Protein Alignment Cyp4d8 and CYP4X1

DIOPT Version :9

• Sequence 1: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 141/503 - (28%)
• Similarity: 250/503 - (49%)
• Gaps: 63/503 - (12%)

  Fly    39 LIGAMQLMLRLN-----------PKTFIKVGREYVLKFGHLQRV-------------WI--FNRL 77
            |:.|::|.||..           |.|...:|.:..::..:::::             ||  |...
Human    26 LLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRAFPFWIGPFQAF 90

  Fly    78 LIMSGDAELNEQLLSSQEHLVKHPVYKVLGQWLGNGLLLSDGKVWHQRRKIITPTFHFSILEQFV 142
            ..:. |.:..:.|||..:...:: :.|.....||.||...||..|.|.|:::||.|||:||:.::
Human    91 FCIY-DPDYAKTLLSRTDPKSQY-LQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYI 153

  Fly   143 EV--------FDQQSNICVQRLAQKANGNTFDVYRSICAAALDIIAETAMGTKIYAQANES-TPY 198
            ||        .|:...||      .....:.:||..|.:.:||||.:.|...:...|.|.: .||
Human   154 EVMAHSVKMMLDKWEKIC------STQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPY 212

  Fly   199 AEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTIKVIEKRRQALEDQQSK 263
            |:|:.|.:.::..|..|:....:::|.|: |. .:|..:|.|.:.::|..:|::|:::|:
Human   213 AKAIFELSKIIFHRLYSLLYHSDIIFKLS-PQ-GYRFQKLSRVLNQYTDTIIQERKKSLQ----- 270

  Fly   264 LMDTADEDVGSKRRMALLDVLLMSTVD-GRPLTNDEIREEVDTFMFEGHDTTTSALSFCLHELSR 327
             .....::...::....||::|.:..: |...::.::..||.||:..||||..:::|:.|:.|:.
Human   271 -AGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLAL 334

  Fly   328 HPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVGRKLQTDFKYTHS 392
            :||.|.:..||:..:||...|  ::...|||:.|....|||:.|:.|.||.:.|.|.....:.
Human   335 NPEHQERCREEVRGILGDGSS--ITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFP-- 395

  Fly   393 VHGDG-VIPAGSEIIIGIFGVHRQPETFPNPDEFIPER--HENGSRVAPFKMIPFSAGPRNCIGQ 454
               || .:|||..:::.|:|:|..|..:.||..|.|.|  .||..:..|:..:|||||.||||||
Human   396 ---DGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQ 457

  Fly   455 KFAQLEMKMMLAKIVREYELLPMGQRVECIVN-IVLRSETGFQLGMRK 501
            :||.:|:|:.:|.|:..:.:.|...|.....| .:|:.:.|..|.::|
Human   458 EFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMYLHLKK 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	131/459 (29%)
CYP4X1	NP_828847.1	p450	47..501	CDD:306555	134/476 (28%)
		heme binding region	447..460		10/12 (83%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154706
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750