DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d8 and Cyp4ac2

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_608917.3	Gene:	Cyp4ac2 / 33755	FlyBaseID:	FBgn0031694	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	451	Identity:	156/451 - (34%)
Similarity:	249/451 - (55%)	Gaps:	28/451 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 GREYVLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHPVYKVLGQWLGNGLLLSDGKVW 122
            ||.|:..|.|.....|..        ||..|::|.|.:.:.|:.:|::|..:||.|||:|..:.|
  Fly    84 GRNYLWYFFHAPMYNIVR--------AEEAEEILQSSKLITKNMIYELLKPFLGEGLLISTDQKW 140

  Fly   123 HQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNTFDVYRSICAAALDIIAETAMGTK 187
            |.|||.:||.|||.:|:.|:.:|.::.|..|:.|.|..| ...::.:.|....|:.:.|||:|.|
  Fly   141 HSRRKALTPAFHFKVLQSFLIIFKEECNKLVKVLHQSVN-MELELNQVIPQFTLNNVCETALGVK 204

  Fly   188 IYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTIKVIEK 252
            : ...:|...|.::::....::..|..:.:....:.|.|...:.|  |...::...||:..:|||
  Fly   205 L-DDLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYFFLFGDYRK--QVNNLKIAHEFSSNIIEK 266

  Fly   253 RRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTNDEIREEVDTFMFEGHDTTTSA 317
            ||...:..|.    ..:::.|.|:|.|:||.||.:..||: :.:..|.:||:||||||:|||::.
  Fly   267 RRSLFKSNQL----GQEDEFGKKQRYAMLDTLLAAEADGQ-IDHQGICDEVNTFMFEGYDTTSTC 326

  Fly   318 LSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVGRK 382
            |.|.|..|:.|.:||.|..|||..:  .|.|..:|:....||.|||||||||||::|.||.:||:
  Fly   327 LIFTLLMLALHEDVQKKCYEEIKYL--PDDSDDISVFQFNELVYMECVIKESLRLFPSVPFIGRR 389

  Fly   383 LQTDFKYTHSVHGDGVIPAGSEIIIGIFGVHRQPETFPNPDEFIPERH--ENGSRVAPFKMIPFS 445
            ...:     .|....::|..::|.|.::.:.|....|.||..|.|:|.  ||.....||..:|||
  Fly   390 CVEE-----GVVNGLIMPKNTQINIHLYEIMRDARHFSNPKMFQPDRFFPENTVNRHPFAFVPFS 449

  Fly   446 AGPRNCIGQKFAQLEMKMMLAKIVREYELLPMGQRVECIV--NIVLRSETGFQLGMRKRKH 504
            ||.|||||||||.||:|::||.::|.:::||:....:...  .||||::...::.:..|::
  Fly   450 AGQRNCIGQKFAILEIKVLLAAVIRNFKILPVTLLDDLTFENGIVLRTKQNIKVKLVHREN 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	151/434 (35%)
Cyp4ac2	NP_608917.3	p450	57..505	CDD:278495	155/444 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460519
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	9.000