Protein Alignment Cyp4d8 and CYP4A11

DIOPT Version :10

• Sequence 1: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Alignment Length: 506
• Identity: 154/506 - (30%)
• Similarity: 261/506 - (51%)
• Gaps: 71/506 - (14%)

  Fly    39 LIGAMQLMLRLNPKTFIKVGREYVLK-------------FGHLQRV------------------- 71
            ||.|:||.|.          |:::||             |||:|.:
Human    31 LIKAVQLYLH----------RQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRIQKWVETFPSA 85

  Fly    72 ---WIF-NRLLIMSGDAELNEQLLSSQEHLVKHPVYKVLGQWLGNGLLLSDGKVWHQRRKIITPT 132
               |:: .::.:...|.:..:.:|...:. ..|..|:.|..|:|.||||.:|:.|.|.|:::||.
Human    86 CPHWLWGGKVRVQLYDPDYMKVILGRSDP-KSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPA 149

  Fly   133 FHFSILEQFVEVFDQQSNICVQRLAQ-KANGNTFDVYRSICAAALDIIAETAMGTKIYAQAN-ES 195
            ||:.||:.:|.:......:.:.:..: ....:..:|::.:....||.|.:.|...:...|.: .|
Human   150 FHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNS 214

  Fly   196 TPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKW--RQTQLIRTMQEFTIKVIEKRRQALE 258
            ..|.:|:::...|:..|..:.:.|.:.:::||... :|  |..||   ..:.|.:||:.|:..|:
Human   215 QSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAG-RWTHRACQL---AHQHTDQVIQLRKAQLQ 275

  Fly   259 DQQSKLMDTADEDVGSKRRMALLDVLLMSTVD-GRPLTNDEIREEVDTFMFEGHDTTTSALSFCL 322
             ::.:|     |.:..||.:..||:||::.:: |..|::.::|.|||||||||||||.|.:|:.|
Human   276 -KEGEL-----EKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWIL 334

  Fly   323 HELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVGRKLQTDF 387
            :.|:.||:.|.:..|||..:||...|  ::...|.::.|....|||:||:|||||.:||:|.|..
Human   335 YALATHPKHQERCREEIHSLLGDGAS--ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPV 397

  Fly   388 KYTHSVHGDG-VIPAGSEIIIGIFGVHRQPETFPNPDEFIPERHENGSRVAPFKMIPFSAGPRNC 451
            .:.     || .:|.|..:::.|:|:|..|:.:|||:.|.|.|...||.......:|||.|.|||
Human   398 TFP-----DGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNC 457

  Fly   452 IGQKFAQLEMKMMLAKIVREYELLPMGQRVEC-IVNIVLRSETGFQLGMRK 501
            ||::||..|:|:..|..:..:||||...|:.. |..:||:|:.|..|.:|:
Human   458 IGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRLRR 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	142/460 (31%)
CYP4A11	NP_000769.2	CYP4B-like	74..505	CDD:410771	139/448 (31%)