Protein Alignment Cyp4d8 and cyp46a1.1

DIOPT Version :10

• Sequence 1: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_001018358.1
• Gene: cyp46a1.1 / 553543
• ZFINID: ZDB-GENE-050522-464
• Length: 501
• Species: Danio rerio
• Alignment Length: 527
• Identity: 149/527 - (28%)
• Similarity: 248/527 - (47%)
• Gaps: 77/527 - (14%)

  Fly     2 LLFLLVVLLFGAG-----WIIHLGQADRRRKVANLPGPICPP----LIGAMQLMLR-------LN 50
            ::|.|:..:|.|.     :|.||.|     |..::||   ||    |:|....:.:       |.
Zfish     9 IVFFLLAAVFTAFLGYCLYIHHLHQ-----KYDHIPG---PPRDSFLLGHSSSLTKAVYSDNNLI 65

  Fly    51 PKTFIKVGREYVLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHP-VYKVL-----GQW 109
            ...|:    .:..|:|.:.|:...:.:.||....|..:.::.|.:: :|.| |||.|     .::
Zfish    66 HDLFL----HWAEKYGPVYRINTLHYVTIMVYCPEATKTIMMSPKY-IKDPFVYKQLFNLFGKRF 125

  Fly   110 LGNGLLLS-DGKVWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNTFDVYRSIC- 172
            |||||:.: |..:|:::|:|:.|.|..:.|...:..||:.|...:.:|.:.||..|..|...:.
Zfish   126 LGNGLITAVDHDMWYRQRRIMDPAFSSTYLRSLISTFDEMSERLMDKLEEMANNKTPAVMHDLVN 190

  Fly   173 AAALDIIAETAMGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQ 237
            ...||:|.:.|.|..:.....:.:|:..||..|       ...:.|.|...|....|. .|:..|
Zfish   191 CVTLDVICKVAFGVDLNLLNQKDSPFQNAVELC-------LKGMILDVRDPFFRLFPK-NWKLIQ 247

  Fly   238 LIRTMQEFTIKV----IEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTNDE 298
            .:|...|...|.    |:.|:.|:::         .|||...    :|..:|.|..:.......:
Zfish   248 QVREATELLRKTGEKWIQNRKTAVKN---------GEDVPKD----ILTQILKSAEEENVNNTQD 299

  Fly   299 IREEVD---TFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELK 360
            :.:.:|   ||...|.:||.:.|||.:..|.|:||:..:...|:.:||||  .|.:|..|||:|.
Zfish   300 LEQMLDNFVTFFIAGQETTANQLSFAIMALGRNPEIYKRAKAEVDEVLGT--KREISNEDLGKLT 362

  Fly   361 YMECVIKESLRMYPPVPIVGRKLQTDFKYTHSVHGDGV-IPAGSEIIIGIFGVHRQPETFPNPDE 424
            |:..|:||:||:||..|...|.|..|...      :|: :|.|..::...:...|..:.|.:|.:
Zfish   363 YLSQVLKETLRLYPTAPGTNRWLHEDIVI------NGIKVPRGCSVMFSSYVSQRLEKFFKDPLK 421

  Fly   425 FIPERHENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVR--EYELLPMGQRVECIVNI 487
            |.|||.:..:....:...|||.|||.|:||.|||:|.|::|||:::  |:.|:| ||..:...|.
Zfish   422 FDPERFDVNAPKPYYCYYPFSLGPRTCLGQVFAQMEAKLVLAKLLQRFEFSLVP-GQSFDIKDNG 485

  Fly   488 VLRSETG 494
            .||.::|
Zfish   486 TLRPKSG 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	131/447 (29%)
cyp46a1.1	NP_001018358.1	CYP46A1-like	66..495	CDD:410706	133/462 (29%)