DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d8 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	XP_006241152.1	Gene:	Cyp4f39 / 299566	RGDID:	1308796	Length:	550	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	166/528 - (31%)
Similarity:	271/528 - (51%)	Gaps:	63/528 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LLFLLVVLLFGAGWIIHLGQADRR---RKVANLPGPICPP----LIGAMQLMLRLNPKTFIKVGR 59
            |||||..||..|..:.    :|.|   |:::..|.   ||    |:|.|.:.|. |.|. ::..:
  Rat    31 LLFLLFRLLLQAFKLF----SDFRITCRRLSCFPE---PPGRHWLLGHMSMYLP-NEKG-LQNEK 86

  Fly    60 EYVLKFGHLQRVWI--FNRLLIMSGDAELNEQLLSSQEHLVKHP-VYKVLGQWLGNGLLLSDGKV 121
            :.:....|:...|:  |..||::.....:...|.:|.....|.. .|..|..|||:|||:|.|..
  Rat    87 KVLDTMHHIILAWVGPFLPLLVLVHPDYIKPVLGASAAIAPKDEFFYSFLKPWLGDGLLISKGNK 151

  Fly   122 WHQRRKIITPTFHFSILEQFVEVFDQQSNIC---VQRLAQKANGNTFDVYRSICAAALDIIAETA 183
            |.:.|:::||.|||.||:.::::|:|..||.   .:|...:.:..:||::..:....||.:.:..
  Rat   152 WSRHRRLLTPAFHFDILKPYMKIFNQSVNIMHAKWRRHLAEGSVTSFDMFEHVSLMTLDSLQKCV 216

  Fly   184 MGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTIK 248
            .......| .:.:.|..::.|.:||:..|...::..::.::.||....::||.  ..|:..||.:
  Rat   217 FSYSSDCQ-EKLSDYISSIIELSALVVRRQYRLHHYLDFIYYLTADGRRFRQA--CDTVHNFTTE 278

  Fly   249 VIEKRRQALED---------QQSKLMDTADEDVGSKRRMALLDVLLMS-TVDGRPLTNDEIREEV 303
            ||::||:||.:         :|.|.:|             .:||||:: ..:|:.|::::||.|.
  Rat   279 VIQQRRRALRELGAEAWLKAKQGKTLD-------------FIDVLLLAKDEEGKELSDEDIRAEA 330

  Fly   304 DTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKE 368
            |||||||||||:|.||:.|..|:::||.|.|..|||.:|:.......:...||.:|.:....|||
  Rat   331 DTFMFEGHDTTSSGLSWALFNLAKYPEYQDKCREEIQEVMKGRELEELDWDDLTQLPFTTMCIKE 395

  Fly   369 SLRMYPPVPIVGRKLQTDFKYTHSVHGDG-VIPAGSEIIIGIFGVHRQPETFP-----NPDEFIP 427
            |||.:|||.::.|:...|.|..     || :||.|...::.|:|.|..|..:|     ||..|.|
  Rat   396 SLRQFPPVTLISRRCTEDIKLP-----DGRIIPKGIICLVSIYGTHYNPLVWPDSKVYNPYRFDP 455

  Fly   428 ERHENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYEL-LPMGQRVECIVNIVLRS 491
            :..:..|   |...:||||||||||||.||..||::::|..:..:.| :...::|.....::||:
  Rat   456 DIPQQRS---PLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRLSVDRTRKVRRKPELILRT 517

  Fly   492 ETGFQLGM 499
            |.|..|.:
  Rat   518 ENGLWLNV 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	145/453 (32%)
Cyp4f39	XP_006241152.1	CYP4F	82..523	CDD:410772	145/464 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348374
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750