DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d8 and Cyp4e1

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	190/543 - (34%)
Similarity:	289/543 - (53%)	Gaps:	67/543 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLFLLVVLLFGAGWIIHLGQADRRRKVANLPGPICPPLIGAMQLMLRLNPKTFI---------K 56
            :.|.|.:|..|      .||...|:|.:....||...||:|....|  .|..|.|         :
  Fly     9 LALPLFLVTYF------ELGLLRRKRMLNKFQGPSMLPLVGNAHQM--GNTPTEILNRFFGWWHE 65

  Fly    57 VGREYVLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHPVYKVLGQWLGNGLLLSDGKV 121
            .|::..       |.||.....||..:.:..|.:||||..:.|..||.:...|||.|||.|.|..
  Fly    66 YGKDNF-------RYWIGYYSNIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTSTGSK 123

  Fly   122 WHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKAN-GNTFDVYRSICAAALDIIAETAMG 185
            ||:.||:|||.|||:||:.|.||.::.|...:.:|.:.|: ||.||.........||:|.:||||
  Fly   124 WHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICDTAMG 188

  Fly   186 TKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTIKVI 250
            ..|.|..|.|:...:|..:.|..:..|..|.:.:.:.||.....:.::.:|  ::|:|:||.::|
  Fly   189 VSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKT--LKTLQDFTNEII 251

  Fly   251 EKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTNDEIREEVDTFMFEGHDTTT 315
            .||   :|.::|.|......|..|:::||.||.||.|.|||||||:.|:.|||.|||||||||||
  Fly   252 AKR---IEVRKSGLEVGIKADEFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVSTFMFEGHDTTT 313

  Fly   316 SALSFCLHELSRHPEVQAKMLEEIVQVLG-TDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIV 379
            |.:.|.::.|||||:.|.|:..|...|:| :...|..:.:::..:|:::..|||:.|:||.||.:
  Fly   314 SGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFI 378

  Fly   380 GRKLQTDFKYTHSVHGDGVIPAGSEIIIGIFGVHRQPETFPNPDEFIPERHENGSRVAPFKMIPF 444
            ||..:.|:    .:.|| ::|.|:.:.:|:..:......|.:|.:|.|||.:. .:..||:.:||
  Fly   379 GRFTEKDY----VIDGD-IVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERFDR-EKPGPFEYVPF 437

  Fly   445 SAGPRNCIGQKFAQLEMKMMLAKIVREYELLPM----------------------------GQRV 481
            |||||||||||||.||:|.:::||:|.:|:||.                            ..:.
  Fly   438 SAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTLGLQPAEKKSRDAHNHKY 502

  Fly   482 ECIV--NIVLRSETGFQLGMRKR 502
            :.|:  ::.|:||.|..|.|::|
  Fly   503 DPILSASMTLKSENGLHLRMKQR 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	169/462 (37%)
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	172/454 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449038
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	10	9.900