DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d8 and Cyp4a31

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_964002.2	Gene:	Cyp4a31 / 666168	MGIID:	3028580	Length:	509	Species:	Mus musculus

Alignment Length:	523	Identity:	158/523 - (30%)
Similarity:	258/523 - (49%)	Gaps:	90/523 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LIGAMQ------LMLRLNPKTFIKVGREYVLK-------------FGHLQRVWIFNRLLIMSGDA 84
            |.|.:|      |:|.|.....:.:.|:::||             |||.|          ..||.
Mouse    15 LSGFLQVASVFCLLLLLVKAVQVYLHRKWLLKALQQFPSPPFHWFFGHEQ----------FKGDQ 69

  Fly    85 ELNEQLLSSQEHL----------------VKHP----------------VYKVLGQWLGNGLLLS 117
            ||.| ::|..|:.                |..|                .|::|..|:|.||||.
Mouse    70 ELQE-IVSCIENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRSDPKANGAYRLLAPWIGYGLLLL 133

  Fly   118 DGKVWHQRRKIITPTFHFSILEQFVEVFDQQSNICV---QRLAQKANGNTFDVYRSICAAALDII 179
            :|:.|.|.||::||.||:.||:.:|:.......:.:   :|||  ...::.::::.|....||.:
Mouse   134 NGQSWFQHRKMLTPAFHYDILKTYVKNMADSIRLMLDKWERLA--GQDSSIEIFQHISLMTLDTV 196

  Fly   180 AETAMGTK--IYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTL-THPHLKWRQTQLIRT 241
            .:.|...|  :....|..| |.:|:.:...|:..|..:::.|.:.::.| ::..|..:..||
Mouse   197 MKCAFSHKGSVQVDGNYKT-YLQAIGDLNNLVHSRVRNMFHQNDTIYKLSSNGRLSNQACQL--- 257

  Fly   242 MQEFTIKVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTND-EIREEVDT 305
            ..:.|..||:.|:..|:|:...      |::..|||:..||:||.:.::.....:| ::|.||||
Mouse   258 AHDHTDGVIKMRKDQLQDEGEL------ENIKKKRRLDFLDILLFARMENEDSMSDKDLRAEVDT 316

  Fly   306 FMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESL 370
            ||.||||||.|.:|:..:.|:.|||.|.:..||:..:||...|  ::...|.::.|....|||:|
Mouse   317 FMIEGHDTTASGVSWIFYALATHPEHQQRCREEVQSLLGDGSS--ITWDHLDQIPYTTMCIKEAL 379

  Fly   371 RMYPPVPIVGRKLQTDFKYTHSVHGDGV-IPAGSEIIIGIFGVHRQPETFPNPDEFIPERHENGS 434
            |:|||||.:||:|.|...:.     ||. :|.|.::.:.|:|:|..|:.:|||:.|.|.|....|
Mouse   380 RLYPPVPSIGRELSTSVTFP-----DGCSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDS 439

  Fly   435 RVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLPMGQRVE-CIVNIVLRSETGFQLG 498
            .......:|||.|.|||||::||..|:|:::|..:..:||||...||. .:...||:|:.|..|.
Mouse   440 PRHSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMSLARFVLKSKNGIYLH 504

  Fly   499 MRK 501
            ::|
Mouse   505 LKK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	146/471 (31%)
Cyp4a31	NP_964002.2	p450	52..503	CDD:278495	147/480 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845122
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750