DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d8 and CYP86A4

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_171666.1	Gene:	CYP86A4 / 839347	AraportID:	AT1G01600	Length:	554	Species:	Arabidopsis thaliana

Alignment Length:	554	Identity:	135/554 - (24%)
Similarity:	229/554 - (41%)	Gaps:	104/554 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLVVLLFGAGWIIHLGQADRRRKVAN-LPGPICPPLIGAMQLMLRLNPKTFIKVGREYVLK---- 64
            |||.::.|. |:..       ::::. |.||...||:|::..::....:.     .|::.:
plant     8 LLVAIVTGY-WLWF-------KRISRWLKGPRVWPLLGSLPGLIEQRDRM-----HEWITENLRA 59

  Fly    65 FGHLQRVWIF--------NRLLIMSGDAELNEQLLSSQ-EHLVKHPVYK-VLGQWLGNGLLLSDG 119
            .|...:..||        ..|:.::.|.:..|.:|.:: ::..|.|.:: |....||.|:..|||
plant    60 CGGTYQTCIFAVPFLAKKQGLVTVTCDPKNLEHMLKTRFDNYPKGPTWQSVFHDLLGQGIFNSDG 124

  Fly   120 KVWHQRRKIITPTFHFSILEQFVEVFDQQS---NICVQRLAQKANGNTFDVYRSICAAALDIIAE 181
            ..|..:||.....|....|.|.:..:..:.   ..|......:.|....|:...|.....|.|..
plant   125 DTWLFQRKTAALEFTTRTLRQAMGRWVNRGIKLRFCPILATAQDNAEPVDLQDLILRLTFDNICG 189

  Fly   182 TAMG--TKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWR---------Q 235
            .|.|  |:..|.......:|.|.:..|.....||:.             |...|:         :
plant   190 LAFGKDTRTCAPGLPENGFASAFDRATEASLQRFII-------------PKFMWKLKKWLGLGLE 241

  Fly   236 TQLIRTM---QEFTIKVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTND 297
            ..|.|::   .|:...||..|:|.|..||        |....:|...||...:|...:.   .:|
plant   242 VSLSRSLGEIDEYLAAVINTRKQELMSQQ--------ESGTHQRHDDLLSRFMMKKTES---YSD 295

  Fly   298 EIREEVD-TFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVL----GTD-----RSRPVS 352
            ...:.|. .|:..|.||::.|||:....::.||.|:.|::.||..||    |||     ...|:.
plant   296 TFLQHVALNFILAGRDTSSVALSWFFWLITMHPTVEDKIVREICSVLIETRGTDDVASWTEEPLG 360

  Fly   353 IRDLGELKYMECVIKESLRMYPPVPIVGRKLQTDFKYTHSVHGDGV-IPAGSEIIIGIFGVHRQP 416
            ..::..|.|::..|.|:||:||.||...:.::.|     .|..||. :||||.:...|:...|..
plant   361 FDEIDRLVYLKAAISETLRLYPSVPEDSKHVEND-----DVLPDGTFVPAGSSVTYSIYAAGRMK 420

  Fly   417 ETFPNPD--EFIPERHENGSRVAP----------FKMIPFSAGPRNCIGQKFAQLEMKMMLAKIV 469
            .|: ..|  ||.|||.     ::|          ::.:.|:||||.|:|:..|.|:||.:.|.::
plant   421 STW-GEDCLEFNPERW-----ISPIDGKFINHDQYRFVAFNAGPRICLGKDLAYLQMKTIAAAVL 479

  Fly   470 REYELLPM-GQRVECIVNIVLRSETGFQLGMRKR 502
            ..:.|..: |.:||..:::.|..:.|..:.:.||
plant   480 LRHRLTVVPGHKVEQKMSLTLFMKNGLLVNLYKR 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	121/481 (25%)
CYP86A4	NP_171666.1	PLN03195	5..513	CDD:215627	133/552 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920