DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d8 and Cyp4a3

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	XP_038965516.1	Gene:	Cyp4a3 / 298423	RGDID:	631356	Length:	511	Species:	Rattus norvegicus

Alignment Length:	410	Identity:	133/410 - (32%)
Similarity:	218/410 - (53%)	Gaps:	26/410 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 VYKVLGQWL----GNGLLLSDGKVWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQ-KAN 161
            :|:.|..|:    |.||||.:||.|.|..:::||.||:.||:.:|::.....:|.:.:..: ...
  Rat   116 IYQFLAPWIVSGTGYGLLLLNGKKWFQHWRMLTPAFHYGILKPYVKIMADSVSIMLDKWEKLDDQ 180

  Fly   162 GNTFDVYRSICAAALDIIAETAMGTKIYAQAN-ESTPYAEAVNECTALLSWRFMSVYLQVELLFT 225
            .:..:::..:....||.:.:.|...:...|.: .|..|.:||.:...|..:|..|.:....:::.
  Rat   181 DHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLDVNSRSYTKAVEDLNNLTFFRVRSAFYGNSIIYN 245

  Fly   226 LTHP-HLKWRQTQLIRTMQEFTIKVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTV 289
            ::.. .|..|..|:   ..|.|..||:.|:..|::::..      :....||.:..||:||.:.:
  Rat   246 MSSDGRLSRRACQI---AHEHTDGVIKMRKAQLQNEEEL------QKARKKRHLDFLDILLFAKM 301

  Fly   290 -DGRPLTNDEIREEVDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSI 353
             ||:.|:::::|.|||||||||||||.|.:|:..:.|:.|||.|.:..||:..:||...|  |:.
  Rat   302 EDGKSLSDEDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSILGDGTS--VTW 364

  Fly   354 RDLGELKYMECVIKESLRMYPPVPIVGRKLQTDFKYTHSVHGDG-VIPAGSEIIIGIFGVHRQPE 417
            ..|.::.|....|||:||:|||||.|.|:|.:...:.     || .||.|....|.|:|:|..|.
  Rat   365 DHLDQISYTTMCIKEALRLYPPVPSVSRELSSPVTFP-----DGRSIPKGITTTILIYGLHHNPS 424

  Fly   418 TFPNPDEFIPERHENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLPMGQRVE 482
            .:|||..|.|.|....|.......:|||.|.|||||::||..|:|:.:|..:..:||||...|:.
  Rat   425 YWPNPKVFDPSRFSPDSPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIP 489

  Fly   483 C-IVNIVLRSETGFQLGMRK 501
            . :..:||:|:.|..|.::|
  Rat   490 VPMARLVLKSKNGIHLRLKK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	131/404 (32%)
Cyp4a3	XP_038965516.1	CYP4B-like	69..506	CDD:410771	131/405 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348464
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750