRDLARKILQSSKFVKPCVVDVAVKILRPCNW-----VFLDGKAHTDY 162

  Fly   126 RKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNTF-------DVYRSICAAALDIIAETA 183
            ||.:...|....|.|::...:|..:..:.:..:.:..|.:       ::...:||.:|:.....
Yeast   163 RKSLNGLFTKQALAQYLPSLEQIMDKYMDKFVRLSKENNYEPQVFFHEMREILCALSLNSFCGN- 226

  Fly   184 MGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELL-FTLTHPHLKWRQTQLIRTMQEFTI 247
                 |...::....|:.....||.|           ||: |.:..|:.|   |...:...:..:
Yeast   227 -----YITEDQVRKIADDYYLVTAAL-----------ELVNFPIIIPYTK---TWYGKKTADMAM 272

  Fly   248 KVIEKRRQALEDQQS-------------KLMDTA----DEDVGSKRRMALLDVLLMSTVDGRPLT 295
            |:.|...|..:|..:             |||..|    |:|               |.:..|..|
Yeast   273 KIFENCAQMAKDHIAAGGKPVCVMDAWCKLMHDAKNSNDDD---------------SRIYHREFT 322

  Fly   296 NDEIREEVDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELK 360
            |.||.|.|.||:|...|.::|...:....::..|:|.||:.||.:.|...|.|..:::..:.::|
Yeast   323 NKEISEAVFTFLFASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNLDLIEKMK 387

  Fly   361 YMECVIKESLRMYPPVPIVGRKLQTDF----KYTHSVHGDGVIPAGSEIIIGIFGVHRQPETFPN 421
            |...||||:||..|||.:|...::.:|    .||        .|.|:.:|..::.....||.:.|
Yeast   388 YTNMVIKETLRYRPPVLMVPYVVKKNFPVSPNYT--------APKGAMLIPTLYPALHDPEVYEN 444

  Fly   422 PDEFIPERHENGSRVAPFK--MIPFSAGPRNCIGQKFAQLEMKMMLAKIVR----EYELLPMGQR 480
            ||||||||...||:.:..|  .:.|..||..|:||.:..:....:|.|...    .:.:.|:.::
Yeast   445 PDEFIPERWVEGSKASEAKKNWLVFGCGPHVCLGQTYVMITFAALLGKFALYTDFHHTVTPLSEK 509

  Fly   481 VECIVNIVLRSETGFQLGMRKR 502
            ::....|..:.:  ..|..:||
Yeast   510 IKVFATIFPKDD--LLLTFKKR 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	110/470 (23%)
ERG5	NP_013728.1	CYP61_CYP710	103..522	CDD:410703	110/468 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I1557
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	120	1.000	Inparanoid score	I1313
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto100215
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X23
TreeFam	0	0.000	Not matched by this tool.
	6	5.990