DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d8 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	164/530 - (30%)
Similarity:	271/530 - (51%)	Gaps:	76/530 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLFLLVVLLFGAGWIIHLGQADRRRKVA----NLPGPICPPLIG-AMQLMLRLNPKTFIKVGR- 59
            ::|.::|:.||..        ..||:|:|    :.|||....|.| |:::.         |:|.
  Rat    20 VILMVIVLKLFSL--------LLRRQKLARAMDSFPGPPTHWLFGHALEIQ---------KLGSL 67

  Fly    60 ----EYVLKFGHLQRVWI-------------FNRLLIMSGDAELNEQLLSSQEHLVKHPVYKVLG 107
                .:..:|.|...:|.             :.:.:...||.:..:             ||....
  Rat    68 DKVVSWAQQFPHAHPLWFGQFVGFLNIYEPDYAKAVYSRGDPKAAD-------------VYDFFL 119

  Fly   108 QWLGNGLLLSDGKVWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGN-TFDVYRSI 171
            ||:|.|||:.||..|.|.||::||.||:.:|:.:|.:|.:.:.:.:.:..:||:.| :||::..:
  Rat   120 QWIGKGLLVLDGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASENKSFDIFCDV 184

  Fly   172 CAAALDIIAETAMGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQT 236
            ...|||.:.:...|.......:....|..||::.|.|:..|..|.....:.::.|| ||.: |..
  Rat   185 GHMALDTLMKCTFGKGDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLT-PHGR-RFL 247

  Fly   237 QLIRTMQEFTIKVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLL-MSTVDGRPLTNDEIR 300
            :..:...:.|.:||.:|:.||:|::.:      :.:..:|.:..||:|| :....|..|::.|:|
  Rat   248 RACKIAHDHTDEVIRQRKAALQDEKER------KKIQQRRHLDFLDILLGVRDESGIKLSDAELR 306

  Fly   301 EEVDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECV 365
            .|||||||||||||||.:|:.|:.::.:||.|....||:..:||...|  ....||.::.|:...
  Rat   307 AEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVRGILGDQDS--FQWDDLAKMTYLTMC 369

  Fly   366 IKESLRMYPPVPIVGRKLQTDFKYTHSVHGDG-VIPAGSEIIIGIFGVHRQPETFPNPDEFIPER 429
            :||..|:|||||.|.|:|.....:.     || .:||||.|.:.|:.:||....:|:|:.|.|.|
  Rat   370 MKECFRLYPPVPQVYRQLNKPVTFV-----DGRSLPAGSLISLHIYALHRNSTVWPDPEVFDPLR 429

  Fly   430 H--ENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAK-IVR-EYELLPMGQRVECIVNIVLR 490
            .  ||.:...||..:||||||||||||:||..|||::.|. ::| |:.|.|....:: :..::||
  Rat   430 FSPENAAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSLDPSKMPIK-VPQLILR 493

  Fly   491 SETGFQLGMR 500
            |:.|..|.::
  Rat   494 SKNGIHLYLK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	146/450 (32%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	155/490 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348662
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750