DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d8 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_796281.1	Gene:	Cyp4f39 / 320997	MGIID:	2445210	Length:	532	Species:	Mus musculus

Alignment Length:	527	Identity:	169/527 - (32%)
Similarity:	269/527 - (51%)	Gaps:	61/527 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLVVLLFGAGWIIHLGQ--ADRR---RKVANLPGPICPP----LIGAMQLMLRLNPKTFIKVGRE 60
            ||:||.|....::...:  :|.|   ||::..|.   ||    |:|.|.:.|. |.|. ::..::
Mouse    28 LLLVLFFFFRLLVRAFKLFSDFRITCRKLSCFPE---PPGRHWLLGHMSMYLP-NEKG-LQNEKK 87

  Fly    61 YVLKFGHLQRVWI--FNRLLIMSGDAELNEQLLSSQEHLVKHP-VYKVLGQWLGNGLLLSDGKVW 122
            .:....|:...|:  |..||::.....:...|.:|.....|.. .|..|..|||:|||:|.|..|
Mouse    88 VLDTMHHIILAWVGPFLPLLVLVHPDYIKPVLGASAAIAPKDEFFYSFLKPWLGDGLLISKGNKW 152

  Fly   123 HQRRKIITPTFHFSILEQFVEVFDQQSNIC---VQRLAQKANGNTFDVYRSICAAALDIIAETAM 184
            .:.|:::||.|||.||:.::::|:|.:||.   .:|...:.:..:||::..|....||.:.:...
Mouse   153 SRHRRLLTPAFHFDILKPYMKIFNQCTNIMHAKWRRHLAEGSVTSFDMFEHISLMTLDSLQKCVF 217

  Fly   185 GTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTIKV 249
            ......|...| .|..::.|.:||:..|...::..::.::.||....::||.  ..|:..||.:|
Mouse   218 SYNSDCQERMS-DYISSIIELSALVVRRQYRLHHYLDFMYYLTADGRRFRQA--CDTVHNFTTEV 279

  Fly   250 IEKRRQALEDQ---------QSKLMDTADEDVGSKRRMALLDVLLMS-TVDGRPLTNDEIREEVD 304
            |::|||||..|         |.|.:|             .:||||:: ..:|:.|::::||.|.|
Mouse   280 IQERRQALRQQGAEAWLKAKQGKTLD-------------FIDVLLLAKDEEGKELSDEDIRAEAD 331

  Fly   305 TFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKES 369
            ||||||||||:|.||:.|..|:::||.|.|..|||.:|:.......:...||.:|.:....||||
Mouse   332 TFMFEGHDTTSSGLSWALFNLAKYPEYQEKCREEIQEVMKGRELEELDWDDLTQLPFTTMCIKES 396

  Fly   370 LRMYPPVPIVGRKLQTDFKYTHSVHGDG-VIPAGSEIIIGIFGVHRQPETFP-----NPDEFIPE 428
            ||.:|||.::.|:...|.|..     || |||.|...::.|:|.|..|..:|     ||..|.|:
Mouse   397 LRQFPPVTLISRRCTEDIKLP-----DGRVIPKGIICLVSIYGTHHNPIVWPDSKVYNPYRFDPD 456

  Fly   429 RHENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYEL-LPMGQRVECIVNIVLRSE 492
            ..:..|   |...:||||||||||||.||..||::::|..:..:.| :....:|.....::||:|
Mouse   457 TPQQRS---PLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRLSVDRTHKVRRKPELILRTE 518

  Fly   493 TGFQLGM 499
            .|..|.:
Mouse   519 NGLWLNV 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	150/453 (33%)
Cyp4f39	NP_796281.1	p450	60..515	CDD:365848	155/483 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844906
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750