DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d8 and zgc:123299

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	XP_021324190.1	Gene:	zgc:123299 / 641477	ZFINID:	ZDB-GENE-051120-33	Length:	501	Species:	Danio rerio

Alignment Length:	531	Identity:	140/531 - (26%)
Similarity:	247/531 - (46%)	Gaps:	83/531 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LFLLVVLLFGAG---------WIIHLGQADRRRKVANLPGPICPP----LIG---AMQLMLRLNP 51
            :|.:::.|..|.         ::.|:.|     |..::||   ||    |:|   ::...|..:.
Zfish     6 IFYIILYLLAAVFTAFFAYCLYVHHIHQ-----KYDHIPG---PPRDNFLLGHSPSLTKALYSDD 62

  Fly    52 KTFIKVGREYVLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHP-----VYKVLG-QWL 110
            .....:..::..|:|.:.|:...:.:.|:....|..:.::.|.:: .|.|     |:.:.| ::|
Zfish    63 SLIYDLFLQWAEKYGPVYRINTLHYVTIVVYCPEATKTIMMSPKY-TKDPFVYRRVFNLFGKRFL 126

  Fly   111 GNGLLLS-DGKVWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNTFDVYRSIC-A 173
            |.||:.: |..:|:::|:|:.|.|..|.|...:..||:.|...:.:|.:.||..|..|...:. .
Zfish   127 GYGLITAVDHDIWYRQRRIMDPAFSSSYLRSLISTFDEMSERLMDKLEEIANNKTPAVMHDLVNC 191

  Fly   174 AALDIIAETAMGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLK-----W 233
            ..||:|.:.|.|..:.....:.:|:..||..|..             .:.|.:..|..:     |
Zfish   192 VTLDVICKVAFGVDLNFLTQKDSPFQNAVELCLK-------------GMTFDVRDPLFRIIPKNW 243

  Fly   234 RQTQLIRTMQEFTIKV----IEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPL 294
            :..|.:|...|...|.    |:.|:.|:::         .|||...    :|..:|.|..:....
Zfish   244 KLIQQVREATELLRKTGEKWIQNRKTAVKN---------GEDVPKD----ILTQILKSAEEQNVT 295

  Fly   295 TNDEIREEVD---TFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDL 356
            :.::..:.:|   ||...|.:||.:.|||.:.||.|:||:..:...|:.:||||  .|.:|..||
Zfish   296 STEDFEQMLDNFVTFFMAGQETTANQLSFAIMELGRNPEIYKRAKAEVDEVLGT--KREISNEDL 358

  Fly   357 GELKYMECVIKESLRMYPPVPIVGRKLQTDFKYTHSVHGDGV-IPAGSEIIIGIFGVHRQPETFP 420
            |:|.|:..|:||:||:||..|...|.|..|...      :|: ||.|..::...|...|..:.|.
Zfish   359 GKLTYLSQVLKETLRLYPTAPGTNRWLHEDMII------NGIKIPGGCSVMFNSFVSQRLEKFFK 417

  Fly   421 NPDEFIPERHENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVR--EYELLPMGQRVEC 483
            :|.:|.|:|.:..:....:...||:.|||.||||.|:|:|.|::|||:::  |:.|:| ||..:.
Zfish   418 DPLKFDPKRFDENAPKPYYTYYPFALGPRTCIGQVFSQMEAKVVLAKLLQRFEFSLVP-GQSFDI 481

  Fly   484 IVNIVLRSETG 494
            .....||.::|
Zfish   482 KDTGTLRPKSG 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	126/452 (28%)
zgc:123299	XP_021324190.1	p450	39..495	CDD:306555	134/493 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820