Protein Alignment Cyp4d8 and CYP4F12

DIOPT Version :10

• Sequence 1: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 401
• Identity: 141/401 - (35%)
• Similarity: 223/401 - (55%)
• Gaps: 19/401 - (4%)

  Fly   104 KVLGQWLGNGLLLSDGKVWHQRRKIITPTFHFSILEQFVEVFDQQSNICV---QRLAQKANGNTF 165
            :.|..|||.|:|||.|..|.:.|:::||.|||:||:.::.:|::.:||.:   |.||.:.: :..
Human   126 RFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGS-SRL 189

  Fly   166 DVYRSICAAALDIIAETAMGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPH 230
            |::..|....||.:.:.......:.|...| .|...:.|.:||:..|...:...::.|:.|:|..
Human   190 DMFEHISLMTLDSLQKCIFSFDSHCQERPS-EYIATILELSALVEKRSQHILQHMDFLYYLSHDG 253

  Fly   231 LKWRQTQLIRTMQEFTIKVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMS-TVDGRPL 294
            .::.:.  .|.:.:||..||.:||:.|..|.   :|...:|....:.:..:||||:| ..||:.|
Human   254 RRFHRA--CRLVHDFTDAVIRERRRTLPTQG---IDDFFKDKAKSKTLDFIDVLLLSKDEDGKAL 313

  Fly   295 TNDEIREEVDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGEL 359
            ::::||.|.|||||.|||||.|.||:.|:.|:||||.|.:..:|:.::|.....:.:...||.:|
Human   314 SDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQL 378

  Fly   360 KYMECVIKESLRMYPPVPIVGRKLQTDFKYTHSVHGDG-VIPAGSEIIIGIFGVHRQPETFPNPD 423
            .::...:|||||::||.|.:.|....|.     |..|| |||.|...:|.|.|||..|..:|:|:
Human   379 PFLTMCVKESLRLHPPAPFISRCCTQDI-----VLPDGRVIPKGITCLIDIIGVHHNPTVWPDPE 438

  Fly   424 EFIPERH--ENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLPMGQRVECIVN 486
            .:.|.|.  ||....:|...|||||||||||||.||..|||::||.::..:..||........:.
Human   439 VYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLE 503

  Fly   487 IVLRSETGFQL 497
            :::|:|.|..|
Human   504 LIMRAEGGLWL 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	140/399 (35%)
CYP4F12	NP_076433.3	CYP4F	74..515	CDD:410772	141/401 (35%)