DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d8 and Cyp313a1

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	490	Identity:	133/490 - (27%)
Similarity:	220/490 - (44%)	Gaps:	52/490 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LFLLVVLLFGAGWIIHLGQADRRR---KVANLPGPICPPLIGAMQLMLRLNPKTFIKVGREYVLK 64
            |.|.|..||   ||..|.  .|||   .:..:||||..|::|: .|...:..|..:....:|:.|
  Fly     6 LLLAVGALF---WIYFLW--SRRRLYFLMLKIPGPIGLPILGS-SLENIITYKRKLSFRTKYLNK 64

  Fly    65 FGHLQRVWIFNRLLIMSGDAELNEQLLSSQE-HLVKHPVYKVLGQWLGNGLLLSDGKVWHQRRKI 128
            :|.....|:.....|::.|.::.|.:.||.: |.....:...:...:|||||......|..|||.
  Fly    65 YGSTILTWMGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGKQDPHWLDRRKH 129

  Fly   129 ITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNTFDVYRSICAAALDIIAETAMGTKIYAQAN 193
            ..|:|...:|..|..:||.::.:.:..|....:....||...:...:..|.|:|.||:::  :.:
  Fly   130 FNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKGEIDVVPEMLRWSFKIAAQTTMGSEV--KHD 192

  Fly   194 ESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHL--------KWRQTQLIRTMQEFTIKVI 250
            |.......|....:|:|      :..:.:|..|....:        |.|.....| :|:....|:
  Fly   193 EHFKNGSLVESFESLIS------HSTLNILMPLVQNRMISKICGYDKLRADNFSR-IQKMLDNVV 250

  Fly   251 EKRRQALEDQQSKLMDTADEDVGSKRRMALL---DVLLMSTVDGRPLTNDEIREEVDTFMFEGHD 312
            .|:...|....|    ..:.::...|.|.|.   |:..|           :::.|....:..|:|
  Fly   251 NKKVNPLPKTDS----DPESNIVINRAMELYRKGDITYM-----------DVKSECCIMIAAGYD 300

  Fly   313 TTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVP 377
            |:...:...|..|:.|||.|..:.||:..|........::..|:.:|.|:|.||||:||:.|.:|
  Fly   301 TSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYLERVIKETLRLIPAIP 365

  Fly   378 IVGRKLQTDFKYTHSVHGDGVIPAGSEIIIGIFGVHRQPETF-PNPDEFIPERH--ENGSRVAPF 439
            |..|:.:.|.:.::.|    :||.|..|.|.:|..||.||.: |:.|.|.|:..  ||..:..|:
  Fly   366 ITARETKNDVRLSNGV----LIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFLAENMEQKHPY 426

  Fly   440 KMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYEL 474
            ..|||:.|.|||||.|:|.:..|..|.:|:|.|::
  Fly   427 AYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKI 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	112/424 (26%)
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	122/458 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	4	3.960