Protein Alignment Cyp4d8 and CYP4B1

DIOPT Version :10

• Sequence 1: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 162/518 - (31%)
• Similarity: 265/518 - (51%)
• Gaps: 92/518 - (17%)

  Fly    39 LIGAMQLM-LRLNPKTFIKVGREYVLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHP- 101
            ::|.::|: |.|..:|..|.    :.||......|:|...|.:.....|::.:..:.:....||
Human    23 VLGFLKLIHLLLRRQTLAKA----MDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPL 83

  Fly   102 ------------------------------VYKVLGQWLGNGLLLSDGKVWHQRRKIITPTFHFS 136
                                          ||....||:|.|||:.:|..|.|.||::||.||:.
Human    84 WFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYD 148

  Fly   137 ILEQFVEVFDQQSNICVQRLAQKA-NGNTFDVYRSICAAALDII-------AETAMGTKIYAQAN 193
            :|:.:|.||.:.:.|.:.:..:|| .|.:||::..:...||:.:       .:|.:|     .:.
Human   149 VLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLG-----HSR 208

  Fly   194 ESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTIKVIEKRRQALE 258
            :|:.|. ||::.|.|:..|.:|.....:.::.|| ||.: |..:..:...:.|.:||.:|:.||:
Human   209 DSSYYL-AVSDLTLLMQQRLVSFQYHNDFIYWLT-PHGR-RFLRACQVAHDHTDQVIRERKAALQ 270

  Fly   259 DQQSKLMDTADEDVGSKRRMALLDVLL-MSTVDGRPLTNDEIREEVDTFMFEGHDTTTSALSFCL 322
            |::.:      :.:.::|.:..||:|| ....|...|::.::|.|||||||||||||||.:|:.|
Human   271 DEKVR------KKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFL 329

  Fly   323 HELSRHPEVQAKMLEEIVQVLGT------DRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVGR 381
            :.::.:||.|.:..||:.::||.      |        |||::.|:...||||.|:|||||.|.|
Human   330 YCMALYPEHQHRCREEVREILGDQDFFQWD--------DLGKMTYLTMCIKESFRLYPPVPQVYR 386

  Fly   382 KLQTDFKYTHSVHGDG-VIPAGSEIIIGIFGVHRQPETFPNPDEFIPERH--ENGSRVAPFKMIP 443
            :|.....:.     || .:||||.|.:.|:.:||....:|:|:.|...|.  ||.|:..||..:|
Human   387 QLSKPVTFV-----DGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMP 446

  Fly   444 FSAGPRNCIGQKFAQLEMKMMLAKIVREYEL------LPMGQRVECIVNIVLRSETGFQLGMR 500
            |||||||||||:||..|||::.|..:..:|.      ||:.     :..:||||:.||.|.::
Human   447 FSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIK-----MPQLVLRSKNGFHLHLK 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	153/485 (32%)
CYP4B1	NP_001093242.1	CYP4B-like	67..502	CDD:410771	150/466 (32%)