DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d8 and Tbxas1

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_035669.3	Gene:	Tbxas1 / 21391	MGIID:	98497	Length:	533	Species:	Mus musculus

Alignment Length:	568	Identity:	138/568 - (24%)
Similarity:	233/568 - (41%)	Gaps:	140/568 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLVVLLFGAGWIIHLGQADRRRKVANLPGPICPPLIGAMQLMLRLNPKTFIKVG--------REY 61
            |||.||....|  :...|..|.:...:..|...|.:|.:.         |.:.|        ||
Mouse    20 LLVALLALLKW--YSMSAFSRLEKLGIRHPKPSPFVGNLM---------FFRQGFWESQLELRE- 72

  Fly    62 VLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHPVYKVLGQWLGNG----------LLL 116
              ::|.|...::..|:.::..:.::.:|:|...        :......:.:|          |||
Mouse    73 --RYGPLCGYYLGRRMHVVISEPDMIKQVLVEN--------FSNFSNRMASGLEPKMVADSVLLL 127

  Fly   117 SDGKVWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQ-KANGNTFDVYRSICAAALDIIA 180
            .|.: |.:.|..:..:|....|::...:..|...:.|..|.: .|:.:.|::.|..|...:|::|
Mouse   128 RDRR-WEEVRGALMSSFSPEKLDEMTPLISQACELLVAHLKRYAASRDAFNIQRCYCCYTIDVVA 191

  Fly   181 ETAMGTKIYAQANESTPYAEAVNECTA----------LLSWRFMSVYLQVELLFTLTHPHLKWRQ 235
            ..|.||::.:|.:...|:.:.....:.          :||:..:.|.| ..:|.......|....
Mouse   192 SVAFGTQVDSQNSPEDPFVQHCRRASTFCIPRPLLVLILSFPSIMVPL-ARILPNKNRDELNGFF 255

  Fly   236 TQLIRTMQEFTIKVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLL-----MSTV------ 289
            ..|||       .||     ||.|||:     |:|     ||...|.::|     |::|
Mouse   256 NTLIR-------NVI-----ALRDQQA-----AEE-----RRRDFLQMVLDAQHSMNSVGVEGFD 298

  Fly   290 -----------------------DGRPLTNDEIREEVDTFMFEGHDTTTSALSFCLHELSRHPEV 331
                                   ..:|.|.|||..:...|:..||:..|:.|||..:.|:.||:.
Mouse   299 MVPESLSSSECTKEPPQRCHPTSTSKPFTVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDC 363

  Fly   332 QAKMLEEIVQVLGTDRSRPV-SIRDLGE-LKYMECVIKESLRMYPPVPIVGRKLQTDFKYTHSVH 394
            |.::|:|:...:|   ..|. ....|.| |.|::.||.|:||||||.          |::|....
Mouse   364 QERLLKEVDLFMG---KHPAPEYHSLQEGLPYLDMVISETLRMYPPA----------FRFTREAA 415

  Fly   395 GD-----GVIPAGSEIIIGIFGVHRQPETFPNPDEFIPERHENGSRV--APFKMIPFSAGPRNCI 452
            .|     ..||||:.:.|.:..:|..||.:|||:.|.|||....:|:  .||..:||.||||:|:
Mouse   416 QDCEVLGQRIPAGTVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQRRPFTYLPFGAGPRSCL 480

  Fly   453 GQKFAQLEMKMMLAKIVRE--YELLPMGQRVECIVNIVLRSETGFQLG 498
            |.:...|.:|:.:.:::.:  :|..|..|       :.|:.|:...||
Mouse   481 GVRLGLLVVKLTILQVLHKFRFEASPETQ-------VPLQLESKSALG 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	121/496 (24%)
Tbxas1	NP_035669.3	p450	47..528	CDD:365848	130/539 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930