Protein Alignment Cyp4d8 and CYP3A5

DIOPT Version :10

• Sequence 1: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 131/501 - (26%)
• Similarity: 240/501 - (47%)
• Gaps: 72/501 - (14%)

  Fly     1 MLLFLLVVLLFGAGWIIHLGQADRRRKVANLPGPICPPLIGAM----QLMLRLNPKTFIKVGREY 61
            :||.:.:|||:..|...| |...|    ..:|||...||:|.:    |.:.:.:.:.:.|.|:.:
Human    13 LLLAVSLVLLYLYGTRTH-GLFKR----LGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMW 72

  Fly    62 VLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHPVYKV------LGQ--WLGNGLLLSD 118
            ....|.|..:.|.:..:|              :..|||. .|.|      ||.  ::.:.:.|::
Human    73 GTYEGQLPVLAITDPDVI--------------RTVLVKE-CYSVFTNRRSLGPVGFMKSAISLAE 122

  Fly   119 GKVWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKA-NGNTFDVYRSICAAALDIIAET 182
            .:.|.:.|.:::|||....|::...:..|..::.|:.|.::| .|....:.....|.::|:|..|
Human   123 DEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGT 187

  Fly   183 AMGTKIYAQANESTPYAEAVNECTALLSWRFMS-VYLQVELLFTLTHPHLKWRQTQLIRTMQEFT 246
            :.|..|.:..|...|:.|:..:   .|.:.|:. ::|.: :||....|..:.....|   ..:.|
Human   188 SFGVNIDSLNNPQDPFVESTKK---FLKFGFLDPLFLSI-ILFPFLTPVFEALNVSL---FPKDT 245

  Fly   247 IKVIEK-----RRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMS-----TVDGRPLTNDEIRE 301
            |..:.|     ::..|.|:|             |.|:..|.:::.|     |...:.|::.|:..
Human   246 INFLSKSVNRMKKSRLNDKQ-------------KHRLDFLQLMIDSQNSKETESHKALSDLELAA 297

  Fly   302 EVDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVI 366
            :...|:|.|::||:|.|||.|:||:.||:||.|:.:||..||  ....|.:...:.:::|::.|:
Human   298 QSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL--PNKAPPTYDAVVQMEYLDMVV 360

  Fly   367 KESLRMYPPVPIVGRKLQTDFKYTHSVHGDGVIPAGSEIIIGIFGVHRQPETFPNPDEFIPER-H 430
            .|:||::|    |..:|:...|....::| ..||.||.::|..:.:|..|:.:..|:||.||| .
Human   361 NETLRLFP----VAIRLERTCKKDVEING-VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS 420

  Fly   431 ENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLP 476
            :....:.|:...||..|||||||.:||.:.||:.|.::::.:...|
Human   421 KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKP 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	113/432 (26%)
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	115/442 (26%)