Protein Alignment Cyp4d8 and cyp-25A3

DIOPT Version :10

• Sequence 1: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_001040850.1
• Gene: cyp-25A3 / 4363046
• WormBaseID: WBGene00014697
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 541
• Identity: 130/541 - (24%)
• Similarity: 238/541 - (43%)
• Gaps: 84/541 - (15%)

  Fly     3 LFLLVVLLFGAGWIIH--LGQADR---RRKVANLPGPICPPLIGAMQLMLRLNPKTFIKVGREYV 62
            |.|..:|:....:||:  |.:.:|   |.|: .|.||....|:|.::.::            |..
 Worm     4 LILTSILVSLVSFIIYVILARKERFRLRGKI-GLSGPEPHWLMGNLKQII------------ERK 55

  Fly    63 LKFGHLQRVWIFNRLLIMSGD-------AELNEQLLSSQEHLVKHPVYKVLGQWLGN--GLLLSD 118
            .|.|:......:|:|....|:       .:||..:.:.::  :|....|....:...  ..::.|
 Worm    56 AKLGYDDSYDWYNKLHKQFGETFGIYFGTQLNINITNEED--IKEVFIKNFSNFSDRTPPPIIED 118

  Fly   119 GKV------------WHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKA-NGNTFDVYRS 170
            .|:            |...|..|.|.|....::...|....:.::.::.|.:|| :|..:|:|..
 Worm   119 NKLKESLLQNTYESGWKHTRSAIAPIFSTGKMKAMHETIHSKVDLFLEILKEKASSGQKWDIYDD 183

  Fly   171 ICAAALDIIAETAMGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLK--W 233
            .....||:|.:.|.......|.:.:..:.....:....:..|...: :....||    |.|.  |
 Worm   184 FQGLTLDVIGKCAFAIDSNCQRDRNDVFYVNARKFITNIDIRHSKI-ISTSFLF----PELSKLW 243

  Fly   234 RQTQLIRTMQEFTIKVIE------KRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVD-G 291
            :.......:.:..|.::|      :||:..|..     |:.|          ||.:||....| .
 Worm   244 KVLYRFTDLAKAEIPLVEGLADVYERRRGGEGS-----DSVD----------LLKLLLNREDDKS 293

  Fly   292 RPLTNDEIREEVDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDL 356
            :|:|..|:.|....|:..|::||::|:::|.:.||::|.||.|:.|||::   ...:..::...:
 Worm   294 KPMTKQEVIENCFAFLLAGYETTSTAMTYCSYLLSKYPNVQQKLYEEIME---AKENGGLTYDSI 355

  Fly   357 GELKYMECVIKESLRMYPPV-PIVGRKLQTDFKYTHSVHGDGVIPAGSEIIIGIFGVHRQPETFP 420
            ..:||::.|.||:||.|||| ....|:...|.    ::.|. ..|.|:.::.....|||.||.:.
 Worm   356 HNMKYLDYVYKETLRCYPPVIHFSNRRCLKDI----TIRGQ-FYPKGAIVVCLPHTVHRNPENWD 415

  Fly   421 NPDEFIPERHEN-GSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLPMGQRVECI 484
            :|:||.|||.|| ..:.:..|.|||..|||.|:|.:||::|.|..:||::..:||.......:.|
 Worm   416 SPEEFHPERFENWEEKSSSLKWIPFGVGPRYCVGMRFAEMEFKTTIAKLLDTFELKQFEGEADLI 480

  Fly   485 VN---IVLRSETGFQLGMRKR 502
            .:   :::|.:...:|.::.|
 Worm   481 PDCNGVIMRPKDPVRLHLKPR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	112/466 (24%)
cyp-25A3	NP_001040850.1	CYP3A-like	73..495	CDD:410678	109/451 (24%)