Protein Alignment Cyp4d8 and TBXAS1

DIOPT Version :9

• Sequence 1: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 131/532 - (24%)
• Similarity: 210/532 - (39%)
• Gaps: 132/532 - (24%)

  Fly    23 DRRRKVANLPGPICPPLIGAMQLMLRLNPKTFIKVGREYVLKFGH------------------LQ 69
            :.:.::..|.||:|...:|....::...|....:|..|....|.:                  ..
Human    65 ESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRD 129

  Fly    70 RVWIFNRLLIMS--GDAELNE-QLLSSQEHLVKHPVYKVLGQWLGNGLLLSDGKVWHQRRKIITP 131
            :.|...|..:||  ...:||| .||..||.:..|         :|       |:...||   |.|
Human   130 KRWEEVRGALMSAFSPEKLNELGLLIMQERIKGH---------MG-------GQQAPQR---IPP 175

  Fly   132 T-----------FHFSILE-QFVEVFDQQSNICVQRLAQKA-NGNTFDVYRSICAAALDIIAETA 183
            |           .|::.|. ..|.:..|..::.:..|.:.| :|:.||:.|..|....|::|..|
Human   176 TRLSKPSGIYVNLHYATLPFCMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVA 240

  Fly   184 MGTKIYAQANESTPYAEAVNECTALLSWRFMSVYL-QVELLFTLTHPHLKWRQTQLIRTMQEFTI 247
            .||.:.:......|:   |..|.     ||....: :..|:..|:.|.:   ...|.|.:.
Human   241 FGTPVDSWQAPEDPF---VKHCK-----RFFEFCIPRPILVLLLSFPSI---MVPLARILP---- 290

  Fly   248 KVIEKRRQALEDQQSKLMDTA----DEDVGSKRRMALLDVLL--------MSTVD---------- 290
               .|.|..|....:||:...    |:....:||...|.::|        |...|
Human   291 ---NKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSS 352

  Fly   291 ----------------GRPLTNDEIREEVDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEI 339
                            .||||.|||..:...|:..|::..|:.|||..:.|:.:|:.|.|:|.|
Human   353 TGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLRE- 416

  Fly   340 VQVLGTDRSRP--VSIRDLGELKYMECVIKESLRMYPPVPIVGRKLQTDFKYTHSVHGD-----G 397
            |.|.......|  .|:.:  .|.|::.||.|:||||||.          |::|.....|     .
Human   417 VDVFKEKHMAPEFCSLEE--GLPYLDMVIAETLRMYPPA----------FRFTREAAQDCEVLGQ 469

  Fly   398 VIPAGSEIIIGIFGVHRQPETFPNPDEFIPERH--ENGSRVAPFKMIPFSAGPRNCIGQKFAQLE 460
            .||||:.:.:.:..:|..||.:|:|:.|.|||.  |...:..||..:||.||||:|:|.:...||
Human   470 RIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLE 534

  Fly   461 MKMMLAKIVREY 472
            :|:.|..::.::
Human   535 VKLTLLHVLHKF 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	122/489 (25%)
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	131/532 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840