DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d8 and CYP86A8

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_182121.1	Gene:	CYP86A8 / 819205	AraportID:	AT2G45970	Length:	537	Species:	Arabidopsis thaliana

Alignment Length:	581	Identity:	133/581 - (22%)
Similarity:	224/581 - (38%)	Gaps:	164/581 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WIIHLGQADRRRKVANLPGPICPPLIGAMQLMLRLNPKTFIKVGREYVLKFGHLQRV--WIFNRL 77
            |:..:.:.        |.||...|::|::..::.                  :.:|:  ||.:.|
plant    19 WLTFISRC--------LKGPRVWPILGSLPGLIE------------------NCERMHDWISDNL 57

  Fly    78 LIMSGDAEL----------NEQLLS------SQEHLVKH--------PVYK-VLGQWLGNGLLLS 117
            ...||..:.          .:.|::      :.||::|:        |.:: |....||.|:..|
plant    58 RACSGTYQTCICAIPFLAKKQGLVTVTCDPRNLEHILKNRFDNYPKGPTWQAVFHDLLGQGIFNS 122

  Fly   118 DGKVWHQRRKIITPTFHFSILEQFV-----------------------EVFDQQ--------SNI 151
            ||..|..:||.....|....|.|.:                       |..|.|        .||
plant   123 DGDTWLFQRKTAALEFTTRTLRQAMARWVNRAIKLRFLPILENARLGSEPIDLQDLLLRLTFDNI 187

  Fly   152 CVQRLAQKANGNTFDVYRSICAAALDIIAETAMGTKIYAQANESTPYAEAVNECTALLSWRFMSV 216
            |         |.||......||..|.:                 ..:|.|.:..|.....||:.
plant   188 C---------GLTFGKDPRTCAPGLPV-----------------NTFAVAFDRATEASLQRFIL- 225

  Fly   217 YLQVELLFTLTHPHLKWRQTQLIRTMQEFTIKVIEKRRQALEDQQSKLMDTADEDVGSKRRMAL- 280
                        |.:.|:..:.:|...|.:   :.:....:::..|:::.|..|::.::.....
plant   226 ------------PEILWKFKRWLRLGLEVS---LTRSLVQVDNYLSEIITTRKEEMMTQHNNGKH 275

  Fly   281 LDVLLMSTVDGRPLTNDEIREEVD-TFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVL- 343
            .|.||...:..:...:||..:.|. .|:..|.||::.|||:....:::||.::.|:|.||..||
plant   276 HDDLLSRFIKKKESYSDETLQRVALNFILAGRDTSSVALSWFFWLITQHPAIEDKILREICTVLV 340

  Fly   344 ---GTD----RSRPVSIRDLGELKYMECVIKESLRMYPPVPIVGRKLQTDFKYTHSVHGDGV-IP 400
               |.|    ...|:|..:|..|.:::..:.|:||:||.||...::...|     .|..||. :|
plant   341 ETRGDDVALWTDEPLSCEELDRLVFLKAALSETLRLYPSVPEDSKRAVKD-----DVLPDGTFVP 400

  Fly   401 AGSEIIIGIFGVHRQPETFPNPD--EFIPER---HENGSRVA---PFKMIPFSAGPRNCIGQKFA 457
            |||.|...|:...|...|: ..|  ||.|||   ..:|.|..   |||.:.|:||||.|:|:..|
plant   401 AGSSITYSIYSAGRMKSTW-GEDCLEFKPERWISQSDGGRFINHDPFKFVAFNAGPRICLGKDLA 464

  Fly   458 QLEMKMMLAKIVREYEL-LPMGQRVE------------CIVNIVLRSETGFQLGMRKRKHN 505
            .|:||.:.:.::..:.| :..|.:||            .:||:..|..|.....:|:.|.|
plant   465 YLQMKSIASAVLLRHRLTVVTGHKVEQKMSLTLFMKYGLLVNVHERDLTAIAADLRECKSN 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	124/520 (24%)
CYP86A8	NP_182121.1	CYP86A	67..503	CDD:410687	114/483 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920