Protein Alignment Cyp4d8 and CYP4Z1

DIOPT Version :10

• Sequence 1: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 145/515 - (28%)
• Similarity: 253/515 - (49%)
• Gaps: 49/515 - (9%)

  Fly     1 MLLFLLVVLLFGAGWIIHLGQADRRRKVANLPGPICPPLIGAMQLMLRLNPKTFIKVGREYVLKF 65
            :|||.::.|.....|:|        |.:...|.|......|..:..    |....:|..:.:.|:
Human    24 LLLFQVIRLYQRRRWMI--------RALHLFPAPPAHWFYGHKEFY----PVKEFEVYHKLMEKY 76

  Fly    66 GHLQRVWIFNRLLIMS-GDAELNEQLLSSQE--HLVKHPVYKVLGQWLGNGLLLSDGKVWHQRRK 127
            .....:|:....:..| .|.:..:.||..|:  ..|.|   |:|..|:|.||:..||..|.:.|:
Human    77 PCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSH---KILESWVGRGLVTLDGSKWKKHRQ 138

  Fly   128 IITPTFHFSILEQFVEVFDQQSNICVQRLAQK-ANGNTFDVYRSICAAALDIIAETAMGTKIYAQ 191
            |:.|.|:.|||:.|:.:..:...:.:.:..:. |..:..::::.:....||.|.:.|...:...|
Human   139 IVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQ 203

  Fly   192 ANES-TPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLI----RTMQEFTIKVIE 251
            .:.: ..|.:||...:.:.:.|..:.....:|:|..:      .|.|:.    :.:.:||.|||:
Human   204 LDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFS------SQGQIFSKFNQELHQFTEKVIQ 262

  Fly   252 KRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDG-RPLTNDEIREEVDTFMFEGHDTTT 315
            .|:::|:|:       ..:|...|||...||:||.:..:. :..:..:::.||.||||.|||||:
Human   263 DRKESLKDK-------LKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTS 320

  Fly   316 SALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVG 380
            ||:|:.|:.|:::||.|.:..:||.::||...|  ::...|.::.|....|||.||:|.||..:.
Human   321 SAISWILYCLAKYPEHQQRCRDEIRELLGDGSS--ITWEHLSQMPYTTMCIKECLRLYAPVVNIS 383

  Fly   381 RKLQTDFKYTHSVHGDG-VIPAGSEIIIGIFGVHRQPETFPNPDEFIPER--HENGSRVAPFKMI 442
            |.|.....:.     || .:|||..:.|.|:.:|..|..:.:|..|.|.|  .||..::.|:..|
Human   384 RLLDKPITFP-----DGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFI 443

  Fly   443 PFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLPMGQR-VECIVNIVLRSETGFQLGMRK 501
            |||||.||||||.||.:|.|:.:|..:..::|.|...| .:.:..:||:|:.|..:..:|
Human   444 PFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHVFAKK 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	131/444 (30%)
CYP4Z1	NP_835235.1	CYP4B-like	66..500	CDD:410771	133/456 (29%)