DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d8 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	523	Identity:	192/523 - (36%)
Similarity:	299/523 - (57%)	Gaps:	48/523 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LLFLLVVLLFGAGWII-----HLGQADRRRKVANLPGPICPPLIGAMQLMLRLNPKTFIKVGREY 61
            :||..|:||..|....     ::|:.:..|.:..:.|..  |:|| ..|..:.|...|.....|.
Zfish    12 ILFTAVLLLLLASTAYNPLKNYIGKWNEMRPIPGMAGAY--PIIG-NALQFKTNAGDFFNQIIEG 73

  Fly    62 VLKFGH--LQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHPVYKVLGQWLGNGLLLSDGKVWHQ 124
            ..:..|  |.:||:.....::...||..|.:||:..||.|...|:.|..|||.|||.|.|:.|..
Zfish    74 TNENRHLPLAKVWVGPVPFLILYHAENIEVVLSNSRHLDKSYSYRFLHPWLGTGLLTSTGEKWRN 138

  Fly   125 RRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNTFDVYRSICAAALDIIAETAMGTKIY 189
            |||::|||||||||..|:||.::|::|.:|::.:..:|..|:.:..|...|||||.|||||.|||
Zfish   139 RRKMLTPTFHFSILSDFLEVMNEQTDILIQKMQKLEDGEPFNCFNFITLCALDIICETAMGKKIY 203

  Fly   190 AQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLK--WRQTQLIRTMQEFTIKVIEK 252
            ||:|..:.|.::|.:.:.:::.|..:.:|..:.::.    .||  ....:.::.:..||..||.:
Zfish   204 AQSNADSEYVQSVYKMSDIITKRQRAPWLWPDWIYN----KLKEGKEHAKRLKILHSFTANVIRE 264

  Fly   253 RRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVD-GRPLTNDEIREEVDTFMFEGHDTTTS 316
            |.:.:..:..     :|.|.|.::|.|.||:||.:|.: |:.|::::|:||||||||||||||.:
Zfish   265 RAEFMSSEPD-----SDSDQGERKRQAFLDMLLKTTYENGQKLSHEDIQEEVDTFMFEGHDTTAA 324

  Fly   317 ALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVGR 381
            ::::.||.:..|||||..:..|:.:|.|:. .|.|.:.||.:|:|:|||||||||::|.||:..|
Zfish   325 SMNWALHLIGSHPEVQKAVQAELQEVFGSS-ERHVGVEDLKKLRYLECVIKESLRIFPSVPLFAR 388

  Fly   382 KLQTDFKYTHSVHGDGV-IPAGSEIIIGIFGVHRQPETFPNPDEFIPERH--ENGSRVAPFKMIP 443
            .:      ..:.|.:|. :|.|...:|..:.:||.|..||.|:||.|||.  ||.....|:..||
Zfish   389 SI------CEACHINGFKVPKGVNAVIIPYALHRDPRYFPEPEEFQPERFMPENSKGRHPYAYIP 447

  Fly   444 FSAGPRNCIGQKFAQLEMKMMLAKIVREY---------ELLPMGQRVECIVNIVLRSETGFQLGM 499
            |||||||||||:||.:|.|::||.|:|.:         ||.|:|:       ::||.|.|..:.:
Zfish   448 FSAGPRNCIGQRFAMMEEKVVLATILRHFDVEACQSREELRPLGE-------LILRPEKGIWIKL 505

  Fly   500 RKR 502
            ::|
Zfish   506 QRR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	175/447 (39%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	183/486 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589843
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.850