Protein Alignment Cyp4d8 and CYP26A1

DIOPT Version :9

• Sequence 1: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_000774.2
• Gene: CYP26A1 / 1592
• HGNCID: 2603
• Length: 497
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 128/500 - (25%)
• Similarity: 213/500 - (42%)
• Gaps: 73/500 - (14%)

  Fly     4 FLLVVLLFGAG---WIIH-LGQADRRRKVANLPGPICPPLIGAMQLMLRLNPKTFIKVGREYVLK 64
            |:|.:|||.|.   |.:: :...||...:...||.:..|..|. .|.:.|..:.|:::.|.   |
Human    14 FVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGE-TLQMVLQRRKFLQMKRR---K 74

  Fly    65 FGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVK-HPVYKVLGQW-------LGNGLL--LSDG 119
            :|.:.:..:|.|..:....|:...::|..:..||. |        |       ||:|.|  |.|.
Human    75 YGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVH--------WPASVRTILGSGCLSNLHDS 131

  Fly   120 KVWH-QRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNTFDVYRSICAAALDIIAETA 183
            .  | ||:|:|...|....||.:|.|..::....:::.......... ||..:......|.....
Human   132 S--HKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLL-VYPEVKRLMFRIAMRIL 193

  Fly   184 MG--TKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFT 246
            :|  .::....:......||..|.|..|      ..|.:::.|:..:..:|.|.....|..|...
Human   194 LGCEPQLAGDGDSEQQLVEAFEEMTRNL------FSLPIDVPFSGLYRGMKARNLIHARIEQNIR 252

  Fly   247 IKVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTNDEIREEVDTFMFEGH 311
            .|:...|             .::...|.|..:.||  :..|...|..|....:::.....:|.||
Human   253 AKICGLR-------------ASEAGQGCKDALQLL--IEHSWERGERLDMQALKQSSTELLFGGH 302

  Fly   312 DTTTSALSFCLHELSRHPEVQAKMLEEIVQ---VLGTDRSRPVSIRDLGELKYMECVIKESLRMY 373
            :||.||.:..:..|..:|.|..|:.||:..   :..:::...:.:..|.:|||:.|||||:||:.
Human   303 ETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLN 367

  Fly   374 PPVPIVGRKLQTDFKYTHSVHGDGV-IPAGSEIIIGIFGVHRQPETFPNPDEFIPERH-----EN 432
            ||||...|.....|:.      :|. ||.|..:|..|...|...|.|.|.:||.|:|.     |:
Human   368 PPVPGGFRVALKTFEL------NGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPED 426

  Fly   433 GSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVR--EYELL 475
            .||   |..|||..|.|:|:|::||::.:|:...::.|  :::||
Human   427 ASR---FSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLL 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	109/433 (25%)
CYP26A1	NP_000774.2	p450	14..492	CDD:299894	127/499 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4598
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.890