DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d8 and Cyp3a44

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_796354.1	Gene:	Cyp3a44 / 337924	MGIID:	2449818	Length:	504	Species:	Mus musculus

Alignment Length:	501	Identity:	137/501 - (27%)
Similarity:	238/501 - (47%)	Gaps:	70/501 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLFLLVVLLFGAGWIIHLGQADRRRKVANLPGPICPPLIGAMQLMLRLNPKTFI-KVGREYVLK 64
            :||.:::|||:..|...|     ...|...:|||...|.:|.:     ||..|.| |...|...|
Mouse    13 VLLAIILVLLYRYGTRTH-----GLFKKQGIPGPKPLPFLGTV-----LNYYTGIWKFDMECYEK 67

  Fly    65 FGHLQRVW-IFNRLLIMSGDAELNEQLLSSQEHLVKHPVYK-VLGQW-----------LGNGLLL 116
            :|   :.| :|:      |...|   |:.:....:|:.:.| .|..:           :...:.:
Mouse    68 YG---KTWGLFD------GQTPL---LVITDPETIKNVLVKDCLSVFTNRREFGPVGIMSKAISI 120

  Fly   117 SDGKVWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNTFDVYRSICAA-ALDIIA 180
            |..:.|.:.|.:::|||....|::...|.:|..:|.|:.|.|:|........:.:..| ::|:|.
Mouse   121 SKDEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQEAEKGMPVAMKDVLGAYSMDVIT 185

  Fly   181 ETAMGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLI-RTMQE 244
            .|:.|..:.:..|...|:.|   |....|...|....|...:||.|..|..:.....:. ....|
Mouse   186 STSFGVNVDSLNNPEDPFVE---EAKKFLRVDFFDPLLFSVVLFPLLTPVYEMLNICMFPNDSIE 247

  Fly   245 FTIKVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDG------RPLTNDEIREEV 303
            |..|.:::.      |:|:|      |...|.|:..|.:::.|..:.      :..:|.||..:.
Mouse   248 FFKKFVDRM------QESRL------DSNQKHRVDFLQLMMNSHNNSKDKDSHKAFSNMEITVQS 300

  Fly   304 DTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKE 368
            ..|:..|::||:|.|||.|:.|:.||::|.|:..||.:.| .:::.| :...:.|::|::.|:.|
Mouse   301 IIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKAL-PNKATP-TCDTVMEMEYLDMVLNE 363

  Fly   369 SLRMYPPVPIVGRKLQTDFKYTHSVHGDGV-IPAGSEIIIGIFGVHRQPETFPNPDEFIPER--H 430
            :||:||.|..:.|..:.|      |..:|| ||.||.::|..:.:|..|:.:|:|:||.|||  .
Mouse   364 TLRLYPIVTRLERVCKKD------VELNGVYIPKGSMVMIPSYALHHDPQHWPDPEEFQPERFSK 422

  Fly   431 ENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLP 476
            ||...:.|:..:||..|||||||.:||.:.||:.:.|:::.:...|
Mouse   423 ENKGSIDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQP 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	117/435 (27%)
Cyp3a44	NP_796354.1	p450	39..494	CDD:278495	129/470 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840