DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d8 and cyp46a1.4

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	XP_005160404.1	Gene:	cyp46a1.4 / 393451	ZFINID:	ZDB-GENE-040426-1224	Length:	501	Species:	Danio rerio

Alignment Length:	521	Identity:	144/521 - (27%)
Similarity:	248/521 - (47%)	Gaps:	65/521 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LLFLLVVLLFGA--GWIIHLGQADRRRKVANLPGP--------ICPPLIGAMQLMLRLNPKTFIK 56
            ::|.|:..:|.|  .:.:::...  .:|..::|||        ..|.|..:|.....|....|:
Zfish     9 IIFYLLSAVFTAFLAYCLYIHYV--HQKYDHIPGPPRDNFLFGHSPSLTKSMYADDSLIHDLFL- 70

  Fly    57 VGREYVLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHP-VYKVL-----GQWLGNGLL 115
               ::..|:|.:.|:...:.:.|:....|..:.:|.|.:: .|.| ||:.|     .::||.||:
Zfish    71 ---QWAEKYGPVYRINSLHYIAIVVHCPEATKTILMSPKY-TKDPFVYRRLFNLFGKRFLGYGLI 131

  Fly   116 LS-DGKVWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNTFDVYRSIC-AAALDI 178
            .: |..:|:::|:|:.|.|..|.|...:..||:.|...:.:|.:.||..|..|...:. ...||:
Zfish   132 TAVDHDIWYRQRRIMDPAFSSSYLRSLISTFDEMSERLMDKLEEMANNKTPAVMHDLVNCVTLDV 196

  Fly   179 IAETAMGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQ 243
            |.:.|.|..:...|.:.:|:..||..|.     ..|:|.|: :..|.|...:  |:....||...
Zfish   197 ICKVAFGVDLNFLAQKDSPFQNAVELCL-----NGMTVDLR-DPFFRLFPKN--WKLIHQIRDAA 253

  Fly   244 EFTIKV----IEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTNDEIREEVD 304
            |...|.    |:.|:.|:::         .|||...    :|..:|.|..:......|::.:.:|
Zfish   254 ELLRKTGEKWIQNRKTAVKN---------GEDVPKD----ILTQILKSAEEENVNNTDDLEQMLD 305

  Fly   305 ---TFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVI 366
               ||...|.:||.:.|||.:..|.|:||:..:...|:.:||||  .|.:|..|||:..|:..|:
Zfish   306 NFVTFFIAGQETTANQLSFAIMALGRNPEIYKRAKAEVDEVLGT--KREISNEDLGKFTYLSQVL 368

  Fly   367 KESLRMYPPVPIVGRKLQTDFKYTHSVHGDGV-IPAGSEIIIGIFGVHRQPETFPNPDEFIPERH 430
            ||:||:||..|...|.|..|...      :|: ||.|..::...:...|..:.|.:|.:|.|||.
Zfish   369 KETLRLYPTAPGTNRWLHEDMVI------NGIKIPGGCSVMFSSYVSQRLEKFFKDPLKFDPERF 427

  Fly   431 ENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVR--EYELLPMGQRVECIVNIVLRSET 493
            :..:....:...||:.|||.|:||.|:|:|.|::|||:::  |:.|:| ||..:......||.::
Zfish   428 DVNAPKPYYCYFPFALGPRTCLGQVFSQMEAKVVLAKLLQRFEFSLVP-GQSFDIKDTGTLRPKS 491

  Fly   494 G 494
            |
Zfish   492 G 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	130/447 (29%)
cyp46a1.4	XP_005160404.1	p450	39..495	CDD:278495	139/489 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810