DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4d8 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001129072.1	Gene:	Cyp4v3 / 266761	RGDID:	708530	Length:	525	Species:	Rattus norvegicus

Alignment Length:	493	Identity:	188/493 - (38%)
Similarity:	280/493 - (56%)	Gaps:	55/493 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PLIGAMQLMLRLNPKTFIKVGREYVLKFGHLQ--RVWIFNRLLIMSGDAELNEQLLSSQEHLVKH 100
            ||:| ..|.::.|...|.:...:|..:|.||.  ::||....|:....||..|.:|:|.:.:.|.
  Rat    58 PLVG-HALFMKPNNTEFFQQIIQYTEEFRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQIDKS 121

  Fly   101 PVYKVLGQWLGNGLLLSDGKVWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNTF 165
            .:||.|..|||.|||.|.|..|..|||::||:|||:|||.|::|.::|:||.|.:|.:..|...|
  Rat   122 FMYKFLQPWLGLGLLTSTGSKWRARRKMLTPSFHFTILEDFLDVMNEQANILVNKLEKHVNQEAF 186

  Fly   166 DVYRSICAAALDIIAETAMGTKIYAQANESTPYAEAVNECTAL------LSWRFMSVYLQVELLF 224
            :.:..|...|||||.|||||..|.||:|..:.|...|...:.:      :.|.:..::.   |:|
  Rat   187 NCFFPITLCALDIICETAMGKNIGAQSNGDSEYVRTVYRMSDMIYRRMKMPWFWFDLWY---LMF 248

  Fly   225 TLTHPHLKWRQTQLIRTMQEFTIKVIEKRRQALEDQQSKLMDTADEDVGSKR--------RMALL 281
            .....|.|.     ::::..||..||.:|..|.:.:|        :.:|:.|        |.|.|
  Rat   249 KEGRDHKKG-----LKSLHTFTNNVIAERVNARKAEQ--------DCIGAGRGPLPSKTKRKAFL 300

  Fly   282 DVLLMST-VDGRPLTNDEIREEVDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGT 345
            |:||..| .:|..|::::||||||||||||||||.:|:::.|:.|..:||||.|:.:|:..|.|.
  Rat   301 DLLLSVTDEEGNKLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQRKVDKELDDVFGR 365

  Fly   346 DRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVGRKLQTD-----FKYTHSVHGDGVIPAGSEI 405
            .. |||::.||.:|||::|||||:||::|.||:..|.|..|     :|          |..|:|.
  Rat   366 SH-RPVTLEDLKKLKYLDCVIKETLRVFPSVPLFARSLSEDCEVAGYK----------ISKGTEA 419

  Fly   406 IIGIFGVHRQPETFPNPDEFIPERH--ENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKI 468
            :|..:.:||.|..||:|:||.|||.  ||.....|:..:|||||||||||||||.:|.|.:||.|
  Rat   420 VIIPYALHRDPRYFPDPEEFQPERFFPENSQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACI 484

  Fly   469 VREYELLPMGQRVECIV--NIVLRSETGFQLGMRKRKH 504
            :||:.:....:|.|..:  :::||...|..:.: ||:|
  Rat   485 LREFWIESNQKREELGLAGDLILRPNNGIWIKL-KRRH 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	177/456 (39%)
Cyp4v3	NP_001129072.1	CYP4V	76..515	CDD:410773	179/465 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348395
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850