DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4d8 and Cyp4f13

DIOPT Version :9

Sequence 1:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_570952.1	Gene:	Cyp4f13 / 170716	MGIID:	2158641	Length:	523	Species:	Mus musculus

Alignment Length:	521	Identity:	164/521 - (31%)
Similarity:	262/521 - (50%)	Gaps:	58/521 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VVLLFGAGWIIHLGQA------DRRRKVANLPGPICPPLIGAMQLMLRLNPKTFIKVGREYVLKF 65
            ::||.||.||:....|      |...::...|.|..|........:::.|.::.     :::...
Mouse    21 LLLLGGASWILARILAWIYAFYDNCSRLRCFPQPPKPSWFWGHLALMKNNEESM-----QFITHL 80

  Fly    66 GH----LQRVWI-------------FNRLLIMSGDAELNEQLLSSQEHLVKHPVYKVLGQWLGNG 113
            ||    :...|:             |...|:.:..|...:::          .:|..|..|||:|
Mouse    81 GHDFHDVHLSWVGPVYPILRLVHPNFIAPLLQASAAVAPKEM----------TLYGFLKPWLGDG 135

  Fly   114 LLLSDGKVWHQRRKIITPTFHFSILEQFVEVFDQQSNIC---VQRLAQKANGNTFDVYRSICAAA 175
            ||:|.|..|...|:::||.|||.||:.:|::|::..||.   .|.||.|.. :..|::..|....
Mouse   136 LLMSAGDKWSHHRRLLTPAFHFDILKSYVKIFNKSVNIMHAKWQCLASKGT-SRLDMFEHISLMT 199

  Fly   176 LDIIAETAMGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIR 240
            ||.:.:.........|.::| .|..|:.|.::|:..|....:|.::||:.||....::|:.  ..
Mouse   200 LDSLQKCIFSVDSNCQESDS-KYIAAILELSSLVVKRHRQPFLYLDLLYYLTADGRRFRKA--CD 261

  Fly   241 TMQEFTIKVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVD-GRPLTNDEIREEVD 304
            .:..||..||::||..|..|..:.:...    ...:.:..:|||||:..: |:.|:|::||.|.|
Mouse   262 LVHNFTDAVIKERRSTLNTQGVEFLKAK----AKTKTLDFIDVLLMAEDEHGKGLSNEDIRAEAD 322

  Fly   305 TFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKES 369
            ||||.||||||||||:.|:.|:||||.|.:..:|:.::|....|..:...||.:|.::...||||
Mouse   323 TFMFGGHDTTTSALSWILYNLARHPEYQERCRQEVQELLRDRDSEEIEWDDLAQLPFLTMCIKES 387

  Fly   370 LRMYPPVPIVGRKLQTDFKYTHSVHGDG-VIPAGSEIIIGIFGVHRQPETFPNPDEFIPERH--E 431
            ||::|||.::.|....|.     :..|| .||.|:..:|.|||||..|..:|:|:.:.|.|.  |
Mouse   388 LRLHPPVLLISRCCTQDV-----LLPDGRAIPKGNICVISIFGVHHNPSVWPDPEVYNPFRFDPE 447

  Fly   432 NGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLPMGQRVECIVNIVLRSETGFQ 496
            |..:.:|...||||||.||||||.||..|:|:.||..:..:.:||..:.......::||:|.|..
Mouse   448 NPQKRSPLAFIPFSAGTRNCIGQTFAMSEIKVALALTLLRFRILPDDKEPRRKPELILRAEGGLW 512

  Fly   497 L 497
            |
Mouse   513 L 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	151/454 (33%)
Cyp4f13	NP_570952.1	p450	52..513	CDD:278495	155/488 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845169
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750