DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d8 and CYP4F11

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001122404.1	Gene:	CYP4F11 / 57834	HGNCID:	13265	Length:	524	Species:	Homo sapiens

Alignment Length:	523	Identity:	172/523 - (32%)
Similarity:	268/523 - (51%)	Gaps:	59/523 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVVLLFGAGWIIHLGQA------DRRRKVANLPGP-----------ICPPLIGAMQLMLRLNPKT 53
            |::||.|..|::....|      |..|::...|.|           :..|....|        ||
Human    20 LLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGLVTPTEEGM--------KT 76

  Fly    54 FIKVGREYVLKFGHLQRVWI---FNRLLIMSGDAELNEQLLSSQEHLVKHPV--YKVLGQWLGNG 113
            ..::...|...|    ::|:   |..|::...|  :...:.|:...:....:  |..|..|||:|
Human    77 LTQLVTTYPQGF----KLWLGPTFPLLILCHPD--IIRPITSASAAVAPKDMIFYGFLKPWLGDG 135

  Fly   114 LLLSDGKVWHQRRKIITPTFHFSILEQFVEVFDQQSNIC---VQRLAQKANGNTFDVYRSICAAA 175
            ||||.|..|.:.|:::||.|||:||:.::::|::..||.   .||||.:.:.. .|::..|....
Human   136 LLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSAR-LDMFEHISLMT 199

  Fly   176 LDIIAETAMGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIR 240
            ||.:.:.....:...|...| .|..|:.|.:|.:..|...:.|..:.|:.||....::|:.  ..
Human   200 LDSLQKCVFSFESNCQEKPS-EYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRA--CH 261

  Fly   241 TMQEFTIKVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMS-TVDGRPLTNDEIREEVD 304
            .:.:||..||::||..|..|.   :|...::....:.:..:||||:| ..||:.|::::||.|.|
Human   262 LVHDFTDAVIQERRCTLPTQG---IDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEAD 323

  Fly   305 TFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIR--DLGELKYMECVIK 367
            ||||||||||.|.||:.|:.|::|||.|.:..:|:.::| .|| .|:.|.  ||.:|.::...||
Human   324 TFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELL-KDR-EPIEIEWDDLAQLPFLTMCIK 386

  Fly   368 ESLRMYPPVPIVGRKLQTDFKYTHSVHGDG-VIPAGSEIIIGIFGVHRQPETFPNPDEFIPER-- 429
            ||||::||||::.|....||     |..|| |||.|...:|.|.|:|..|..:|:|:.:.|.|
Human   387 ESLRLHPPVPVISRCCTQDF-----VLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFD 446

  Fly   430 HENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLPMGQRVECIVNIVLRSETG 494
            .||....:|...|||||||||||||.||..|||::||..:..:.:||..........::||:|.|
Human   447 QENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELILRAEGG 511

  Fly   495 FQL 497
            ..|
Human   512 LWL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	155/444 (35%)
CYP4F11	NP_001122404.1	p450	52..506	CDD:365848	159/481 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154762
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750